Relationship between depression and blood cytokine levels in lung cancer patients

Abstract

> Objective: To study the correlation between depression and blood cytokine levels in lung cancer patients. Methods: 92 patients with advanced lung cancer were evaluated for depression using the scoring index of depression self-rating scale. Lack of depression (n=24), mild depression (n=45), and moderate depression (n=23) were found in the cohort. Meanwhile, 40 healthy subjects were selected as the control group. The levels of IL-10, IL-6, IL-8, and TNF-α in each group were detected by sandwich enzyme-linked immunosorbent assays, and their correlation with the degree of depression was analyzed. Results: The levels of IL-10, IL-6, IL-8, and TNF-α were all higher than those in the control group (P<0.05). Moreover, the depression statuses of patients with lung cancer were positively correlated with IL-10, IL-6, and TNF-α levels (r = 0.705, 0.301, and 0.446, P<0.01); however, the level of IL-8 was not relevant (r=0.136, p>0.05). Conclusion: Serum levels of IL-10, IL-6, and TNF-α are associated with depression scoring in patients with lung cancer. <

Role of Interleukin-6 in Depressive Disorder

“…In 2001, Musselman et al first reported that cancer patients with depression had significantly higher plasma IL-6 levels than healthy control subjects and cancer patients without depression [60]. Similar findings were demonstrated that the depression state was positively correlated with IL-6 levels in patients with cancer [61], lung cancer [62], colorectal cancer [63], pancreatic cancer [64], breast cancer [65,66], metastatic cancer [67], advanced cancer [68] and ovarian cancer [69]. One study investigated IL-6 level changes in six months following primary treatment in ovarian cancer patients [70].…”

Pulmonary hypertension: Pathophysiology beyond the lung

“…Recent studies have correlated depression, a very common symptom in PH patients, to increased levels of circulating pro-inflammatory cytokines and microglial activation (48,62,92,128). Pro-inflammatory cytokines positively correlated with depression score index in a study of 92 patients diagnosed with lung cancer (62).…”

Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

“…COVID-19 is usually accompanied by an elevation of numerous bioactive factors such as IL-1β, TNF-α, IL-2, IL-7, IL-8, IL-9, IL-17 G-CSF, interferon (IFN)-γ, XXC-10, CCL-2 CCL-3, CCL-4, and especially IL-6, which is produced predominantly by macrophages [110,111]. The severe and frequently fatal character of the disease is characterised by a high level of IL-6 and CRP in the blood or plasma of the patients [112][113][114][115]. IL-6, in collaboration with other factors, influences the endothelial cells of lung capillaries, increasing their permeability for serum proteins and improving the transmigration of inflammatory cells [116].…”