Relationship Between Cystic Disease of the Breast and Carcinoma

Campbell, O.

doi:10.1001/archsurg.1934.01170180003001

Cited by 25 publications

(2 citation statements)

References 48 publications

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“…Although several epidemiological studies revealed increased relative risk of subsequent BC in women who have had previously GCBD [5,14, [32][33][34], other cohort studies have failed to find any increased relative risk [35][36][37][38][39][40][41][42][43][44][45][46], concluding that GCBD cannot be considered a precancerous lesion per se (Table 3 and 4). Different risk profiles were also found in gross cyst subtypes [22,62], showing that Type I apocrine gross cysts are frequently associated with an increased risk of BC [6,24,34,59,63], even though several controversial/conflictual results are reported [29,45,58,60,64,65].…”

Section: Relationship Between Gcbd and Bcmentioning

confidence: 99%

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Mannello

Tonti

Papa

2005

Breast Cancer Res Treat

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For more than one and a half century the cystic disease of the breast has been recognized as the most frequent female benign breast lesion. Although some conundrums and controversies exist about the relation between gross cysts and breast cancer, recent evidence suggests that the multidisciplinary study of gross cystic breast disease (GCBD) may be a powerful tool for predicting the natural history of the multifaceted gross cyst pathology. A lot of papers have been published on breast cyst fluids (BCF) concerning biochemical, hormonal and morphological aspects, demonstrating that the intracystic fluid contains a wide variety of components (such as ions, lipids, proteins, enzymes, growth factors and antigens) and suggesting that their profile provides additional knowledge on both physiopathology and etiologic pathways of human gross cystic breast disease. The aim of this overview is the critical evaluation of all data accumulated in the last thirty years, in order to highlight the utility of biochemical and epidemiological studies to identify gross cysts, if any, at higher breast cancer risk.

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Section: Relationship Between Gcbd and Bcmentioning

confidence: 99%

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Mannello

Tonti

Papa

2005

Breast Cancer Res Treat

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“…But to take the most important observations, Bloodgood (1931), who throughout the early part of the century wrote many papers on the subject, reported a follow-up for periods of up to 30 years of more than 100 patients from whom bluedomed cysts had been removed, and found nonehad developed cancer. Campbell (1934) refers to 233 cases of "chronic mastitis" treated by local excision of areas of breast tissue and followed up for from 2 to 14 years. In one patient only did carcinoma of the breast develop.…”

Section: Discussionmentioning

confidence: 99%