Relationship between CYP17 gene polymorphisms and risk of prostate cancer

Song, Jia; Zh, Tao; Xy, Liu; Gong, Shi-Cai; Gan, Liangbing

doi:10.4238/gmr.15017866

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…Our results were in agreement with Konstantinos et al, who suggested that the C allele of (T/C) polymorphism may provide additional promoter activity with an increased rate of CYP17 mRNA transcription [22]. The polymorphism is thought to induce CYP17 gene expression resulting in higher levels of androgens and, consequently, in a higher risk of the development and progression of prostate disease [23], [24].…”

Section: Discussionsupporting

confidence: 92%

Common variation of the CYP17 gene in Iraqi women with endometriosis disease

2017

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Common variants among genes coding for enzymes in sex steroid biosynthetic pathways may influence the risk of endometriosis in Iraqi women patients in the last years. Cytochrome P450c17a1 (CYP17), a gene that codes for a key enzyme (cytochrome P450c17a1) in a rate-limiting step of estrogen biosynthesis has attracted considerable attention as an important gene for endometriosis. To evaluate the relationship between common genetic variations in CYP17 and endometriosis risk and determine the main effects of those variations on the gene expression. A women-based case control study of Iraqi women aged range (23–46), the associations between selected single-nucleotide polymorphisms (SNPs) in the CYP17 gene and endometriosis diagnosis in fifty women and thirty disease-free controls were evaluated. The study found a significant association (P ≤ 0.01)between endometriosis and selected SNPs of CYP17 gene, with the homozygous genotype conferring decreased risk. A highly significant difference (P ≤ 0.01) in CYP17 gene expression from women with versus without endometriosis and increased by 1.56-fold in women with endometriosis. These findings suggest that variation in or around CYP17 may be associated with endometriosis development in the Iraqi women.

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Section: Discussionsupporting

confidence: 92%

Common variation of the CYP17 gene in Iraqi women with endometriosis disease

2017

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“…Furthermore, a study engaged by Konstantinos et al, confirms our results by suggesting that the C allele of rs743572 polymorphism might influence promoter activity with an increased amount of CYP17A1 mRNA transcription (27) . The rs743572 polymorphism increases the levels of androgen due to the induction of CYP1A1 gene expression that ultimately resulted in the development and progression of prostate disorders (28) .…”

Section: Discussionmentioning

confidence: 99%

Association between CYP17A1, CYP19A1, and HSD17B1 Gene Polymorphisms in Hormone Synthesis pathway with Ovarian Cancer Risk

Francis

Paul

et al. 2020

Preprint

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Objective: To investigate the polymorphisms of genes in the steroidogenesis pathway to understand the etiological mechanisms to OC risk in the South Indian population Design: Case-Control Study Setting and Sample: Ovarian cancer cases (200) and healthy individuals (200) from the South Indian population. Methods: All the cases and controls were genotyped for SNPs by using allelic discrimination assay. Main outcome measures: Genetic distribution of SNPs of Steroidogenesis pathway genes in the South Indian population. Results: The observed results for rs743752, the homozygous CC genotype revealed significant association (OR; 1.68; 95%CI, 1.25-2.26; p =<0.05) and the dominant model, recessive model and additive model showed a significant association with an OR of 1.62; 95%CI, 1.09-2.42; p = 0.015, OR of 0.29, 95%CI, 0.14-0.60; p = <0.001 and OR of 1.68, 95%CI, 1.25-2.26); p = <0.001 respectively in cases and controls for OC risk. In rs10046, the heterozygous CT genotype (OR; 1.61; 95%CI 1.06-2.43; p = 0.023), the dominant (OR; 1.65; 95%CI, 1.11-2.45; p = 0.012) and the additive (OR; 1.46; 95%CI, 1.07-1.98; p = 0.015) models were found to be statistically significant. There was no significant association between rs605059 genotypes with ovarian cancer risk. Conclusions: To conclude, results indicated that the polymorphisms of CYP17A1 (rs743572) and CYP19A1 (rs10046) genes are associated with increased risk of ovarian cancer risk in South Indian population.

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“…[ 23 ] It has been considered that rs743572 SNP is related to the expression of CYP17; T allele might induce the upregulation of CYP17 in patients with prostate cancer. [ 25 ] However, the effects of rs743572 on endometriosis were not clear.…”

Section: Discussionmentioning

confidence: 99%

CYP17A1 rs743572 polymorphism might contribute to endometriosis susceptibility

Cong

Gao

2018

Medicine

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This case–control study was aimed to evaluate the influence of cytochrome P450 family 17 subfamily A member 1 (CYP17A1) gene rs743572 polymorphism for the susceptibility to endometriosis.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype rs743572 polymorphism in 143 endometriosis patients and 148 healthy controls. Hardy–Weinberg equilibrium (HWE) test was utilized to detect the representativeness of the study subjects. Association strength was presented by odds ratios (ORs) with corresponding 95% confidence intervals (CIs).Genotype distribution of rs743572 polymorphism was conformed to HWE test both in case and control groups, revealing the good representativeness of our study subjects. Significantly positive association was discovered between rs743572 TT genotype and endometriosis susceptibility (P = .042, OR = 1.952, 95% CI = 1.020–3.736). Rs743572 T allele was more frequently discovered in cases than that in controls, revealing the enhanced susceptibility to endometriosis (P = .041, OR = 1.407, 95% CI = 1.014–1.951). Confounding factors (age and body mass index) were utilized to adjust the results, and then we found that the association strength had no significant changes (TT vs CC, P = .039, OR = 1.961, 95% CI = 1.023–3.742; T vs C, P = .038, OR = 1.413, 95% CI = 1.016–1.957). But we failed to find any obvious association of rs743572 genotypes with endometriosis stages and characteristics.T allele of rs743572 polymorphism might act as a risk factor for endometriosis, although it had no effects on the disease stages and basic features.

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Relationship between CYP17 gene polymorphisms and risk of prostate cancer

Cited by 5 publications

References 18 publications

Common variation of the CYP17 gene in Iraqi women with endometriosis disease

Common variation of the CYP17 gene in Iraqi women with endometriosis disease

Association between CYP17A1, CYP19A1, and HSD17B1 Gene Polymorphisms in Hormone Synthesis pathway with Ovarian Cancer Risk

CYP17A1 rs743572 polymorphism might contribute to endometriosis susceptibility

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