Relationship between COVID‐19 and movement disorders: A narrative review

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 2019-nCoV) emerged in December 2019 and spread into a worldwide pandemic. More than 260 million people worldwide have been verifiably infected with Sars-CoV-2 (as of December 2021), with more than 5.2 million deaths. The number of human coronavirus disease 2019 (COVID-19) cases continues to rise as countries roll out their vaccine programs. There is a broad range of clinical presentations of COVID-19, including neurological manifestations [1]. It is estimated that 10%-30% of COVID-19 patients develop neurological symptoms in the acute phase, which may be the presenting sign. Neurological manifestations of COVID-19 include cerebrovascular disorders, including ischemic stroke and macro/microhemorrhages, encephalopathies and (meningo-)encephalitis, para-/postinfectious immune-mediated complications such as Guillain-Barré syndrome, movement disorders, and neuropsychiatric complications [2-4]. In parallel to the

Parkinson’s disease related mortality: Long-term trends and impact of COVID-19 pandemic waves

“…People with PD have also experienced indirect consequences of the pandemic. The introduction of lockdown restrictions and social disruption contributed to compromise the overall wellbeing of subjects with PD, including negative effects on their motor status and mental health compared to pre-pandemic conditions [ 9 ]. Furthermore, patients may have experienced barriers in the access to care (delays in routine clinical visits and elective surgical procedures).…”

Movement Disorders Induced by SARS-CoV-2 Infection: Protocol for a Scoping Review

“…Three narrative reviews were excluded from the ten articles assessed in full text as the authors did not perform a systematic literature search. Seven reviews used a systematic search [10,11,[17][18][19][20][21]. However, two reviews searched only one database [11,19], limiting the number of possible published cases.…”

“…In addition, another review searched PubMed and Medline, which is a subset of PubMed [17]. A narrative review searched PubMed and a preprint server [10]. The date of three published reviews is relatively old for the rapidly evolving research on COVID-19 [11,17,20], and several authors did not specify the date of their searches [18,21].…”

“…Furthermore, up to one-third of the patients with SARS-CoV-2 infection develop neurologic complications, including movement disorders [3]. The most frequent movement disorders were reported to be myoclonus and ataxia [10,11], but patients may also present with chorea, tremor, or dystonia [11]. Interestingly, previous reviews reported a predominance of hyperkinetic movement disorders, while hypokinetic disorders were rare [12].…”

SARS-CoV-2 vaccination, Parkinson’s disease, and other movement disorders: case series and short literature review

“…The Movement Disorder Society (MDS) highly recommended vaccination for PD patients, considering their higher risk for worse clinical outcome, especially reported on patients in advanced therapy, which present an additional risk of vulnerability [ 2 , 3 ]. Noteworthy, new onset of movement disorders may occur in the context of Coronavirus Disease 2019 (COVID-19) [ 4 ].…”