Parkinson’s disease related mortality: Long-term trends and impact of COVID-19 pandemic waves

Fedeli, Ugo; Casotto, Veronica; Amidei, Claudio Barbiellini; Saia, Mario; Netti, Silvia Tiozzo; Basso, Cristina; Schievano, Elena

doi:10.1016/j.parkreldis.2022.04.011

Cited by 13 publications

(13 citation statements)

References 12 publications

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Section: Covid-19 and Pdmentioning

confidence: 99%

“…A study in Italy investigated the long-term trends and impact of COVID-19 pandemic waves on PD-related mortality [ 11 ]. In that study, 13,746 PD-related deaths (2.3% of all deaths) were identified during 2008–2020, with proportional mortality increased from 1.9% (2008) to 2.8% (2020) [ 11 ]. The PD-related mortality rate when considering PD as one among multiple causes reported in death certificates during 2020 was 28%, showing two peaks corresponding to the first (March to May, 28%) and second (October to December, 59%) pandemic waves that occurred in Italy [ 11 ].…”

Section: Covid-19 and Pdmentioning

confidence: 99%

“…In that study, 13,746 PD-related deaths (2.3% of all deaths) were identified during 2008–2020, with proportional mortality increased from 1.9% (2008) to 2.8% (2020) [ 11 ]. The PD-related mortality rate when considering PD as one among multiple causes reported in death certificates during 2020 was 28%, showing two peaks corresponding to the first (March to May, 28%) and second (October to December, 59%) pandemic waves that occurred in Italy [ 11 ]. Generally, PD-related mortality rates were steeply increased during the COVID-19 pandemic [ 11 ].…”

Section: Covid-19 and Pdmentioning

confidence: 99%

“…The PD-related mortality rate when considering PD as one among multiple causes reported in death certificates during 2020 was 28%, showing two peaks corresponding to the first (March to May, 28%) and second (October to December, 59%) pandemic waves that occurred in Italy [ 11 ]. Generally, PD-related mortality rates were steeply increased during the COVID-19 pandemic [ 11 ]. A retrospective review of 70 PD inpatients in New York found that PD patients with COVID-19 infection had a higher mortality rate compared to those not infected (35.8% vs 5.9%, P = 0.028) [ 24 ].…”

Section: Covid-19 and Pdmentioning

confidence: 99%

“…COVID-19 could lead to accelerated aging in the brain [ 9 , 10 ]. Furthermore, patients with PD and AD have been reported with higher risks of COVID-19 infection, hospitalization, and mortality, indicating a close link between COVID-19 and neurodegenerative diseases [ 11 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Links between COVID-19 and Parkinson’s disease/Alzheimer’s disease: reciprocal impacts, medical care strategies and underlying mechanisms

Huang

Zhang

Tan

et al. 2023

Transl Neurodegener

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The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with neurodegenerative diseases and the specific neurological manifestations of COVID-19 have aroused great interest. However, there are still many issues of concern to be clarified. Therefore, we review the current literature on the complex relationship between COVID-19 and neurodegenerative diseases with an emphasis on Parkinson’s disease (PD) and Alzheimer’s disease (AD). We summarize the impact of COVID-19 infection on symptom severity, disease progression, and mortality rate of PD and AD, and discuss whether COVID-19 infection could trigger PD and AD. In addition, the susceptibility to and the prognosis of COVID-19 in PD patients and AD patients are also included. In order to achieve better management of PD and AD patients, modifications of care strategies, specific drug therapies, and vaccines during the pandemic are also listed. At last, mechanisms underlying the link of COVID-19 with PD and AD are reviewed.

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Section: Covid-19 and Pdmentioning

confidence: 99%