Relationship between corticosteroid dose and declines in physical function among allogeneic hematopoietic stem cell transplantation patients

Abstract

This study showed the relationship between corticosteroid dose and declines in physical function and also showed other clinical factors affecting loss of physical function among allo-HSCT patients. Our results indicate that the effectiveness of rehabilitation may be influenced by corticosteroid treatment.

Effect of exercise therapy on muscle mass and physical functioning in patients undergoing allogeneic hematopoietic stem cell transplantation

“…In general, steroid-induced muscle weakness tends to affect lower limb muscles more than upper limb muscles [29]. However, in allo-HSCT patients, steroid dose has been more strongly associated with declines in handgrip strength than declines in knee extensor strength [30]. Our result was similar to this report.…”

Relationship of physical activity with physical function and health-related quality of life in patients having undergone allogeneic haematopoietic stem-cell transplantation

“…However, these studies did not show the details regarding physical activity and did not investigate the intensity levels of physical activity; they only examined steps and activity times. In our previous research, we reported an overall decrease in physical function after HSCT, including decreases in muscle strength and exercise capacity (Morishita, Kaida, Yamauchi, Sota, et al., , ) and quality of life (QOL) (Morishita, Kaida, Yamauchi, Wakasugi, et al., ). Other studies have also reported decreases in physical function and QOL after HSCT, compared to pre‐transplantation levels, in patients having undergone allo‐HSCT (Takekiyo et al., ; Wiskemann et al., ).…”

Interdisciplinary care programme to improve self-management for cancer patients undergoing stem cell transplantation: a prospective non-randomised intervention study

“…Despite better therapy options and long‐term survival rates (Copelan ) symptoms and complications like muscle weakness, oral mucositis (OM) and malnutrition may still occur simultaneously, interact and reduce patients' quality of life (Morishita et al . ). However, patients' physical condition may already be significantly impaired before treatment.…”

“…Studies show significant reductions of muscle strength (Morishita et al . ), handgrip and knee extension in both men and women after HSCT (Morishita et al . ).…”