Relationship of physical activity with physical function and health-related quality of life in patients having undergone allogeneic haematopoietic stem-cell transplantation

Morishita, Shinichiro; Kaida, Katsuji; Yamauchi, Shinya; Wakasugi, Tatsushi; Ikegame, Kazuhiro; Ogawa, Hiroyasu; Domen, Kazuhisa

doi:10.1111/ecc.12669

Cited by 45 publications

(25 citation statements)

References 45 publications

(56 reference statements)

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“…Findings showed that liver transplant recipients had limited knowledge, if any, about post-LT self-care, particularly in areas such as nutrition, physical activity, medications, and symptom management. In line with this finding, previous studies showed lack of self-care knowledge about medications among liver transplant recipients (21), about physical activity among bone marrow transplant recipients (22), and about nutrition and transplant rejection symptoms among kidney transplant recipients (23). Moreover, we found that recipients gradually lost their interest in selfcare after LT due to experiencing improvements in their conditions.…”

Section: Discussionsupporting

confidence: 89%

Patients’ Experiences of Life Challenges After Liver Transplantation: A Qualitative Study

Taher

Toossi

Jafarian

et al. 2021

Journal of Patient Experience

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Patients experience a new life with different challenges after liver transplantation (LT). Identifying these challenges can facilitate the improvement of their quality of life. This study aimed to explore patients’ experiences of post-LT life challenges. This qualitative study was performed in 2019 through the content analysis approach. Participants were liver transplant recipients purposively recruited from a LT clinic. Semistructured interviews were conducted for data collection. Data were analyzed through Graneheim and Lundman’s conventional content analysis approach. Meaning units were identified and coded, and the codes were grouped into subcategories and categories according to their similarities. In total, 18 transplant recipients were interviewed. Their age mean was 51 years and their transplant age ranged from 4 months to 12 years. Their post-LT life challenges were categorized into 4 main categories, that is, self-care deficit, the need for seeking information, fears and concerns, and hope–despair duality. Nurses and members of LT team are recommended to assess transplant recipients’ life challenges and develop comprehensive plans for managing their challenges and problems and improving their quality of life.

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Section: Discussionsupporting

confidence: 89%

Patients’ Experiences of Life Challenges After Liver Transplantation: A Qualitative Study

Taher

Toossi

Jafarian

et al. 2021

Journal of Patient Experience

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“…The effects of AHCT on physical performance as measured by the 6MWT are not well-established. Whereas a significant reduction in 6MWT was reported acutely after allogeneic HCT [14,15], no change was reported after AHCT in a different report [16]. In other disease populations, change in 6MWT is clinically relevant.…”

Section: Discussionmentioning

confidence: 98%

Assessing Cachexia Acutely after Autologous Stem Cell Transplant

Anderson

Yin

Burciaga

et al. 2019

Cancers

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Autologous hematopoietic stem cell transplantation (AHCT) is an accepted strategy for various hematologic malignancies that can lead to functional impairment, fatigue, muscle wasting, and reduced quality of life (QOL). In cancer cachexia, these symptoms are associated with inflammation, hypermetabolism, and decreased anabolic hormones. The relative significance of these factors soon after AHCT setting is unclear. The purpose of this study was to characterize the acute effects of AHCT on physical function, body composition, QOL, energy expenditure, cytokines, and testosterone. Outcomes were assessed before (PRE) and 30 ± 10 days after (FU) AHCT in patients with multiple myeloma (n = 15) and non-Hodgkin lymphoma (n = 6). Six-minute walk test (6MWT; p = 0.014), lean mass (p = 0.002), and fat mass (p = 0.02) decreased; nausea and fatigue increased at FU (both p = 0.039). Recent weight change and steroid exposure were predictors of reduced aerobic capacity (p < 0.001). There were no significant changes in interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF), energy expenditure, or bioavailable testosterone. Alterations in cytokines, energy expenditure, and testosterone were not associated with functional impairment acutely following AHCT. Recent history of weight loss and steroid exposure were predictors of worse physical function after AHCT, suggesting that targeting nutritional status and myopathy may be viable strategies to mitigate these effects.

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“…Advancement in allo-HSCT conditioning regimens, treatments for opportunistic infectious complications, and management of graft versus host disease (GVHD) have improved the five-year net survival rate for blood-related cancers [ 1 ]. Unfortunately, allo-HSCT patients experience significant reductions in physical capacity as a result of pre-transplant conditioning regimens [ 2 , 3 , 4 , 5 ] and post-transplant comorbidities [ 6 ] that are associated with reduced psychological wellbeing [ 7 , 8 ], survival [ 9 , 10 ], and short- and long-term health-related quality of life (HRQOL) [ 11 , 12 ]. Compounding this, physical capacity is further impacted by prolonged physical inactivity during hospital stays [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial

Mina

Dolan

Lipton

et al. 2020

JCM

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People with cancer who undergo allogeneic hematological stem cell transplant (allo-HSCT) experience significant deconditioning that can compromise quality of life. Exercise has shown to be beneficial before or after allo-HSCT; however, little is known about exercise therapy delivered across the continuum of care. We conducted a feasibility randomized controlled trial of exercise delivered prior to admission, during the inpatient stay, and after discharge versus control in people with planned allo-HSCT. Feasibility was assessed via recruitment and retention rates, the incidence of adverse events, and adherence to the exercise prescription. Estimates of efficacy were measured at baseline, one week prior to hospital admission, and 100 days and one year after transplant. The recruitment and retention rates were 20% and 33%, respectively. One serious adverse event occurred during the baseline six-minute walk test that precluded participation in the study and no adverse events were associated with the intervention. From baseline to pre-transplant, the intervention group improved six-minute walk test distances by 45 m (95% CI: −18.0 to 108.7)—a finding that warrants further investigation with an adequately powered trial. Our study contributes important feasibility considerations and pilot data for future exercise intervention research in allo-HSCT recipients.

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Relationship of physical activity with physical function and health-related quality of life in patients having undergone allogeneic haematopoietic stem-cell transplantation

Cited by 45 publications

References 45 publications

Patients’ Experiences of Life Challenges After Liver Transplantation: A Qualitative Study

Patients’ Experiences of Life Challenges After Liver Transplantation: A Qualitative Study

Assessing Cachexia Acutely after Autologous Stem Cell Transplant

Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial

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