Relationship between coronary risk factor and arteriographic feature of coronary atherosclerosis.

Hiyamuta, Kohji; Toshima, Hironori; Koga, Yoshinori; Nakayama, Hiroshi; Yamaga, Akihiko; Shiraishi, Akihiko; Maruyama, Hidekatsu; Hidaka, Yoshio; Ueno, Takayoshi; Yoshiga, Osamu; Shibata, Junichi; Ikeda, Hisao; Tashiro, Hiromi; Yoh, Masayoshi; Harada, K

doi:10.1253/jcj.54.442

Cited by 16 publications

(6 citation statements)

References 7 publications

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“…Coronary angiography (CAG) is a useful tool for diagnosing and evaluating the severity of coronary artery disease. A strong correlation between coronary risk factors and CAG findings has been established [20][21][22][23][24][25][26] . Although occupation categories can be surrogate measures for coronary risk factors, the relationship between taxi driving and severity of CHD, as determined angiographically, has not been investigated.…”

Section: Introductionmentioning

confidence: 90%

Characteristics of Coronary Heart Disease in Japanese Taxi Drivers as Determined by Coronary Angiographic Analyses.

et al. 2000

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Several epidemiological studies have shown that the prevalence of ischemic heart disease is higher in occupational drivers than in people with other occupations. Although occupation categories can be surrogate measures for coronary risk factors, the relationships between taxi driving and severity of coronary heart disease (CHD) has not been investigated. Even more important, the contribution of risk factors to the severity of CHD in taxi drivers remains unclear. Our study tested the hypothesis that taxi driving could be associated with the severity of CHD. We also examined the relation between this occupation and risk factors and social lifestyle. We analyzed the coronary angiograms of 57 consecutive male taxi driver patients and compared them with those of 215 ageadjusted male non-taxi-driver patients. The number of diseased vessels and risk factors were compared between two groups. The prevalence of myocardial infarction and multi-vessel disease was higher in the taxi-driver patients than in the non-taxi-driver patients. The taxi-driver patients had higher prevalence of body mass index (BMI), diabetes, and smoking, higher levels of low-density lipoprotein cholesterol (LDL-C), and lower levels of apolipoprotein AI (ApoAI). Multiple logistic regression analysis showed that multi-vessel disease was associated with BMI and diabetes mellitus in taxi-driver patients. The taxi-driver patients were characterized by more extensive coronary atherosclerosis associated with higher prevalence of diabetes mellitus and obesity. These characteristics may be explained by in part their working environment.

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Section: Introductionmentioning

confidence: 90%

Characteristics of Coronary Heart Disease in Japanese Taxi Drivers as Determined by Coronary Angiographic Analyses.

et al. 2000

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“…Retrospective, observational studies and prospective, longitudinal cohort studies have reported positive associations between elevated serum uric acid (SUA) levels and heart disease [2,3,4,5,6,7,8,9,10,11,12] The significance of these associations, though, has been questioned because of observed relationships between elevated SUA and traditional cardiovascular risk factors, such as glucose intolerance, diabetes and hyperlipidemia, as well as diuretic use [13,14,15,16,17]…”

Section: Introductionmentioning

confidence: 99%

Serum Uric Acid Independently Predicts Mortality in Patients with Significant, Angiographically Defined Coronary Disease

et al. 2005

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Background: Uric acid is a nontraditional risk factor implicated in the development of coronary artery disease (CAD). This study prospectively evaluated the predictive value of serum uric acid (SUA) levels for mortality after angiographic diagnosis of CAD. Methods: Blood samples were collected from 1,595 consecutive, consenting patients with significant, angiographically defined CAD (stenosis 70%). Baseline and procedural variables were recorded and levels of SUA were measured. Patients were followed to death or to the time of contact (mean 2.6 years, range 1.8–5.0 years). Results: Patients averaged 65 ± 11 years of age, 78% were male and 170 subjects died during the follow-up period. In univariate analysis of prospectively defined quintiles, SUA predicted all-cause mortality (fifth quintile vs. first four quintiles: hazard ratio 1.9, p < 0.001). In multivariable Cox regression controlling for 20 covariables, independent predictive value for mortality was retained by SUA (hazard ratio 1.5, confidence interval 1.02–2.1, p = 0.04). In subgroup analysis based on diuretic use status, SUA independently predicted mortality among patients not using diuretics, while SUA was not a significant predictor of mortality among those who used diuretics. Conclusions: In patients with significant, angiographically defined CAD, SUA predicted mortality independent of traditional risk factors. This suggests that elevated SUA may be a risk factor for mortality in patients with significant cardiovascular disease and may be a stronger secondary than primary risk factor in CAD.

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“…Although numerous studies have investigated the association between serum uric acid and CAD, few have examined the relationship between uric acid and the extent of the disease assessed by coronary angiography. Hiyamuta et al (1990) failed to demonstrate any relationship between serum uric acid and the extent of CAD, but the majority of their patients were males (87%) and genderspecific comparisons were not performed. Kotake et al (1992) reported that the concentration of serum uric acid in 40 women correlated with the number of arteries exhibiting ≥ 50% stenosis, whereas no significant changes were seen in men.…”

Section: Discussionmentioning

confidence: 96%

Independent Association of High Serum Uric Acid Concentration with Angiographically Defined Coronary Artery Disease

Jelić‐Ivanović

Memon

Spasojević‐Kalimanovska

et al. 2007

Tohoku J. Exp. Med.

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Relationship between coronary risk factor and arteriographic feature of coronary atherosclerosis.

Cited by 16 publications

References 7 publications

Characteristics of Coronary Heart Disease in Japanese Taxi Drivers as Determined by Coronary Angiographic Analyses.

Characteristics of Coronary Heart Disease in Japanese Taxi Drivers as Determined by Coronary Angiographic Analyses.

Serum Uric Acid Independently Predicts Mortality in Patients with Significant, Angiographically Defined Coronary Disease

Independent Association of High Serum Uric Acid Concentration with Angiographically Defined Coronary Artery Disease

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