Independent Association of High Serum Uric Acid Concentration with Angiographically Defined Coronary Artery Disease

Jelić‐Ivanović, Zorana; Memon, Lidija; Spasojević‐Kalimanovska, Vesna; Bogavac-Stanojević, Nataša; Spasić, Slavica

doi:10.1620/tjem.211.369

Cited by 16 publications

(15 citation statements)

References 25 publications

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“…Cardiovascular clinical outcomes and extent of atherosclerotic plaques have been two major end points used in numerous studies in this field to date. After the early work of Allard and Goulet [29], which refuted an association between SUA levels and angiographically proven CAD severity, a number of subsequent investigations [30,31,32,33] suggested a positive independent association, while others did not [34,35,36]. Differences in studied populations, study protocols and methods to detect CAD (electron beam CT, coronary angiography) as well as lack of adjustment for inflammatory markers and other novel cardiovascular risk factors may in part account for discrepancies in the results of these studies.…”

Section: Discussionmentioning

confidence: 99%

Uric Acid and Pentraxin-3 Levels Are Independently Associated with Coronary Artery Disease Risk in Patients with Stage 2 and 3 Kidney Disease

Kanbay¹,

Ikizek²,

Solak³

et al. 2011

Am J Nephrol

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Background and Objectives: Cardiovascular disease is prevalent in chronic kidney disease (CKD). Uric acid is increased in subjects with CKD and has been linked with cardiovascular mortality in this population. However, no study has evaluated the relationship of uric acid with angiographically proven coronary artery disease (CAD) in this population. We therefore investigated the link between serum uric acid (SUA) levels and (i) extent of CAD assessed by the Gensini score and (ii) inflammatory parameters, including C-reactive protein (CRP) and pentraxin-3, in patients with mild-to-moderate CKD. Material and Methods: In an unselected population of 130 patients with estimated glomerular filtration rate (eGFR) between 90 and 30 ml/min/1.73 m², we measured SUA, serum pentraxin-3, CRP, urinary protein-to-creatinine ratio, lipid parameters and the severity of CAD as assessed by coronary angiography and quantified by the Gensini lesion severity score. Results: The mean serum values for SUA, pentraxin-3 and CRP in the entire study population were 5.5 ± 1.5 mg/dl, 6.4 ± 3.4 ng/ml and 3.5 ± 2.6 mg/dl, respectively. The Gensini scores significantly correlated in univariate analysis with gender (R = –0.379, p = 0.02), uric acid (R = 0.42, p = 0.001), pentraxin-3 (R = 0.54, p = 0.001), CRP (R = 0.29, p = 0.006) levels, eGFR (R = –0.33, p = 0.02), proteinuria (R = 0.21, p = 0.01), and presence of hypertension (R = 0.37, p = 0.001), but not with smoking status, diabetes mellitus, and lipid parameters. After adjustments for traditional cardiovascular risk factors, only uric acid (R = 0.21, p = 0.02) and pentraxin-3 (R = 0.28, p = 0.01) remained significant predictors of the Gensini score. Conclusions: SUA and pentraxin-3 levels are independent determinants of severity of CAD in patients with mild-to-moderate CKD. We recommend a clinical trial to determine whether lowering uric acid could prevent progression of CAD in patients with CKD.

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Section: Discussionmentioning

confidence: 99%

Uric Acid and Pentraxin-3 Levels Are Independently Associated with Coronary Artery Disease Risk in Patients with Stage 2 and 3 Kidney Disease

Kanbay¹,

Ikizek²,

Solak³

et al. 2011

Am J Nephrol

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“…After adjusting for confounders, they found differences between the uric acid concentrations in the case vs. control group only in women; no significant differences were observed in men with or without significant coronary lesions in their study. 9 Persky et al studied, the association between uric acid and the prevalence of ECG abnormalities and with mortality appear to be secondary to associations between uric acid and other risk factors in men. 10 Gur M, Yilmaz R, Demirbag R et al studied relation of serum uric acid levels with the presence of angiographic coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

Study of Serum Uric Acid Level as a Risk Factor and for Evaluating the Severity of Coronary Artery Disease

Shruthi¹,

D²,

Mukherjee³

2016

jemds

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“…Although Framingham analysis and Aric study [14,15] showed no relationship between the uric acid and CAD, numerous studies have reported a possible relationship between uric acid and incidence and severity of CAD [16][17][18][19][20]. Previous studies have reported the increased levels of uric acid in CAD patients.…”

Section: Uric Acid and Cadmentioning

confidence: 99%

“…In Iran, Goodarzinejad et al conducted an observational study in Tehran and showed the independent relationship of hyperuricemia with CAD only in men [23]. In some other studies, a signi cant relationship was observed in blood uric acid level and CAD just among women [24][25][26].…”

Section: Uric Acid and Cadmentioning

confidence: 99%

The Relationship between Serum Levels of Vitamin C, Uric Acid and Antioxidant status with Coronary Artery Disease: a Case-Control Study

Torkzaban

Naeini

Hassanzadeh

et al. 2020

Preprint

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Background: Coronary Heart Disease (CHD) is among the main causes of death in adults. Increase of oxidative stress and defects in antioxidant defense play a major role in endothelium performance and are an effective factor in progress of atherosclerosis. The aim of this study is to measure the serum level of UA and vitamin C as well as the antioxidant status of CHD patients to evaluate their relationship and compare them with the healthy individual. Materials and methods:The present case-control study was performed on 44 cases and 44 controls. Demographic data and anthropometric indices were measured. Food frequency questionnaire (FFQ) and international physical activity questionnaire were also completed. After 12 hours of fasting, 10 ml blood was sampled from the participants. Uric acid (UA), vitamin C, TAC and MDA were also measured. The data were finally analyzed by SPSS Ver 22 software.Results: A significant difference was observed between the two groups in terms of uric acid (P<0.001) and vitamin C (P<0.03). However, mean MDA and TAC showed no significant difference between the two groups. The two groups' difference in terms of vitamin A, E and beta carotene, zinc and selenium intake was not significant. A significant difference was however detected between the two groups in terms of vitamin C intake (P<0.047). A significant relationship was also observed between the systolic blood pressure and CHD (P<0.028). Conclusion:Our results suggest that increasing of serum uric acid and a decrease in serum vitamin C level can be considered as risk factors for CHD patients. Due to the lack of significant correlation between TAC and CHD in this study, it seems that different results will be obtained with increasing sample size.

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Independent Association of High Serum Uric Acid Concentration with Angiographically Defined Coronary Artery Disease

Cited by 16 publications

References 25 publications

Uric Acid and Pentraxin-3 Levels Are Independently Associated with Coronary Artery Disease Risk in Patients with Stage 2 and 3 Kidney Disease

Uric Acid and Pentraxin-3 Levels Are Independently Associated with Coronary Artery Disease Risk in Patients with Stage 2 and 3 Kidney Disease

Study of Serum Uric Acid Level as a Risk Factor and for Evaluating the Severity of Coronary Artery Disease

The Relationship between Serum Levels of Vitamin C, Uric Acid and Antioxidant status with Coronary Artery Disease: a Case-Control Study

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