Relationship between Clusters of Differentiation 4 Count and Type of Human Papilloma Virus with Giant Condyloma Acuminata

Abstract

BACKGROUND: Condyloma acuminata (CA) is a sexually transmitted infection caused by the human papilloma virus (HPV). HPV infection is increasing in immunosuppressed patients which causes the development of CA lesions to be longer, recurrent, and larger. Clusters of differentiation 4 (CD4) count showed an association with the occurrence of giant condyloma acuminata (GCA). AIM: The aim of the study was to determine the relationship between CD4 count and type of HPV with GCA. SUBJECTS AND METHODS: This study was an analytic and observational study with a cross-sectional design with 20 human immunodeficiency virus-infected subjects (10 GCA and 10 non-GCA) selected using the consecutive sampling technique. CD4 examination using blood samples which were analyzed using fluorescence-activated cell sorting. CA lesions were taken using a shave biopsy technique and then the HPV type was examined using the polymerase chain reaction method. RESULTS: The majority of the study subjects were male with GCA 7 people (41.2%). The most age group was 26–35 years old with GCA 6 people (66.7%). The education of the subjects was mostly senior high school with GCA 9 people (56.2%). The employment of the subjects was mostly service and sales personnel with GCA 4 people (57.1%). Based on the location of the GCA lesions, there were 4 people (57.1%) in the genital area and 6 people (46.2%) in the anal area. A total of 9 people (90%) with GCA had severe immunosuppression. The results of the analysis showed that there was a significant relationship between CD4 count and GCA (p < 0.001). The most common HPV type in GCA was HPV-11, amounting to 6 people (46.2%). The results of the analysis showed that there was no significant relationship between the type of HPV and GCA (p = 0.275). CONCLUSION: There is a significant relationship between CD4 count with GCA and there is no relationship between type of HPV with GCA.