Relationship between circulating vascular endothelial growth factor and its soluble receptors in adults with dengue virus infection: a case–control study

Seet, Raymond C.S.; Chow, Adeline; Quek, Amy May Lin; Chan, Yiong‐Huak; Lim, Erle C.H.

doi:10.1016/j.ijid.2008.11.028

Cited by 32 publications

(25 citation statements)

References 19 publications

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“…However, many studies have reported the relationship between VEGF and vascular leakage in severely infected dengue patients. [26][27][28] Our previous study reported the evidence of endothelial cells dysfunction/damage by demonstrating elevated soluble thrombomodulin in the febrile stage in DSS patients. 29 Moreover, in this study, we also found significant correlation between VEGF and EGF from day 0 to day +1.…”

Section: Discussionmentioning

confidence: 97%

Alteration of Cytokines and Chemokines During Febrile Episodes Associated With Endothelial Cell Damage and Plasma Leakage in Dengue Hemorrhagic Fever

Butthep

Chunhakan

Yoksan

et al. 2012

Pediatric Infectious Disease Journal

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Section: Discussionmentioning

confidence: 97%

Alteration of Cytokines and Chemokines During Febrile Episodes Associated With Endothelial Cell Damage and Plasma Leakage in Dengue Hemorrhagic Fever

Butthep

Chunhakan

Yoksan

et al. 2012

Pediatric Infectious Disease Journal

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“…However, the discriminatory ability of sFlt-1 was suboptimal: a cut-off level of 16.9 ng/mL had a sensitivity of 52% and a specificity of 84% for the diagnosis of occult placental malaria. Finally, in patients with dengue virus infection, serum sFlt-1, but not VEGF, differentiated between patients with dengue fever and dengue hemorrhagic fever 97 . At a cut-off value of 350 pg/mL, sFlt-1 levels predicted dengue hemorrhagic fever with a sensitivity of 79% and a specificity of 78%.…”

Section: Mediators Of Vascular Tone and Permeability: Vegf And Sflt-1mentioning

confidence: 89%

Biomarkers of endothelial activation/dysfunction in infectious diseases

2013

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Endothelial dysfunction contributes to the pathogenesis of a variety of potentially serious infectious diseases and syndromes, including sepsis and septic shock, hemolytic-uremic syndrome, severe malaria, and dengue hemorrhagic fever. Because endothelial activation often precedes overt endothelial dysfunction, biomarkers of the activated endothelium in serum and/or plasma may be detectable before classically recognized markers of disease, and therefore, may be clinically useful as biomarkers of disease severity or prognosis in systemic infectious diseases. In this review, the current status of mediators of endothelial cell function (angiopoietins-1 and -2), components of the coagulation pathway (von Willebrand Factor, ADAMTS13, and thrombomodulin), soluble cell-surface adhesion molecules (soluble E-selectin, sICAM-1, and sVCAM-1), and regulators of vascular tone and permeability (VEGF and sFlt-1) as biomarkers in severe infectious diseases is discussed in the context of sepsis, E. coli O157:H7 infection, malaria, and dengue virus infection.

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“…One originality of this study is that, contrary to previous reports, soluble factors level were measured throughout the acute phase [14,18,21-23,49,50]. Chemokines are produced by activated monocytes and macrophages, which are known DENV target cells [51].…”

Section: Discussionmentioning

confidence: 99%

Acute dengue virus 2 infection in Gabonese patients is associated with an early innate immune response, including strong interferon alpha production

et al. 2010

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BackgroundDengue is now a leading cause of morbidity and mortality throughout the tropics. We conducted the first ex vivo study of dengue fever (DF) in African patients infected during the first Gabonese dengue virus 2 (DENV-2) outbreak in 2007, in order to investigate cytokine production, including the antiviral cytokine IFN-α, reported to be a potent inhibitor of DENV replication in vitro.MethodsLevels of 50 cytokines, chemokines and growth factors were measured in plasma from 36 patients with DENV-2 infection, and in uninfected controls, using Luminex multiplex technology. The results were interpreted according to the day of sampling after symptom onset. PBMC from six patients were also studied for T lymphocyte cell surface marker expression by flow cytometry.ResultsAcute DENV-2 infection elicited high levels of several pro-inflammatory cytokines (IL-6 and IL-17), chemokines (MIF, RANTES, IP-10 and MCP-1) and growth factors (G-CSF, GM-CSF and VEGF-A). We also observed high levels of IFN-α for the first time in adult DF patients, and CD4+ and CD8+ T cell activation at symptom onset.ConclusionAcute DENV-2 infection in African patients elicits a strong innate response involving IFN-α production, as well as an adaptive immune response.

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Relationship between circulating vascular endothelial growth factor and its soluble receptors in adults with dengue virus infection: a case–control study

Abstract: The changes in VEGF and its soluble receptors highlight the importance of vascular permeability cytokines in the pathogenesis of DHF.

Cited by 32 publications

References 19 publications

Alteration of Cytokines and Chemokines During Febrile Episodes Associated With Endothelial Cell Damage and Plasma Leakage in Dengue Hemorrhagic Fever

Alteration of Cytokines and Chemokines During Febrile Episodes Associated With Endothelial Cell Damage and Plasma Leakage in Dengue Hemorrhagic Fever

Biomarkers of endothelial activation/dysfunction in infectious diseases

Acute dengue virus 2 infection in Gabonese patients is associated with an early innate immune response, including strong interferon alpha production

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