Alteration of Cytokines and Chemokines During Febrile Episodes Associated With Endothelial Cell Damage and Plasma Leakage in Dengue Hemorrhagic Fever

Butthep, Punnee; Chunhakan, Sirichan; Yoksan, Sutee; Tangnararatchakit, Kanchana; Chuansumrit, Ampaiwan

doi:10.1097/inf.0b013e31826fd456

Cited by 96 publications

(107 citation statements)

References 26 publications

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“…The rest of studies reported no statistical difference or did not detect TNFa. By contrast, IL-10 stood out as the cytokine for which concentration was elevated in DHF relative to DF patients consistently in seven studies utilizing the WHO (1986)/WHO (1997) case definition (Table 3) (Brasier et al, 2012;Butthep et al, 2012;Chen et al, 2005;Green et al, 1999b;Houghton-Triviño et al, 2010;Nguyen et al, 2004;P erez et al, 2004). The association of dengue severity with circulating levels of IFNg was more heterogeneous (Table 4) (Bozza et al, 2008;Butthep et al, 2012;Chen et al, 2005;Nguyen et al, 2004;Soundravally et al, 2014).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The association of dengue severity with circulating levels of IFNg was more heterogeneous (Table 4) (Bozza et al, 2008;Butthep et al, 2012;Chen et al, 2005;Nguyen et al, 2004;Soundravally et al, 2014). Three studies noted increased IFNg in DHF and/or DSS patients relative to DF patients or healthy controls (Bozza et al, 2008;Butthep et al, 2012;Nguyen et al, 2004), whereas three studies noted decreased IFNg levels in DHF/DSS over DF patients (Chen et al, 2005;Soundravally et al, 2014). Bozza et al (2008) noted defervescence phase IFNg levels in adults (age 15-73 years) were associated with disease severity (odds ratio=1.138, 95 %confidence interval1.041 to 1.245, P=0.0046).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Ten studies noted affirmatively that their first blood sampling was performed at the febrile phase, which we defined here as <5 days or <96 h from fever onset (Brasier et al, 2012;Butthep et al, 2012;Green et al, 1999a, b;De La Cruz Hern andez et al, 2014;Malavige et al, 2013a;P erez et al, 2004;Soundravally et al, 2014;Wang et al, 2007). The remaining studies had wider blood sampling windows, ranging from 1 to 10 days from symptom onset (Arias et al, 2014;Bozza et al, 2008;Chen et al, 2005;de-Oliveira-Pinto et al, 2012;Guerrero et al, 2013;Houghton-Triviño et al, 2010;Kurane et al, 1991Kurane et al, , 1993Laur et al, 1998;Levy et al, 2010;Del Moral-Hern andez et al, 2014;Nguyen et al, 2004;Suharti et al, 2003).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…By contrast, IL-10 stood out as the cytokine for which concentration was elevated in DHF relative to DF patients consistently in seven studies utilizing the WHO (1986)/WHO (1997) case definition (Table 3) (Brasier et al, 2012;Butthep et al, 2012;Chen et al, 2005;Green et al, 1999b;Houghton-Triviño et al, 2010;Nguyen et al, 2004;P erez et al, 2004). The association of dengue severity with circulating levels of IFNg was more heterogeneous (Table 4) (Bozza et al, 2008;Butthep et al, 2012;Chen et al, 2005;Nguyen et al, 2004;Soundravally et al, 2014). Three studies noted increased IFNg in DHF and/or DSS patients relative to DF patients or healthy controls (Bozza et al, 2008;Butthep et al, 2012;Nguyen et al, 2004), whereas three studies noted decreased IFNg levels in DHF/DSS over DF patients (Chen et al, 2005;Soundravally et al, 2014).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…A total of 19 out of 24 studies were case-control studies (Arias et al, 2014;Bozza et al, 2008;Brasier et al, 2012;Butthep et al, 2012;Chen et al, 2005;Furuta et al, 2012;Green et al, 1999a, b;Guerrero et al, 2013;Houghton-Triviño et al, 2010;De La Cruz Hern andez et al, 2014;Laur et al, 1998;Levy et al, 2010;Malavige et al, 2013a;Nguyen et al, 2004;Del Moral-Hern andez et al, 2014;P erez et al, 2004;Soundravally et al, 2014;Wang et al, 2007), and the remaining 5 studies were prospective cohort studies (de-Oliveira-Pinto et al, 2012;Kurane et al, 1991Kurane et al, , 1993Suharti et al, 2003). Comparison groups were healthy controls, patients with other febrile illness (OFI) or non-severe disease patients (DF or non-SD); however, comparisons made between SD and non-SD cases were considered most ideal for the purpose of this review.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 4 more Smart Citations

Markers of dengue severity: a systematic review of cytokines and chemokines

Lee

Leong

Wilder‐Smith

2016

Journal of General Virology

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The prognosis of dengue remains a challenge in the early, objective triage of patients with dengue fever of differing severity. Circulating immuno-modulating proteins have brought new possibilities as prognostic markers of severe dengue (SD). This systematic review is devoted to understanding the potential utility of blood-based cytokines and chemokines as prognostication markers of SD based on the current literature. PubMed and Embase were searched. Of 794 candidate articles, 685 abstracts were screened against our exclusion/inclusion criteria and 25 (3.6 %) studies met the quality assessments. A total of 18 studies were retrospective observational and 2 were prospective cohort studies. Elevated IL-10, up to day 7 of fever onset, stood out as a candidate prognostic marker for SD using the 1997 and 2009 World Health Organization (WHO) case definitions. IFNg was another potential prognostic marker of SD (1997 WHO case definition), but its levels varied between studies. Significant heterogeneity in methodologies and patient cohorts prevent ready application of IL-10 and IFNg as prognostic markers to other dengue populations. Our results suggest that the current non-randomized studies are delivering inconsistent messages and higher-quality studies, with consistent methodologies and validation in independent patient cohorts, are needed to delineate confounding variables. Major gaps identified were full accounting and transparency of sampling days, dengue virus type, infection status and age group.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Markers of dengue severity: a systematic review of cytokines and chemokines

Lee

Leong

Wilder‐Smith

2016

Journal of General Virology

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Demethylation profile of the TNF-α promoter gene is associated with high expression of this cytokine inDengue viruspatients

et al. 2016

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Dengue is the most prevalent arthropod-borne viral illness in humans. The overexpression of cytokines by Dengue virus (DENV) infected cells is associated with the most severe forms of the disease. Unmethylated CpG islands are related to a transcriptionally active structure, whereas methylated DNA recruits methyl-binding proteins that inhibit gene expression. Several studies have described the importance of epigenetic events in the regulation and expression of many cytokines. The purpose of the present study was to evaluate the methylation status of the IFN-γ and TNF-α promoters in DNA extracted from dengue infected patients using methylation-specific polymerase chain reaction. A high frequency of demethylation was observed in the TNF-α promoter of DENV infected patients when compared to non-infected controls. The patients with an unmethylated profile showed higher expression of TNF-α mRNA than patients with the methylated status. No difference was found in the methylation frequency between the two analyzed groups regarding the IFN-γ promoter or in the expression of IFN-γ transcripts. The present study provides the first association of TNF-α promoter demethylation in DENV infected individuals and demonstrates a correlation between the methylation status of the region analyzed and the expression of TNF-α transcripts in DENV infected patients. J. Med. Virol. 88:1297-1302, 2016. © 2016 Wiley Periodicals, Inc.

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Viral coinfections in COVID‐19

Aghbash

Eslami

Shirvaliloo

et al. 2021

Journal of Medical Virology

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The most consequential challenge raised by coinfection is perhaps the inappropriate generation of recombinant viruses through the exchange of genetic material among different strains. These genetically similar viruses can interfere with the replication process of each other and even compete for the metabolites required for the maintenance of the replication cycle. Due to the similarity in clinical symptoms of most viral respiratory tract infections, and their coincidence with COVID‐19, caused by SARS‐CoV‐2, it is recommended to develop a comprehensive diagnostic panel for detection of respiratory and nonrespiratory viruses through the evaluation of patient samples. Given the resulting changes in blood markers, such as coagulation factors and white blood cell count following virus infection, these markers can be of diagnostic value in the detection of mixed infection in individuals already diagnosed with a certain viral illness. In this review, we seek to investigate the coinfection of SARS‐CoV‐2 with other respiratory and nonrespiratory viruses to provide novel insights into the development of highly sensitive diagnostics and effective treatment modalities.

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Alteration of Cytokines and Chemokines During Febrile Episodes Associated With Endothelial Cell Damage and Plasma Leakage in Dengue Hemorrhagic Fever

Cited by 96 publications

References 26 publications

Markers of dengue severity: a systematic review of cytokines and chemokines

Markers of dengue severity: a systematic review of cytokines and chemokines

Demethylation profile of the TNF-α promoter gene is associated with high expression of this cytokine inDengue viruspatients

Viral coinfections in COVID‐19

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