Relationship between Chronic Periodontitis and Erectile Dysfunction: A Narrative Review

Abstract

Objective. To conduct a descriptive literature review on research studies investigating the association between chronic periodontitis (CP) and erectile dysfunction (ED).Methods. Cohort studies, case-control studies, cross-sectional studies, randomized control trials, and animal studies up to July 2015 that studied the relationship between CP and ED were reviewed and reported. Data sources included PubMed, EMBASE, Cochrane Library, and Clinicaltrials.gov. The themes “periodontal disease” and “erectile dysfunction” and the role of periodontal therapy were identified and discussed throughout the narrative review.Results. After reviewing the literature, it was found that an association between CP and vasculogenic ED likely exists. Inflammation resulting from CP promotes endothelial dysfunction by increasing the systemic levels of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α). Periodontal therapy attempts to decrease the release of TNF-αand could act to restore endothelial function, particularly in the penile vasculature.Conclusion. Although the literature reported a positive association between CP and ED, the studies were few and possess several methodological limitations. Large-scale cohort studies and confounder analysis are recommended. Dentists and physicians should collaborate to manage patients with either CP or ED because of their potential association not only with each other but also with other serious systemic comorbidities.

Oral health and erectile dysfunction

“…Furthermore, evidence from recent systematic reviews[ 35 36 ] and meta-analysis[ 37 ] of available literature also revealed the positive association between CP and ED. The pooled odd-ratio of the included studies in meta-analysis[ 37 ] showed that patients with ED were 3.07-fold more likely than controls to be diagnosed with CP.…”

Revisión Bibliográfica: Disfunción Eréctil y Enfermedad Periodontal

“…La DE puede ser causada por factores orgánicos, psicogénicos o mixtos [5]. Dentro de los factores orgánicos se incluyen: la disfunción vasculogénica, neurogénica, endocrinológica, la alteración del músculo liso cavernoso, los traumas iatrogénicos y la disfunción inducida por fármacos [6,7]. Se estima que la DE se presenta con una prevalencia del 3% al 76.5% en la población masculina global, incrementando en sentido lineal en relación con la edad [8].…”

The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis

“…Evidence suggests shared risk factors between PD and ED, including diabetes, smoking, hypertension, and coronary heart disease (Oğuz et al, 2013; Shariff et al, 2016; Sharma et al, 2011; Singh et al, 2017). Literature supports a pathophysiological link between ED and PD, such as systemic inflammation, oxidative stress, and endothelial dysfunction.…”

“…Literature supports a pathophysiological link between ED and PD, such as systemic inflammation, oxidative stress, and endothelial dysfunction. Periodontal treatment may result in an improvement of endothelial function by reducing the level of systemic biomarkers (Changal et al, 2019; Shariff et al, 2016; Singh et al, 2017). Animal studies indicated a decrease in the expression of endothelial nitric oxide synthase (eNOS) and NOS activity in penile cavernous tissue, caused by a mild systemic inflammatory status in periodontitis as a possible mechanism for the effect of periodontitis on penile erection (Zuo et al, 2011).…”