The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis

Farook, Fathima Fazrina; Meshrafi, Azzam Al; Nizam, Nuzaim Mohamed; Shammari, Abdulsalam Al

doi:10.1177/15579883211007277

Cited by 6 publications

(5 citation statements)

References 33 publications

(54 reference statements)

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“…[ 59 ] Multiple studies have shown a reduction in TNF-α levels after successful periodontal treatment, and evident that significant higher plasma levels of TNF-α were associated with moderate to severe ED owing to their known effects on the vasculature. [ 60 , 61 ] Management of the oral biofilm and periodontal health can therefore have positive implications in management of ED.…”

Section: Erectile Dysfunction (Ed)mentioning

confidence: 99%

The systemic oral health connection: Biofilms

Kurtzman¹,

Horowitz

Johnson³

et al. 2022

Medicine

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Frequently, periodontal health and it's associated oral biofilm has not been addressed in those patients who have systemic health issues, especially those who are not responding to medical treatment via their physician. Oral biofilm may be present in the periodontal sulcus in the absence of clinical disease of periodontal disease (bleeding on probing, gingival inflammation) and periodontal reaction is dependent on the patient's immune response to the associated bacterial and their byproducts. Increasing evidence has been emerging the past decade connecting oral biofilm with systemic conditions, either initiating them or complicating those medical conditions. The patient's health needs to be thought of as a whole-body system with connections that may originate in the oral cavity and have distant affects throughout the body. To maximize total health, a coordination in healthcare needs to be a symbiosis between the physician and dentist to eliminate the oral biofilm and aid in prevention of systemic disease or minimize those effects to improve the patient's overall health and quality of life. Various areas of systemic health have been associated with the bacteria and their byproducts in the oral biofilm. Those include cardiovascular disease, chronic kidney disease, diabetes, pulmonary disease, prostate cancer, colon cancer, pancreatic cancer, pre-term pregnancy, erectile dysfunction Alzheimer's disease and Rheumatoid arthritis. This article will discuss oral biofilm, its affects systemically and review the medical conditions associated with the oral systemic connection with an extensive review of the literature.

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Section: Erectile Dysfunction (Ed)mentioning

confidence: 99%

The systemic oral health connection: Biofilms

Kurtzman¹,

Horowitz

Johnson³

et al. 2022

Medicine

View full text Add to dashboard Cite

show abstract

“…124,125 Multiple studies have reported a reduction in TNF-α levels after successful periodontal treatment, and it is evident that significantly higher plasma levels of TNF-α were associated with moderate to severe ED owing to their known effects on the vasculature. 126,127 Management of oral biofilm and periodontal health can therefore have positive implications in the management of ED.…”

Section: Erectile Dysfunction (Ed)mentioning

confidence: 99%

Oral Biofilms and their Connection to Systemic Health

Kurtzman¹,

Horowitz

Johnson³

et al. 2022

MRAJ

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Systemic and oral health are interconnected via bacteria and their byproducts which can circulate throughout the body which are found in the oral biofilm. Oral biofilm and its associated periodontal health have not been frequently addressed in patients with systemic health issues. This is especially true for those patients who do not respond to medical treatment via their physician for systemic issues. The periodontal sulcus in the absence of clinical presence of periodontal disease (bleeding on probing, gingival inflammation) may have oral biofilm present. Periodontal reaction is dependent on the patient’s immune response to the associated bacteria and their byproducts present in the oral biofilm. Increasing evidence has emerged in recent years that are connecting oral biofilms with systemic conditions, either by initiating them or by complicating those medical conditions. Patient health needs to be considered as a whole-body system with connections that may originate in the oral cavity and have distant effects throughout the body. In order to maximize the patient’s total health, healthcare needs to be a coordination between the physician and dentist to eliminate the oral biofilm and aid in the prevention of systemic disease or minimize these effects to improve the overall patient health and their quality of life. Various systemic health areas have been associated with the bacteria in oral biofilms and their byproducts. Those include cardiovascular disease, chronic kidney disease, diabetes, pulmonary disease, prostate cancer, colon cancer, pancreatic cancer, pre-term pregnancy, erectile dysfunction, Alzheimer’s disease, and rheumatoid arthritis. This article will discuss oral biofilm, its systemic effects, and review the medical conditions associated with the oral systemic connection with an extensive review of the literature to aid in demonstrating the total body connection.

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“…7 Indeed, Uppal et al 8 found an association between the presence of periodontitis and ED, and Oğuz et al 9 suggested chronic periodontitis as an additional risk factor for ED.In contrast, Sharma et al 10 did not find a significant association between ED and the presence of periodontitis. Furthermore, recent systematic reviews by Farook et al 11 and Lecaplain et al 12 showed an association between periodontitis and ED. However, the effect of confounding factors and recall bias remain major limitations to the studies considered in these reviews.…”

Section: Introductionmentioning

confidence: 98%

Periodontitis as a risk factor for organic erectile dysfunction: A case-control study in a sub-Saharan population

Diouf,

Ndjidda Bakari,

Sounlin

et al. 2023

J Adv Periodontol Implant Dent

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Background. This study investigated the association between periodontitis and organic erectile dysfunction (ED) in a sub-Saharan population. Methods. This multicenter analytical study lasted from April to September 2021. A total of 114 patients (38 cases and 76 controls) were recruited and matched on age, diabetes, and smoking status. Medical history and ED were recorded, as well as the plaque index, bleeding index, maximum interdental clinical attachment loss (CALmax), maximum probing depth, clinically detectable furcation involv ement, number of teeth in the mouth, number of teeth lost for periodontal reasons, and tooth mobility. The analysis was performed with SPSS 20.0 with a significance threshold set at 5%. Results. The two study groups were comparable regarding sociodemographic characteristics. Periodontitis was present in 76.31% of cases and 75% of controls without a significant difference (P=0.878). Logistic regression showed a significant association between high blood pressure and ED with an OR=4.78 (95% CI: 1.80‒12.70). Periodontitis was not associated with ED (OR=1.52, 95% CI: 0.55‒4.16); however, severe periodontitis was significantly associated with severe ED (OR=1.44, 95% CI: 1.11‒1.85, and OR=1.68, 95% CI: 1.15‒2.44, respectively for CALmax and tooth loss). Conclusion. Within the limits of this study, periodontitis was not associated with organic ED. However, the severity of periodontal disease significantly increased in patients with organic ED.

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The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis

Cited by 6 publications

References 33 publications

The systemic oral health connection: Biofilms

The systemic oral health connection: Biofilms

Oral Biofilms and their Connection to Systemic Health

Periodontitis as a risk factor for organic erectile dysfunction: A case-control study in a sub-Saharan population

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