Relationship Between Central Corneal Thickness and Ganglionic-Inner Plexiform Cell Layer and Retinal Nerve Fibre Layer Thickness in Normal Subjects

Abstract

Purpose To determine the relationship between central corneal thickness (CCT), ganglionic cell-inner plexiform layer thickness and macular nerve fibre layer (RNFL) thickness as measured by optical coherence tomography in a cohort of healthy subjects. Methods Sixty healthy eyes from 60 subjects were included in this study. All subjects had a standard slit-lamp examination and optical coherence tomography. Central corneal thickness was measured using the Optopol spectral domain optical coherence tomography (SD OCT) machine (version 7.2.0). A linear mixed effects model was used to assess the relationship between central corneal thickness (CCT) and ganglionic cell-inner plexiform layer thickness and macular retinal nerve fibre layer thickness (RNFL). Results Sixty healthy eyes from 60 subjects were included in this study. The average age was 41.8 years (±20.6 years). There were 22 males (37%) and 38 females (63%). The average central corneal thickness was 525.2 ± 35.1 µm (451–601) µm. The average macular retinal nerve fiber layer thickness was 28.9 ± 2.5 µm (23–38µm), and the average ganglionic cell-inner plexiform layer thickness was 88.6 ± 6.3 µm (75–110 µm). We found no statistically significant relationship between central corneal thickness and ganglionic cell-inner plexiform layer thickness (p=0.983) nor with macular RNFL (p =0.285). Conclusion In this cohort of healthy subjects, there was no statistically significant relationship between central corneal thickness and ganglionic cell-inner plexiform layer thickness or with macular retinal nerve fibre layer thickness.

Associated Factors and Distribution of Peripapillary Retinal Nerve Fiber Layer Thickness in Children by Optical Coherence Tomography: A Population-based Study

“…Few studies have examined the association between CCT and RNFL thickness in healthy individuals and reported different results. The results of studies performed on healthy individuals mainly indicate no significant association between CCT and RNFL thickness or an inverse association between these 2 parameters 59–61. Given the low regression coefficient in the final model in the present study, the association between CCT and RNFL thickness in children does not seem to be clinically significant.…”

Relationship between Central Corneal Thickness, Intra-Ocular Pressure, Retinal Nerve Fiber Layer Thickness and Ganglion Cell Layer Thickness in Primary Open Angle Glaucoma

“…That is not surprising considering their anatomical and physiological independence as they explain this finding in their study. 8 The current result showed that there was significant negative correlation between corrected IOP and total RNFL in the studied POAG patients (r= -0.547, p<0.001). There was significant negative association between corrected IOP and superior RNFL in the studied POAG patients (r= -0.559, p<0.001), and there was significant negative association between corrected IOP and inferior RNFL in the studied POAG patients (r= -0.501, p<0.001).…”