Relationship between Central Corneal Thickness, Intra-Ocular Pressure, Retinal Nerve Fiber Layer Thickness and Ganglion Cell Layer Thickness in Primary Open Angle Glaucoma

Abstract

Background: Primary open angle glaucoma is a multifactorial disorder characterised by the death of retinal ganglion cells, which results in a characteristic optic neuropathy and concomitant visual field reduction. Aim of The Work: to determine the association between central corneal thickness, intraocular pressure, peri-papillary retinal nerve fiber layer thickness, and ganglion cell layer thickness in patients with primary open angle glaucoma. Patients and Methods: A cross-sectional observational study included 60 eyes of 36 patients with primary open angle glaucoma conducted at

Macular Thickness and Volume Analysis in Primary Open Angel Glaucoma by Optical Coherence Tomography

“…RNFL measurements showed high significance regarding RNFL (inferior, superior, nasal) , macular thickness measurements showed significant macular thickness at (fovea, inner superior, inner inferior, inner nasal, inner temporal, outer superior, outer inferior, outer nasal, and outer temporal) and macular volume measurements showed significant macular volume at( fovea, inner superior, inner inferior, inner nasal, inner temporal, outer superior, outer inferior, outer nasal and outer temporal) in control group than glaucoma group Recent studies show that thinning of RNFL is related to the thinning of macular ganglion cell complex (GCC), which is defined as three innermost retinal layers: (1) RNFL (made of ganglion cell axons), (2) ganglion cell layer (GCL) made of ganglion cell bodies and (3) the inner plexiform layer (IPL) made out of ganglion cell dendrites. All three layers of ganglion cell complex are significantly thinner in glaucoma patients, reflecting the proportion of dead ganglion cells 8,9 .…”