Relationship between carotid artery sclerosis and blood pressure variability in essential hypertension patients

Xianglin, Chi; Li, Min; Zhan, Xia; Man, Honghao; Xu, Shiqi; Zheng, Dingchang; Bi, Jianzhong; Wang, Yingcui; Liu, Chengyu

doi:10.1016/j.compbiomed.2017.03.012

Cited by 16 publications

(8 citation statements)

References 31 publications

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“…These data are broadly consistent with the global trend in lower middle-income countries [21]. Well known that BP VVV is associated with cardiovascular risk factors [24], AH-mediated target organ damage [12,13,[25][26][27] and major adverse CVD events [9,10,28], thus seems to be of crucially importance at different stages of CVD continuum. The present study, enrolled predominantly young and middle-age males with uncomplicated AH, demonstrated that HBPV was associated with more pronounced AH-mediated subclinical target organ damage, namely the LV mass index, carotid arteries and kidneys, which was in agreement with other available studies [12,13,[25][26][27].…”

Section: Discussionsupporting

confidence: 87%

“…Well known that BP VVV is associated with cardiovascular risk factors [24], AH-mediated target organ damage [12,13,[25][26][27] and major adverse CVD events [9,10,28], thus seems to be of crucially importance at different stages of CVD continuum. The present study, enrolled predominantly young and middle-age males with uncomplicated AH, demonstrated that HBPV was associated with more pronounced AH-mediated subclinical target organ damage, namely the LV mass index, carotid arteries and kidneys, which was in agreement with other available studies [12,13,[25][26][27]. Moreover, HBPV was also associated with more advanced hypertensive retinopathy, that may reflect potential pathophysiological associations of BP variability with retinal microvascular abnormalities in AH [29,30].…”

Section: Discussionmentioning

confidence: 99%

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Visit-to-Visit Blood Pressure Variability and Target Organ Damage in Rural Dwellers With Uncomplicated Arterial Hypertension

et al. 2020

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The aim: To examine the association of hypertensive mediated target organ damage with blood pressure visit-to-visit variability in Ukrainian rural dwellers with uncomplicated hypertension. Material and methods: The cross-sectional study enrolled 160 adult males with uncomplicated primary hypertension (mean age 50±6 yo). We analyzed office systolic and diastolic blood pressure levels, obtained at four consecutive visits. We used standard deviation (SD) value to assess blood pressure visit-to-visit variability. The patients were referred to the group with high (n=82; 51.3%) vs low (n=78; 48.7%) blood pressure variability (HBPV, LBPV). Results: HBPV patients were characterized by higher left ventricular myocardial mass indexed to height 2.7: median, interquartile range: 70.9 (61.3-78.2) vs 50.9 (44.9-54.4) g/m2.7, respectively p<0.001. The cases of severe left ventricular hypertrophy prevailed in HBPV group (vs LBPV): 68% vs 5%, respectively, p<0.001. HBPV group was characterized by larger common carotid artery intima-media complex thickness, advanced hypertensive retinopathy, higher urine albumin/creatinine ratio value and worse kidneys’ glomerular filtration rate. The obtained results might be helpful in the context of global monitoring of vulnerable high risk population of hypertensive rural males. Conclusions: The HBPV in rural hypertensive males was associated with more pronounced target organ damage. Further regional research on the various clinical aspects of hypertension, including blood pressure variability, might be useful in extending the existed evidence on prevention of hypertension-related complications.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Visit-to-Visit Blood Pressure Variability and Target Organ Damage in Rural Dwellers With Uncomplicated Arterial Hypertension

et al. 2020

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“…This study investigated the association between short-term BPV and intracranial IPH in ischemic stroke with intracranial atherosclerosis. The results in our study revealed the following key findings: (1) the distinct effects of blood pressure and its variability on atherosclerosis in different population 25,26) . In young patients without end organ damage, blood pressure management is more important, however, in those hypertensive patients who have already presented multi-organ damage, BPV is much more important in predicting short-term stroke risk.…”

Section: Discussionsupporting

confidence: 57%

Association between Short-Term Blood Pressure Variability and Intracranial Atherosclerotic Plaque Vulnerability: A High-Resolution Magnetic Resonance Imaging Study

Song

Qiao

Zhao

et al. 2022

JAT

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Aim: short-term blood pressure variability (BPV) as a risk factor of atherosclerosis and cardiovascular events has been investigated. However, its association with atherosclerotic plaque vulnerability remains unknown. The objective of this study was to determine the association between short-term BPV and intracranial atherosclerotic plaque vulnerability.Methods: this is a cross-sectional analysis of 267 ischemic stroke patients with symptomatic intracranial atherosclerosis (mean age, 65±12 years old; 60.3% male), which were prospectively recruited in a comprehensive stroke center. Systolic and diastolic BP SD, CV, and BP variability ratio (BPVR) from 24 hours, daytime, and nighttime were calculated from 24-h ambulatory blood pressure monitoring, intracranial atherosclerotic plaque burden and vulnerability were evaluated by high-resolution magnetic resonance vessel wall imaging. Logistic regression analysis was used to locate the correlation between short-term BPV and plaque vulnerability.Results: a total of 36.3% subjects presented with intraplaque hemorrhage (IPH) in this study. Multivariate logistic regression suggested that nighttime diastolic BP CV and 24-h BPVR were associated with intracranial IPH independently after adjusted for cardiovascular risk factors, odds ratio (OR) and 95% confidence interval (CI) for per SD BPV changes were 1.418 (1.051, 1.914) and 0.731 (0.548, 0.976), respectively, and this association also independent of atherosclerosis burden and 24-h mean systolic BP level. Further subgroup analysis by age and hypertension history demonstrated that the statistical correlation could only establish in the elder, and subjects with hypertension. Conclusion: nighttime diastolic BP CV and 24-h BPVR were associated with intracranial IPH independently, especially in the elderly and subjects with hypertension.studies (1359 subjects) analyzed the effects of shortterm BPV on stroke outcome, and concluded that higher systolic BP SD is associated with stroke prognosis 1) . BP and BPV could possibly induced cardiovascular events by atherosclerosis and vulnerableCopyright©2022 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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“…Full‐text versions of the remaining 73 articles were retrieved and singularly examined. Ultimately, 47 studies were excluded and, of the remaining 26 papers that were included, 22 were selected for quantitative analysis . Secondary endpoints (i.e.…”

Section: Resultsmentioning

confidence: 99%

Association between blood pressure variability, cardiovascular disease and mortality in type 2 diabetes: A systematic review and meta‐analysis

Chiriacò

Pateras

Virdis

et al. 2019

Diabetes Obesity Metabolism

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Aim To investigate the associations of blood pressure variability (BPV), expressed as long‐term (visit‐to‐visit) and short‐term (ambulatory blood pressure monitoring [ABPM] and home blood pressure monitoring [HBPM]) and all‐cause mortality, major adverse cardiovascular events (MACEs), extended MACEs, microvascular complications (MiCs) and hypertension‐mediated organ damage (HMOD) in adult patients with type 2 diabetes. Materials and methods PubMed, Medline, Embase, Cinahl, Web of Science, http://clinicaltrials.gov and grey literature databases were searched for studies including patients with type 2 diabetes, at least one variable of BPV (visit‐to‐visit, HBPM, ABPM) and evaluation of the incidence of at least one of the following outcomes: all‐cause mortality, MACEs, extended MACEs and/or MiCs and/or HMOD. The extracted information was analyzed using random effects meta‐analysis and meta‐regression. Results Data from a total of 377 305 patients were analyzed. Systolic blood pressure (SBP) variability was associated with a significantly increased risk of all‐cause mortality (HR 1.12, 95% CI 1.04–1.21), MACEs (HR 1.01, 95% CI 1.04–1.17), extended MACEs (HR 1.07, 95% CI 1.03–1.11) and MiCs (HR 1. 12, 95% CI 1.01–1.24), while diastolic blood pressure was not. Associations were mainly driven from studies on long‐term SBP variability. Qualitative analysis showed that BPV was associated with the presence of HMOD expressed as carotid intima‐media thickness, pulse wave velocity and left ventricular hypertrophy. Results were independent of mean blood pressure, glycaemic control and serum creatinine levels. Conclusions Our results suggest that BPV might provide additional information rather than mean blood pressure on the risk of cardiovascular disease in patients with type 2 diabetes.

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Relationship between carotid artery sclerosis and blood pressure variability in essential hypertension patients

Cited by 16 publications

References 31 publications

Visit-to-Visit Blood Pressure Variability and Target Organ Damage in Rural Dwellers With Uncomplicated Arterial Hypertension

Visit-to-Visit Blood Pressure Variability and Target Organ Damage in Rural Dwellers With Uncomplicated Arterial Hypertension

Association between Short-Term Blood Pressure Variability and Intracranial Atherosclerotic Plaque Vulnerability: A High-Resolution Magnetic Resonance Imaging Study

Association between blood pressure variability, cardiovascular disease and mortality in type 2 diabetes: A systematic review and meta‐analysis

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