Relationship between Cardiorespiratory Fitness and Non-High-Density Lipoprotein Cholesterol: A Cohort Study

Watanabe, Nobuhisa; Sawada, Susumu S.; Shimada, Kazunori; Lee, I-Min; Gando, Yuko; Momma, Haruki; Kawakami, Ryoko; Miyachi, Motohiko; Hagi, Yumiko; Kinugawa, Chihiro; Okamoto, Takashi; Tsukamoto, Koji; Blair, Steven N.

doi:10.5551/jat.43851

Cited by 15 publications

(18 citation statements)

References 33 publications

(41 reference statements)

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“…LPL activity was associated with reduced TG uptake and decreased HDL-C levels 24 ) . In contrast, the response of lipids and lipoproteins was improved by physical activity, including regular aquatic endurance 25 ) , cardiorespiratory exercise 26 ) , and fitness aerobic exercise 27 ) . These studies show that sedentary time and physical activity has a significant effect on lipid metabolism, which is consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study

Koyama

Kuriyama

Ozaki

et al. 2020

JAT

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Aim: Accumulating evidence reveals that sedentary behavior is associated with mortality and cardiometabolic disease; however, there are potential age and sex differences in sedentary behavior and health outcomes that have not been adequately addressed. This study aimed to determine the association of sedentary behavior with cardiometabolic diseases such as hypertension, dyslipidemia, diabetes mellitus, and its risk factors in a large Japanese population according to age and sex. Methods: Using data from the Japan Multi-Institutional Collaborative Cohort Study obtained from baseline surveys, data of 62,754 participants (27,930 males, 34,824 females) were analyzed. This study uses a cross-sectional design and self-administered questionnaires to evaluate sedentary time and anamnesis. For the logistic regression analysis, sedentary time 5 h/day was used as the reference and then adjusted for age, research areas, leisure-time metabolic equivalents, and alcohol and smoking status. From the analysis of anthropometric and blood examinations, 35,973 participants (17,109 males, 18,864 females) were analyzed.Results: For hypertension and diabetes, sedentary time was associated with a significantly higher proportion of male participants. Both sexes were associated with a significantly higher proportion of participants with dyslipidemia. Participants who had longer sedentary time tended to have increased levels of blood pressure, triglycerides, and non-high-density lipoprotein cholesterol (HDL-C), and decreased levels of HDL-C, especially in the 60-69 years group.Conclusions: Independent of leisure-time physical activity, sedentary time was associated with cardiometabolic diseases in a large Japanese population classified by age and sex. Our findings indicate that regularly interrupting and replacing sedentary time may contribute to better physical health-related quality of life.

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Section: Discussionmentioning

confidence: 99%

Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study

Koyama

Kuriyama

Ozaki

et al. 2020

JAT

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“…Although it has been reported that the addition of milk, the type of coffee bean, and the type of roasting method do not alter antioxidant activity [34], it may be important to consider these factors to perform an in-depth analysis. Lastly, our analysis did not consider physical activity as a confounding factor, although it has been shown to influence blood lipid profiles [35,36]. Additional confounding factors, such as physical activity, may need to be considered for further analysis.…”

Section: Discussionmentioning

confidence: 99%

Effects of Coffee Intake on Dyslipidemia Risk According to Genetic Variants in the ADORA Gene Family among Korean Adults

et al. 2020

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Current evidence on the effects of coffee intake on cardiovascular diseases is not consistent, in part contributed by the genetic variability of the study subjects. While adenosine receptors (ADORAs) are involved in caffeine signaling, it remains unknown how genetic variations at the ADORA loci correlate the coffee intake with cardiovascular diseases. The present study examined the associations of coffee intake with dyslipidemia risk depending on genetic variants in the ADORA gene family. The study involved a population-based cohort of 4898 Korean subjects. Consumption of more than or equal to a cup of coffee per day was associated with lower dyslipidemia risk in females carrying the ADORA2B minor allele rs2779212 (OR: 0.645, 95% CI: 0.506–0.823), but not in those with the major allele. At the ADORA2A locus, male subjects with the minor allele of rs5760423 showed instead an increased risk of dyslipidemia when consuming more than or equal to a cup of coffee per day (OR: 1.352, 95% CI: 1.014–1.802). The effect of coffee intake on dyslipidemia risk differs depending on genetic variants at the ADORA loci in a sex-specific manner. Our study suggests that a dietary guideline for coffee intake in the prevention and management of dyslipidemia ought to consider ADORA-related biomarkers carefully.

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“…Low-density lipoprotein is a well-known cardiovascular risk factors, and it is also known that sedentary lifestyle is closely associated with poor low-density lipoprotein levels. Although physical performance evaluated with oxygen uptake were inversely correlated with low-density lipoprotein levels of professional athletes [32] and non-athlete subjects [33], the relationship between myocardial performance and lipid parameters was not adequately studied before. The present study demonstrates a significant association between myocardial performance index and low-density lipoprotein levels in elite athletes.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Performance in Elite Athletes: The Role of Homocysteine, Iron, and Lipids

Duyuler

2019

Med Sci Monit

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Background The myocardial performance index (MPI) is a comprehensive measure of global systolic and diastolic function of the ventricle, and it has an inverse correlation with maximal oxygen consumption. In this study, the potential association between left ventricle MPI and biochemical biomarkers (including iron, homocysteine, and lipids) in elite athletes was investigated. Material/Methods This cross-sectional observational study consisted of 80 young male elite soccer and basketball players (age: 18–34 years) examined for a seasonal medical check-up. Cardiological examinations and transthoracic echocardiography of these athletes were performed and blood samples were analyzed according to standard laboratory protocols. Tissue Doppler recording was acquired from the mitral annulus using apical 4-chamber view and then the tissue Doppler-derived MPI was computed. Results Athletes were separated into 2 groups based on MPI values (MPI ≤0.40 and MPI >0.40), and baseline demographic, clinical, and biochemical variables of the study participants were compared between these 2 groups. Serum triglyceride, high-density lipoprotein, total cholesterol, homocysteine levels, and iron parameters did not significantly differ between groups, while low-density lipoprotein level was significantly lower in the MPI ≤0.40 group (103.8±26.0 mg/dl vs. 116.8±30.2 mg/dl; p=0.043). Correlation analysis and multivariate linear regression analysis demonstrated a significant association between low-density lipoprotein and MPI. Conclusions In this study, various biochemical markers were evaluated for possible association with left ventricle MPI as a surrogate of cardiac performance. Among these biomarkers, only low-density lipoprotein was significantly associated with MPI in elite athletes.

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Relationship between Cardiorespiratory Fitness and Non-High-Density Lipoprotein Cholesterol: A Cohort Study

Cited by 15 publications

References 33 publications

Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study

Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study

Effects of Coffee Intake on Dyslipidemia Risk According to Genetic Variants in the ADORA Gene Family among Korean Adults

Myocardial Performance in Elite Athletes: The Role of Homocysteine, Iron, and Lipids

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