Relationship between butyrylcholinesterase activity and liver injury in mice acute infected with Toxoplasma gondii

Silva, Aleksandro S. Da; Tonin, Alexandre Alberto; Thorstenberg, Maria Luiza; Leal, Daniela Bitencourt Rosa; Fighera, Rafael A.; Flores, Mariana M.; França, Raqueli Teresinha; Camillo, Giovana; Vogel, Fernanda Silveira Flores; Rue, Mario de la; Lopes, Sonia T.A.

doi:10.1016/j.prp.2012.10.007

Cited by 18 publications

(17 citation statements)

References 31 publications

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“…Our results showed a statistically reduced BChE activity in subgroup B2 (animals with more advanced and severe grade of mammary carcinoma), suggesting a worse prognosis, corroborating with Rao et al [59]. Other researchers obtained similar results and reported that since BChE is synthesized in the liver parenchyma, a decrease in liver function may result in a reduction in the amount of this enzyme [60].…”

Section: Discussionsupporting

confidence: 90%

Oxidative stress and inflammatory response biomarkers in dogs with mammary carcinoma

Machado

Crivellenti

Bottari

et al. 2015

Pathology - Research and Practice

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Section: Discussionsupporting

confidence: 90%

Oxidative stress and inflammatory response biomarkers in dogs with mammary carcinoma

Machado

Crivellenti

Bottari

et al. 2015

Pathology - Research and Practice

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“…Despite some disadvantages, measurements of TAC and TOS concentrations are a practical way to identify the oxidative status of an organism (13,32). One of the products formed during the oxidative damage-induced decomposition of polyunsaturated fatty acid is MDA (8). The present study found significant increases in TOS levels and MDA concentrations in both monoand co-infected dogs.…”

Section: Co-infected (N = 23)supporting

confidence: 47%

“…Oxidative stress and increased lipid peroxidation has been shown in dogs with CME because of free-radical activity and an impaired antioxidant system (2,8,36). Paraoxonase (PON-1) and arylesterase (ARE) are esterase enzymes with antioxidant properties in a complementary structure.…”

Section: Praca Oryginalnamentioning

confidence: 99%

Oxidative status and lipid profile in mono- and co-infection with canine monocytic ehrlichiosis

Gültekin

Ural

Paşa

et al. 2017

Medycyna Weterynaryjna

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SummaryVector-borne diseases in dogs are a major health problem of zoonotic importance. Canine monocytic ehrlichiosis (CME) is one of the most common vector-borne infections in dogs. Co-infections with vectorborne diseases are reported to cause more severe pathological effects than mono-infections. The current study investigates the effects of mono-and co-infections with CME on oxidative status and lipid profiles in dogs. Dogs with vector-borne diseases were divided into two groups, mono-infected (n = 22) and co-infected (n = 23) with CME, and compared to a healthy group (n = 20). Double and triple co-infections with other vector-borne diseases included A. phagocytophilum, L. infantum, and D. immitis. The serum lipid profile (high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, and triglycerides) and the total and individual markers of oxidative status (total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), paraoxonase (PON-1), and arylesterase (ARE)) were evaluated. Significant decreases in PON-1 and ARE enzyme activities and HDL concentration, as well as increases in TOS level, MDA, LDL, and triglyceride concentrations were determined in both mono-and co-infected groups compared to the healthy control group. No significant differences between the groups were found in the TAC level or cholesterol concentration. In conclusion, alterations in lipid profile and increase in oxidative stress were observed in dogs with CME compared to the healthy control group, however, no significant differences were detected between mono-and co-infected dogs.

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“…Therefore, the enzyme BChE seems not to be involved in immune responses during acute toxoplasmosis in rats, unlike what happened with AChE. However, when the activity of BChE was evaluated in serum and liver of mice infected with T. gondii (an experimental model highly susceptible to the parasite), a reduction in this enzymatic activity was observed, associated with liver lesions, the major organ responsible for BChE synthesis [25]. Therefore, we believe that the difference between the studies is co-related to the experimental model used, leading to the conclusion that alteration in the levels of this enzyme is much more related to the liver injury than immune responses.…”

Section: Discussionmentioning

confidence: 99%

Influence of Toxoplasma gondii Acute Infection on Cholinesterase Activities of Wistar Rats

et al. 2013

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Several studies have shown the mechanisms and importance of immune responses against Toxoplasma gondii infection and the notable role of cholinesterases in inflammatory reactions. However, the association between those factors has not yet been investigated. Therefore, the aim of this study was to evaluate the acetylcholinesterase (AChE) activity in blood and lymphocytes and the activity of butyrylcholinesterase (BChE) in serum of rats experimentally infected with T. gondii during the acute phase of infection. For that, an in vivo study was performed with evaluations of AChE and BChE activities on days 5 and 10 post-infection (PI). The activity of AChE in blood was increased on day 5 PI, while in lymphocytes its activity was enhanced on days 5 and 10 PI (P<0.05). No significant difference was observed between groups regarding to the activity of BChE in serum. A positive (P<0.01) correlation was observed between AChE activity and number of lymphocytes. The role of AChE as an inflammatory marker is well known in different pathologies; thus, our results lead to the hypothesis that AChE has an important role in modulation of early immune responses against T. gondii infection.

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Relationship between butyrylcholinesterase activity and liver injury in mice acute infected with Toxoplasma gondii

Cited by 18 publications

References 31 publications

Oxidative stress and inflammatory response biomarkers in dogs with mammary carcinoma

Oxidative stress and inflammatory response biomarkers in dogs with mammary carcinoma

Oxidative status and lipid profile in mono- and co-infection with canine monocytic ehrlichiosis

Influence of Toxoplasma gondii Acute Infection on Cholinesterase Activities of Wistar Rats

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