Relationship between brachial-ankle pulse wave velocity and cardiovascular risk factors of the metabolic syndrome

Choi, Kyung Mook; Lee, K.W.; Seo, Jae Hyun; Oh, Jung-Eun; Kim, S.G.; Kim, N.H.; Choi, Dong-Hwan; Baik, Sei Hyun

doi:10.1016/j.diabres.2004.02.014

Cited by 65 publications

(68 citation statements)

References 20 publications

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“…[24][25][26] This could potentially be explained by the observations that women with the MetS had stiffer arteries, 7,11,27 greater left ventricular mass and greater impairment of left ventricular function, 51,52 as compared with their male counterparts. In our study, however, no clear difference existed between men and women with regard to arterial stiffness, despite a single significant interaction term between the MetS and sex for the femoral compliance coefficient.…”

Section: Discussionmentioning

confidence: 99%

“…7,[21][22][23] Finally, several studies 13,[24][25][26] suggest that the association with CVD in the MetS may be stronger in women than in men, thus raising the question whether the impact of the MetS on arterial stiffness is also stronger in women than in men. 7,11,27 In view of these considerations, the purpose of this study was: (1) to examine in a population-based cohort of elderly individuals the association(s) between the MetS and arterial stiffness of both elastic and muscular arteries; (2) to examine whether any such associations were mediated by low-grade inflammation, IR or ED; and (3) to examine whether any association between the MetS and arterial stiffness is stronger in women than in men.…”

Section: Introductionmentioning

confidence: 99%

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The metabolic syndrome in elderly individuals is associated with greater muscular, but not elastic arterial stiffness, independent of low-grade inflammation, endothelial dysfunction or insulin resistance—The Hoorn Study

et al. 2009

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The metabolic syndrome (MetS) increases cardiovascular disease (CVD) risk. How MetS increases CVD risk is incompletely understood, but increasing arterial stiffness is one candidate link, which in turn could be explained by (low-grade) inflammation, endothelial dysfunction (ED) or insulin resistance (IR). However, MetSrelated increases in stiffness may not be uniformly distributed over muscular and elastic arteries. Therefore, the purpose of this study was to determine: (1) the associations between the MetS, and muscular and elastic arterial stiffness, and (2) whether any such associations could be explained by inflammation, ED or IR. These questions were addressed in the Hoorn Study. MetS was defined according to the NCEP (National Cholesterol Education Program) criteria. Arterial stiffness was determined by ultrasound, tonometry and echocardiography. Inflammation, ED and IR were estimated by C-reactive protein, flow-mediated vasodilation and the homoeostatic model for the assessment of IR, respectively. The results showed that MetS was associated with both femoral and brachial arterial stiffness, significantly so for the distensibility coefficients and for the femoral compliance coefficient. In the carotid artery and aorta, no particular pattern emerged. Additional adjustment for either inflammation, ED or IR did not materially alter the results. The results therefore indicate that muscular arteries may stiffen preferentially over elastic arteries and that distensibility is affected to a greater extent than compliance, thus maintaining volume compliance over vessel wall stiffening. Additionally, the increase in stiffness was not explained by inflammation, ED or IR and suggests that stiffening of the muscular arteries in MetS may not be the consequence of these phenomena.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The metabolic syndrome in elderly individuals is associated with greater muscular, but not elastic arterial stiffness, independent of low-grade inflammation, endothelial dysfunction or insulin resistance—The Hoorn Study

et al. 2009

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“…Recently, Choi et al 13 demonstrated that baPWV significantly correlates with features of MetS in Korean women. This study was limited by its small size and inclusion of only women.…”

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confidence: 99%

The impact of pulse wave velocity in a Japanese population with metabolic syndrome

Hirashiki

Murohara

2009

Hypertens Res

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“…There have been many reports about the relationship between PWV and the development of atherosclerotic disease. Recent studies have demonstrated that PWV is not only a risk marker of cardiovascular disease, but also its prognostic predictor Altun et al 2004;Choi et al 2004;Fujiwara et al 2004;Mitchell et al 2004;Schmitt et al 2004;Stewart et al 2004;Woodside et al 2004).…”

mentioning

confidence: 99%

Comparison of Brachial-Ankle Pulse Wave Velocity in Japanese and Russians

Liu

Yambe

Zhang

et al. 2005

Tohoku J. Exp. Med.

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Pulse wave velocity (PWV) is a well-known indicator of arterial stiffness and a marker of the presence of vascular lesions. Cardiovascular mortality in Russia has become the highest in the world. The Japanese are enjoying long lives, and the mortality caused by cardiovascular diseases has thus far remained at lower levels than that in Russia. In this study, we focused on brachial-ankle pulse wave velocity (baPWV) obtained from normal human subjects in Russia as well as in Japan, and compared their respective cardiovascular risks. We evaluated baPWV in 337 Japanese and 138 Russian healthy subjects. The baPWV was recorded using a PWV diagnosis device. BaPWV was measured between 2 locations of the arterial tree. The baPWV in the Russian group was significantly higher than that obtained in the Japanese of two groups categorized by age (40-59 years and 60-years). Further, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure in the Russian group were significantly higher than those obtained in Japanese in three age groups (under 39 years, 40-59 years, and 60-years). Moreover, the baPWV indicated a positive correlation with age, BMI and SBP in both Japanese and Russians, although the increasing trend of the baPWV against age of the Russian group had a larger value than that of the Japanese. Therefore, we suggest that arterial stiffness might be promoted earlier in the Russian group, which might be the main cause of the increased cardiovascular risk in Russia.brachial-ankle pulse wave velocity; atherosclerosis; Japanese; Russians

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Relationship between brachial-ankle pulse wave velocity and cardiovascular risk factors of the metabolic syndrome

Cited by 65 publications

References 20 publications

The metabolic syndrome in elderly individuals is associated with greater muscular, but not elastic arterial stiffness, independent of low-grade inflammation, endothelial dysfunction or insulin resistance—The Hoorn Study

The metabolic syndrome in elderly individuals is associated with greater muscular, but not elastic arterial stiffness, independent of low-grade inflammation, endothelial dysfunction or insulin resistance—The Hoorn Study

The impact of pulse wave velocity in a Japanese population with metabolic syndrome

Comparison of Brachial-Ankle Pulse Wave Velocity in Japanese and Russians

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