The impact of pulse wave velocity in a Japanese population with metabolic syndrome

Hirashiki, Akihiro; Murohara, Toyoaki

doi:10.1038/hr.2009.182

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Pawiak et al (33) reported that IMT values were significantly decreased in dialysis patients who received EPO for more than 12 months compared to untreated patients. The mechanisms responsible for the high baPWV seem to be associated with increased left ventricular systolic pressure, decreased coronary flow due to decreased diastolic blood pressure as well as direct effects on the progression of atherosclerosis and left ventricular dysfunction (34). The result of the present study indicates that EPO reduced IMT and baPWV suggesting an anti-atherosclerotic effect in CKD patients.…”

Section: Discussionsupporting

confidence: 63%

Renovascular Protective Effects of Erythropoietin in Patients with Chronic Kidney Disease

et al. 2011

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Background/Aims Erythropoietin (EPO) has been widely used for the treatment of anemia in chronic kidney disease (CKD). A growing body of evidence indicates that the therapeutic benefits of EPO could extend beyond the improvement of anemia. The aim of the present study was to determine whether EPO affects renovascular and oxidative stress biomarkers in pre-dialysis CKD patients with anemia. Methods The study was a single-arm prospective study. Fifteen CKD patients (9 males and 6 females, mean age 63 years) with anemia (mean Hb: 8.1 g/dL) were treated with recombinant human EPO; 12,000 U administered subcutaneously once every 2 weeks. Various parameters were measured before and 6 months after treatment. These included serum hemoglobin (Hb), creatinine, estimated glomerular filtration rate (eGFR), proteinuria, urinary liver-type fatty acid binding protein (L-FABP -a biomarker of renal injury), urinary 8-hydroxydeoxyguanosine (8-OHdG -a marker of oxidative stress), serum asymmetrical dimethylarginine (ADMA), carotid artery intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) as vascular markers and plasma brain natriuretic peptide (BNP) levels and left ventricular ejection fraction (LVEF) as cardiac function markers and cardio-thoracic ratio (CTR) and inferior vena cava dimension (IVCS) as extra fluid retention markers. Results After 6 months, serum Hb was significantly increased (p<0.001) and urinary levels of protein, L-FABP and 8-OHdG, carotid IMT, baPWV, plasma BNP and serum ADMA levels were significantly decreased (p<0.001). Serum creatinine, eGFR, LVEF, CTR and IVCS showed little difference throughout the experimental period. Conclusion These data suggest that recombinant human EPO may ameliorate renal injury, oxidative stress and progression of atherosclerosis in addition to improving anemia in CKD patients.

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Section: Discussionsupporting

confidence: 63%

Renovascular Protective Effects of Erythropoietin in Patients with Chronic Kidney Disease

et al. 2011

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“…Studies examining the association between MetS and PWV have consistently shown that increased PWV in subjects with MetS or with larger number of MetS components 10-14. These suggest that the arterial stiffness in the MetS may be due to the subtle metabolic abnormalities, which develop gradually with aging.…”

Section: Introductionmentioning

confidence: 99%

Age- and Gender Dependent Association between Components of Metabolic Syndrome and Subclinical Arterial Stiffness in a Chinese Population

Weng¹,

Yuan²,

Tang³

et al. 2012

Int. J. Med. Sci.

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Background: The aim of this study was to estimate the relationship between arterial stiffness and components of metabolic syndrome (MetS) in different age- and gender groups.Methods: A total of 12,900 Chinese adults aged 20-79 years were recruited and stratified on the basis of gender and age. All participants underwent the measurement of waist circumference, blood pressure (BP), brachial-ankle pulse wave velocity (baPWV; an indicator of arterial stiffness), and blood chemistry. Multiple linear regression analysis was performed to evaluate the relationship between baPWV and above variables, to determine the relative influence of each component of MetS on baPWV.Results: The prevalence of metabolic disorders except for low high-density lipoprotein cholesterol (HDL-C) was much higher in men than in women. All participants with MetS or any component of MetS except for low HDL-C had higher baPWV. BP was positively correlated with baPWV in all groups, while HDL-C was not correlated with baPWV in any groups. In addition, fasting glucose was related to baPWV in middle-aged adults and the elderly. Waist circumference had a positive association with baPWV in middle-aged adults and young men, triglyceride levels showed a significant correlation with baPWV in middle-aged women and young men. Of the MetS components, elevated BP was the strongest predictor of baPWV.Conclusion: The prevalence of metabolic disorders and the association between baPWV and metabolic variables are dependent on age and gender. Different components of MetS exert distinct impacts on the baPWV in different age- and gender groups, with BP being the strongest predictor. It is suggested that age and gender should be taken into accounted in the management of MetS aiming to reduce subsequent complications.

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The association of metabolic syndrome and its components with brachial-ankle pulse wave velocity in south China

Chen

Wang

Mai³

et al. 2015

Atherosclerosis

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The impact of pulse wave velocity in a Japanese population with metabolic syndrome

Cited by 4 publications

References 15 publications

Renovascular Protective Effects of Erythropoietin in Patients with Chronic Kidney Disease

Renovascular Protective Effects of Erythropoietin in Patients with Chronic Kidney Disease

Age- and Gender Dependent Association between Components of Metabolic Syndrome and Subclinical Arterial Stiffness in a Chinese Population

The association of metabolic syndrome and its components with brachial-ankle pulse wave velocity in south China

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