Relationship between body mass index and arterial stiffness in a health assessment Chinese population

Tang, Biwen; Luo, Fangxiu; Zhao, Jiehui; Ma, Jing; Tan, Isabella; Butlin, Mark; Avolio, Alberto; Zuo, Junli

doi:10.1097/md.0000000000018793

Cited by 40 publications

(42 citation statements)

References 30 publications

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“…Their results showed that patients with lower admission MAP (<79 mmHg) presented worse inhospital prognosis (15). Interestingly, obesity (BMI ≥ 25 kg/m 2 ) was significantly related to higher average SBP, DBP, and MAP (16,25,26). These observations indicated an inhibitive role of obesity in the progression of MI.…”

Section: Discussionmentioning

confidence: 98%

Explore the Protective Role of Obesity in the Progression of Myocardial Infarction

Zhao

Cao

Zhang

et al. 2021

Front. Cardiovasc. Med.

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Obesity has been shown as a risk factor to increase the incidence of myocardial infarction (MI). However, obesity has also been linked to the decreased mortality of acute MI with unknown mechanisms. Here, we firstly used large-scale literature data mining to identify obesity downstream targets and MI upstream regulators with polarity, based on which an obesity-MI regulatory network was constructed. Then, a gene set enrichment analysis was conducted to explore the functional profile of the genes involved in the obesity-MI regulatory networks. After that, a mega-analysis using MI RNA expression datasets was conducted to test the expression of obesity-specific genes in MI patients, followed by a shortest-path analysis to explore any potential gene-MI association. Our results suggested that obesity could inhibit 11 MI promoters, including NPPB, NPPA, IRS1, SMAD3, MIR155, ADRB1, AVP, MAPK14, MC3R, ROCK1, and COL3A1, which were mainly involved in blood pressure-related pathways. Our study suggested that obesity could influence MI progression by driving multiple genes associated with blood pressure regulation. Moreover, PTH could be a novel obesity driven gene associated with the pathogenesis of MI, which needs further validation.

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Section: Discussionmentioning

confidence: 98%

Explore the Protective Role of Obesity in the Progression of Myocardial Infarction

Zhao

Cao

Zhang

et al. 2021

Front. Cardiovasc. Med.

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“…The data on the association between BMI and arterial stiffness parameters is, on the other hand, contradictory. In a study by Tang et al, the authors found a significant increase in ankle-brachial pulse wave velocity (abPWV) in patients with higher BMI values in studied cohort [ 40 ], while Rodriques et al failed to prove an independent association between cfPWV and BMI [ 41 ]. The authors Desamericq et al performed a study on 2.034 patients in which they found no relationship between cfPWV and BMI as well [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

The association between pulse wave analysis, carotid-femoral pulse wave velocity and peripheral arterial disease in patients with ischemic heart disease

Piko

Bevc

Hojs

et al. 2021

BMC Cardiovasc Disord

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Introduction Functional changes in peripheral arterial disease (PAD) could play a role in higher cardiovascular risk in these patients. Methods 123 patients who underwent elective coronary angiography were included. Ankle-brachial index (ABI) was measured and arterial stiffness parameters were derived with applanation tonometry. Results 6 patients (4.9%) had a previously known PAD (Rutherford grade I). Mean ABI was 1.04 ± 0.12, mean subendocardial viability ratio (SEVR) 166.6 ± 32.7% and mean carotid-femoral pulse wave velocity (cfPWV) 10.3 ± 2.4 m/s. Most of the patients (n = 81, 65.9%) had coronary artery disease (CAD). There was no difference in ABI among different degrees of CAD. Patients with zero- and three-vessel CAD had significantly lower values of SEVR, compared to patients with one- and two-vessel CAD (159.5 ± 32.9%/158.1 ± 31.5% vs 181.0 ± 35.2%/166.8 ± 27.8%; p = 0.048). No significant difference was observed in cfPWV values. Spearman's correlation test showed an important correlation between ABI and SEVR (r = 0.196; p = 0.037) and between ABI and cfPWV (r = − 0.320; p ≤ 0.001). Multiple regression analysis confirmed an association between cfPWV and ABI (β = − 0.210; p = 0.003), cfPWV and mean arterial pressure (β = 0.064; p < 0.001), cfPWV and age (β = 0.113; p < 0.001) and between cfPWV and body mass index (BMI (β = − 0.195; p = 0.028), but not with arterial hypertension, dyslipidemia, diabetes mellitus or smoking status. SEVR was not statistically significantly associated with ABI using the same multiple regression model. Conclusion Reduced ABI was associated with increased cfPWV, but not with advanced CAD or decreased SEVR.

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“…7) The possible mechanism underlying the differential effect of shortterm exposure to PM10 on high PWV in non-obese subjects may be as follows. Previously, Tang et al 20) suggested that obese individuals have greater nutritional reserves and can therefore cope better with acute stressful events and increased metabolic demands due to the benefi- sure and underestimate the association in long-term exposure-related adverse health effects. Finally, because we did not have information regarding the timing of the activities of each patient, we could not ascertain the exact location and timing of exposure to PM10, which could lead to a bias if the PM10 levels between the patient's workplace and residence differ.…”

Section: Discussionmentioning

confidence: 99%

“…The possible mechanism underlying the differential effect of short-term exposure to PM 10 on high PWV in non-obese subjects may be as follows. Previously, Tang et al [ 20 ] suggested that obese individuals have greater nutritional reserves and can therefore cope better with acute stressful events and increased metabolic demands due to the beneficial effect of adipose tissue induced by beneficial hormones and cytokines. In our study, relatively healthy, non-obese individuals showed significantly lower body fat percentage based on our data (body fat % of obese versus non-obese=30.4% versus 25.9%), which may be a possible mechanism by which non-obese individuals have difficulty coping with short-term exposure to PM 10 , resulting in high PWV.…”

Section: Discussionmentioning

confidence: 99%

Short- and Long-Term Exposure to Particulate Matter and Pulse Wave Velocity

et al. 2021

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Background: In hemodialysis patients, brachial-ankle pulse wave velocity (baPWV) levels are affected by particulate matter with an aerodynamic diameter of 10 μm or less (PM10). We conducted this study to determine whether there is an association between short- and long-term PM10 exposure and baPWV in apparently healthy adults aged 40 years and older.Methods: A total of 1,628 subjects who underwent health examinations between 2006 and 2009 were included in the study. On the basis of the day of medical screening, the 1–3-day and 365-day moving averages of PM10 concentrations were used to evaluate the association between short- and long-term exposure to PM10 and high baPWV (≥the third quartile of baPWV, 1,534 cm/s) using logistic regression models. Additional subgroup analyses were conducted according to age, sex, obesity (body mass index ≥25.0 kg/m2), and comorbidities such as metabolic syndrome.Results: No statistically significant associations were identified between short-term and long-term exposure to PM10 and baPWV in any of the subjects and subgroups. A 10-μg/m3 increase in the 2-day moving average of PM10 exposure was marginally associated with high baPWV in non-obese subjects (odds ratio, 1.059; P=0.058). This association in non-obese subjects was significantly different from that in obese subjects (P=0.038).Conclusion: This study did not show statistically significant associations between short-term and long-term exposure to PM10 and baPWV in apparently healthy subjects. With short-term exposure to PM10, non-obese subjects showed a marginally unfavorable association with baPWV. Further studies are necessary to validate and elucidate the mechanism underlying the effect of PM10 on baPWV.

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Relationship between body mass index and arterial stiffness in a health assessment Chinese population

Cited by 40 publications

References 30 publications

Explore the Protective Role of Obesity in the Progression of Myocardial Infarction

Explore the Protective Role of Obesity in the Progression of Myocardial Infarction

The association between pulse wave analysis, carotid-femoral pulse wave velocity and peripheral arterial disease in patients with ischemic heart disease

Short- and Long-Term Exposure to Particulate Matter and Pulse Wave Velocity

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