The association between pulse wave analysis, carotid-femoral pulse wave velocity and peripheral arterial disease in patients with ischemic heart disease

Abstract

Introduction Functional changes in peripheral arterial disease (PAD) could play a role in higher cardiovascular risk in these patients. Methods 123 patients who underwent elective coronary angiography were included. Ankle-brachial index (ABI) was measured and arterial stiffness parameters were derived with applanation tonometry. Results 6 patients (4.9%) had a previously known PAD (Rutherford grade I). Mean ABI was 1.04 ± 0.12, mean subendocardial viability ratio (SEVR) 166.6 ± 32.7% and mean carotid-femoral pulse wave velocity (cfPWV) 10.3 ± 2.4 m/s. Most of the patients (n = 81, 65.9%) had coronary artery disease (CAD). There was no difference in ABI among different degrees of CAD. Patients with zero- and three-vessel CAD had significantly lower values of SEVR, compared to patients with one- and two-vessel CAD (159.5 ± 32.9%/158.1 ± 31.5% vs 181.0 ± 35.2%/166.8 ± 27.8%; p = 0.048). No significant difference was observed in cfPWV values. Spearman's correlation test showed an important correlation between ABI and SEVR (r = 0.196; p = 0.037) and between ABI and cfPWV (r = − 0.320; p ≤ 0.001). Multiple regression analysis confirmed an association between cfPWV and ABI (β = − 0.210; p = 0.003), cfPWV and mean arterial pressure (β = 0.064; p < 0.001), cfPWV and age (β = 0.113; p < 0.001) and between cfPWV and body mass index (BMI (β = − 0.195; p = 0.028), but not with arterial hypertension, dyslipidemia, diabetes mellitus or smoking status. SEVR was not statistically significantly associated with ABI using the same multiple regression model. Conclusion Reduced ABI was associated with increased cfPWV, but not with advanced CAD or decreased SEVR.

Long-Term Prognosis after Coronary Artery Bypass Grafting: The Impact of Arterial Stiffness and Multifocal Atherosclerosis

“…Therefore, studies of this index in other countries and ethnic groups are extremely topical [ 7 ]. It can also be noted that an increase in arterial stiffness and the development of atherosclerosis of the arterial wall may reflect various pathophysiological processes [ 26 ], and there is evidence of an increase in prognostic value when jointly assessing arterial stiffness and the ankle-brachial index in myocardial infarction [ 11 ]. Therefore, it seems interesting to study the complex effect of these factors on the prognosis after CABG.…”

Changes in the subendocardial viability ratio in patients with atherosclerotic coronary heart disease

“…SEVR is a noninvasive method to assess myocardial perfusion and the prognostic value of CVD [36]. It is signi cantly low in patients with zero-and three-vessel CHDs [37]. In this study, it was lower in the high stenosis group than in the control and low stenosis groups classi ed according to the SYNTAX score.…”

Associations of Walking Activity With Hypertensive Mediated Organ Damage in Community-Dwelling Elderly Chinese: The Northern Shanghai Study

“…With regard to cardiac HMOD, left ventricular hypertrophy was defined as LVMI ≥ 115 g/m 2 (male) or LVMI ≥ 95 g/m 2 (female) ( 26 ), and LV diastolic dysfunction was defined as E/Ea ≥ 15, or 15 > E/Ea > 8 with any of the following: LAVI > 40 ml/m 2 or LVMI > 149 g/m 2 (male) or LVMI ≥ 122 g/m 2 (female) ( 27 ). Chronic kidney diseases (CCR <60 ml/min/1.73 m 2 ) and microalbuminuria (UACR > 30) represented renal HMOD ( 28 ), while vascular HMOD included the presence of arterial plaque, increased CIMT (CIMT > 900 μm), arterial stiffness (cf-PWV ≥ 12 m/s), and peripheral artery disease (ABI < 0.9) ( 16 , 17 , 29 ).…”