Relationship between blood viscosity and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Cecchi, Emanuele; Liotta, Agatina Alessandriello; Gori, Anna Maria; Valente, Serafina; Giglioli, Cristina; Lazzeri, Chiara; Sofi, Francesco; Gensini, Gian Franco; Abbate, Rosanna; Mannini, Lucia

doi:10.1016/j.ijcard.2008.01.039

Cited by 29 publications

(15 citation statements)

References 34 publications

(27 reference statements)

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“…It has thus been suggested that elevated RDW could be an indicator of altered red blood cell rheological properties that result in significant changes in the microcirculation with consequent sluggish flow and occlusion. In keeping with this, Cecchi et al demonstrated an association between blood viscosity and infarct size in patients with ST-segment elevation MI undergoing primary percutaneous coronary intervention 20. Furthermore, elevated RDW was shown to be an independent predictor of impaired coronary collateral circulation in patients with non-ST elevation MI21 as well as slow coronary flow 22.…”

Section: Discussionmentioning

confidence: 82%

Red blood cell distribution width and myocardial scar burden in coronary artery disease

Magri¹,

Tian

Camilleri

et al. 2017

Postgraduate Medical Journal

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Section: Discussionmentioning

confidence: 82%

Red blood cell distribution width and myocardial scar burden in coronary artery disease

Magri¹,

Tian

Camilleri

et al. 2017

Postgraduate Medical Journal

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“…The alteration of the hemorheological properties was associated with the size of myocardial infarction [15] and adverse outcomes of critical care conditions [16]. In our literature search, we have found an association between elevated RDW and altered hemorheological features (for example, increased total blood viscosity [17], red blood cell agglutination and fragmentation [12,18]).…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Red Cell Distribution Width in Predicting All-Cause Long-Term Mortality after Non-ST-Elevation Myocardial Infarction

Azab¹,

Torbey²,

Hatoum³

et al. 2011

Cardiology

100

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Background: Red blood cell distribution width (RDW) is a strong predictor of adverse outcomes in patients with heart failure, stable coronary artery disease, stroke and acute myocardial infarction. The aim of our study was to explore the predictive value of RDW on all-cause mortality in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Method: This observational study includes 619 NSTEMI patients, discharged from Staten Island University Hospital between September 2004 and December 2006. Patients were divided into equal RDW tertiles and survival was evaluated in each tertile. Result: Patients in the highest RDW tertile (RDW >14) had higher in-patient (7 vs. 1%) and 4-year (30 vs. 7%) mortality rates compared to those in the lowest tertile (RDW <13) (Wilcoxon χ² = 34.64, p < 0.0001). After controlling for Global Registry of Acute Coronary Events risk profile scores and other confounding variables, the RDW adjusted hazard ratio for 4-year all-cause mortality increased by 1.10 for each one unit increase in RDW (confidence interval 1.004–1.213, p = 0.042). Conclusion: RDW is an independent predictor of all-cause long-term mortality in NSTEMI patients. Further studies are needed to clarify the mechanisms of this association between RDW and adverse outcomes in patients with coronary artery disease.

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“…As reported by Cecchi et al [8], alterations of hemorheological variables such as elevated low shear viscosity and reduced RBC deformability could produce the decreased final TIMI flow after PCI, which in turn was associated with an increased infarct size. Claeys et al [12] also reported that despite the successful recanalization of an occluded infarct artery manifested by the achievement of good TIMI flow, the reperfusion at the level of the microcirculation remained impaired due to a process of microvascular reperfusion injury.…”

Section: Discussionmentioning

confidence: 65%

“…Several researchers [8,13,21] who utilized blood samples from anti-cubital veins also found elevated WBVs in AMI patients. The contribution of elevated WBV to myocardial injury has been attributed to increased propensity for red cell aggregation.…”

Section: Discussionmentioning

confidence: 99%

Elevated coronary whole blood viscosity in acute coronary syndrome patients

Lee

Jung

et al. 2013

Clinical Hemorheology and Microcirculation

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OBJECTIVES: As most clinical studies measure whole blood viscosity (WBV) from peripheral samples, potential differences in WBV obtained from the coronary arteries are often ignored. This study investigated differences in WBV measured from coronary artery specimens in patients with and without acute coronary syndrome (ACS). METHODS AND RESULTS: Consecutive patients with chest pain who underwent diagnostic coronary angiography were divided into two groups [non-ACS (n = 16), ACS (n = 22)]. The ACS group consisted of unstable angina (n = 13) and acute myocardial infarction (n = 9) patients. Two blood samples were obtained from each patient at the both coronary artery ostia prior to coronary angiography. Low-shear and high-shear blood viscosities (BVs) were measured at shear rates of 1 and 300 s −1 , respectively, by a scanning capillary tube viscometer (Bio-Visco Inc., South Korea). Both low-shear and high-shear BVs obtained from peripheral, left and right coronary arteries were not different in both groups. Mean coronary low-shear WBV values obtained in ACS group were 29.2% higher than those in non-ACS group (295.3 ± 87.2 mP vs. 228.5 ± 69.2 mP, p = 0.016). Mean coronary high-shear WBV values obtained in ACS group were 15.6% higher than those in non-ACS group (42.9 ± 10.0 mP vs. 37.1 ± 4.6 mP, p = 0.036). CONCLUSIONS: Direct measurement of WBV from the coronary artery showed no differences with peripheral samples. Future larger studies are needed to clarify our results.

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Relationship between blood viscosity and infarct size in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Cited by 29 publications

References 34 publications

Red blood cell distribution width and myocardial scar burden in coronary artery disease

Red blood cell distribution width and myocardial scar burden in coronary artery disease

Usefulness of Red Cell Distribution Width in Predicting All-Cause Long-Term Mortality after Non-ST-Elevation Myocardial Infarction

Elevated coronary whole blood viscosity in acute coronary syndrome patients

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