Usefulness of Red Cell Distribution Width in Predicting All-Cause Long-Term Mortality after Non-ST-Elevation Myocardial Infarction

Abstract

Background: Red blood cell distribution width (RDW) is a strong predictor of adverse outcomes in patients with heart failure, stable coronary artery disease, stroke and acute myocardial infarction. The aim of our study was to explore the predictive value of RDW on all-cause mortality in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Method: This observational study includes 619 NSTEMI patients, discharged from Staten Island University Hospital between September 2004 and December 2006. Patients were divided into equal RDW tertiles and survival was evaluated in each tertile. Result: Patients in the highest RDW tertile (RDW >14) had higher in-patient (7 vs. 1%) and 4-year (30 vs. 7%) mortality rates compared to those in the lowest tertile (RDW <13) (Wilcoxon χ² = 34.64, p < 0.0001). After controlling for Global Registry of Acute Coronary Events risk profile scores and other confounding variables, the RDW adjusted hazard ratio for 4-year all-cause mortality increased by 1.10 for each one unit increase in RDW (confidence interval 1.004–1.213, p = 0.042). Conclusion: RDW is an independent predictor of all-cause long-term mortality in NSTEMI patients. Further studies are needed to clarify the mechanisms of this association between RDW and adverse outcomes in patients with coronary artery disease.

Red cell distribution width is associated with acute myocardial infarction in young patients

“…Investigators showed that an increased RDW was independently associated with in hospital and long-term all-cause mortality and coronary events in STEMI, non-ST elevation MI and unselected population of male patients referred for coronary angiography [2,25,26]. Also in other studies a high admission RDW was independently associated with worse reperfusion and increased risk in-hospital and long-term cardiovascular mortality in patients with STEMI undergoing primary percutaneous intervention [27].…”

Medical significance of simultaneous application of red blood cell distribution width (RDW) and neopterin as diagnostic/prognostic biomarkers in clinical practice

“…In conclusion, we recommended the results of our study be applied in medical practice in order to determine their clinical usefulness to optimize the treatment of some vascular/cardiovascular complications such as hypoxemia, major ischemic syndrome, circulatory disturbances, hypertension, cardiac arrythmia, acute myocardial infarction (AMI), etc. The prognostic value of RWD, as stated in our above-mentioned previous study has been recognized and this parameter was used for further studies by mainly cardiologists [6][7][8][9][10][11] (Table 1).…”

Evaluation of mean platelet volume, neutrophil lymphocyte ratio, platelet lymphocyte ratio and red cell distribution width in panic disorder

“…Aneminin ayırıcı tanısında kullanılmasının yanında, genel popülasyonda akut kalp yetmezliği, pulmoner emboli, akut myokard infarktüsü (AMI), periferik arter hastalığı ve akut böbrek yetmezliğinde mortalite göstergesi olarak kullanıla-bileceğini gösteren çalışmalar da vardır. 12,13 Alzheimer tipi bunamalı hastalarda yapılan bir çalışmada, EDG değeri anlamlı olarak daha yüksek bulunmuştur. 14 PB hastalarında yapı-lan bir başka çalışmada, EDG değerinin kontrol grubuna göre daha yüksek saptandığı bildirilmiştir.…”