Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease

Eltboli, Osama; Mistry, Vijay; Barker, Bethan; Brightling, Christopher E.

doi:10.1111/resp.12475

Cited by 75 publications

(54 citation statements)

References 7 publications

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“…Another important aspect that also reflects the discrepancies is whether the BEC is a good reference of the eosinophils in the airway. Thus, in a study comparing the BEC with the eosinophilia in the bronchial submucosa, a good correlation is obtained between both determinations in patients with COPD . Another study conducted in Australia comparing the BEC with the eosinophils in sputum also obtained a good correlation between both compartments .…”

Section: Discussionmentioning

confidence: 84%

“…Thus, in a study comparing the BEC with the eosinophilia in the bronchial submucosa, a good correlation is obtained between both determinations in patients with COPD. 33 Another study conducted in Australia comparing the BEC with the eosinophils in sputum also obtained a good correlation between both compartments. 24 On analysing a population with COPD that presents with exacerbations, the BEC would be the better indicator of eosinophilia in sputum.…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 81%

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Blood eosinophils could be useful as a biomarker in chronic obstructive pulmonary disease exacerbations

Barcala

San-Jose²,

Nieto‐Fontarigo

et al. 2019

Int J Clin Pract

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Summary IntroductionThe aim of analysing the usefulness of the blood eosinophil count (BEC) as a prognostic marker in exacerbations of patients with Chronic Obstructive Pulmonary Disease (COPD), evaluating its relationship with hospital mortality, the length of stay and the early and late re‐admissions. Materials and MethodsWe have carried out a retrospective study including all patients who required hospital admission from 1 January 2008 to 31 December 2009, with a diagnosis on hospital discharge of COPD exacerbation. These patients were classified using three cut‐off points of BEC: less than 200 vs ≥ 200/µL, less than 300 vs ≥ 300/µL and less than 400 vs ≥ 400/µL. ResultsThere were a total of 1626 hospital admissions during the study period with the diagnosis of exacerbation of COPD. In this study we have included 358 patients. The probability of any late re‐admission increased with a BEC ≥ 300/µL (odds ratio: 1.684) and for those with a BEC ≥ 400/µL (odds ratio: 2.068). The BEC does not appear to be related to hospital mortality or the probability of early re‐admission after an exacerbation of COPD. ConclusionsIn our study an elevated BEC is associated with a higher incidence of late hospital readmissions in COPD exacerbations.

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Section: Discussionmentioning

confidence: 84%

Section: Ta B L E 1 (Continued)mentioning

confidence: 81%

Blood eosinophils could be useful as a biomarker in chronic obstructive pulmonary disease exacerbations

Barcala

San-Jose²,

Nieto‐Fontarigo

et al. 2019

Int J Clin Pract

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show abstract

“…Eltboli and colleagues [24] reported that there is a strong correlation between peripheral blood and bronchial eosinophils and reticular basement membrane thickening and suggested that the peripheral blood eosinophil count does identify COPD subjects with a greater tissue eosinophilia. A recent study documented that airway wall thickness is independently associated with a stronger decline in lung function [25].…”

Section: Discussionmentioning

confidence: 99%

The Time Course of Pulmonary Function Tests in COPD Patients with Different Levels of Blood Eosinophils

Rogliani

Puxeddu

Ciaprini

et al. 2016

BioMed Research International

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Only very few studies have investigated the influence of eosinophils on the functional progression of COPD. We aimed at retrospectively analyzing the trend of pulmonary function tests over time in patients with COPD according to two baseline blood eosinophil cell count strata (<2% [EOS−] and ≥2% [EOS+]). We used the last 9-year data present in the database of our outpatient clinic and selected only those who had two blood counts that would guarantee the stability of the value of eosinophils and serial spirometry for 4 consecutive years. The analysis of the time course of the spirometric variables analysed showed differences in FEV1 and FVC decline between the subjects of the EOS− group and those of the EOS+ group. The integrated evaluation of our results suggests that the different level of blood eosinophils in the two groups may have influenced independently the time course of the pulmonary function tests and identify two subgroups of subjects with specific disease characteristics: the hyperinflator and the rapid decliner, respectively.

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“…Although blood eosinophils are easy to measure in clinical practice, it is uncertain whether they closely reflect sputum or tissue eosinophilia. Increased blood eosinophils predict an increase in sputum eosinophils (>3%) in around 70% of patients but there is only a weak relationship between blood and sputum or bronchial eosinophils in COPD patients . One problem is that blood eosinophils counts are variable over time and even within the same day, so that it is important to make repeated measurements.…”

Section: Eosinophilic Copdmentioning

confidence: 99%

Inflammatory endotypes in COPD

Barnes

2019

Allergy

181

155

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Chronic obstructive pulmonary disease (COPD) is a major global health problem that is poorly treated by current therapies as it has proved difficult to treat the underlying inflammation, which is largely corticosteroid-resistant in most patients. Although rare genetic endotypes of COPD have been recognized, despite the clinical heterogeneity of COPD, it has proved difficult to identify distinct inflammatory endotypes.Most patients have increased neutrophils and macrophages in sputum, reflecting the increased secretion of neutrophil and monocyte chemotactic mediators in the lungs.However, some patients also have increased eosinophils in sputum and this may be reflected by increased blood eosinophils. Increased blood and sputum eosinophils are associated with more frequent exacerbations and predict a good response to corticosteroids in reducing and treating acute exacerbations. Eosinophilic COPD may represent an overlap with asthma but the mechanism of eosinophilia is uncertain as, although an increase in sputum IL-5 has been detected, anti-IL-5 therapies are not effective in preventing exacerbations. More research is needed to link inflammatory endotypes to clinical manifestations and outcomes in COPD and in particular to predict response to precision medicines. K E Y W O R D Sasthma-COPD overlap, eosinophil, exacerbations, interleukin-5, macrophage, neutrophil

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Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease

Cited by 75 publications

References 7 publications

Blood eosinophils could be useful as a biomarker in chronic obstructive pulmonary disease exacerbations

Blood eosinophils could be useful as a biomarker in chronic obstructive pulmonary disease exacerbations

The Time Course of Pulmonary Function Tests in COPD Patients with Different Levels of Blood Eosinophils

Inflammatory endotypes in COPD

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