The Time Course of Pulmonary Function Tests in COPD Patients with Different Levels of Blood Eosinophils

Rogliani, Paola; Puxeddu, Ermanno; Ciaprini, Chiara; Ora, Josuel; Onorato, Angelo; Pezzuto, Gabriella; Calzetta, Luigino; Cazzola, Mario

doi:10.1155/2016/4547953

Cited by 10 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Declines in FEV1, FEV1/FVC were the indicators of pulmonary obstructive abnormalities [21] . Decrease in pulmonary parameters especially FEV1 was the first measurable sign of the initiation of bronchitis and obstructive lung disease in smokers [22] which were shown in our study population an official report of the American Thoracic Society documented the relationship between occupational exposures and an increased risk in chronic cough, lower FEV1, and a lower FEV1/FVC [23] .…”

Section: Discussionsupporting

confidence: 79%

See 1 more Smart Citation

Evaluation of Pulmonary Capacity and Prevalence of Pulmonary Dysfunctions of Bell Metal Workers in Relation to their work Experience and Smoking Habit

Das¹,

Mahata²,

Dhara³

2017

Int. J. Life. Sci. Scienti. Res.

View full text Add to dashboard Cite

The bell metal works is the oldest cottage industries mainly clustered around the Bankura, Purulia and Medinipur (W) districts in West Bengal, India. The smelting, hammering, scraping and paddle rolling are the most predominant activities in their Bell Metal work process. During work, different types of metal fumes are sublimated to their working environment. The present study was to investigate the prevalence of pulmonary dysfunctions of these workers. 363 workers were randomly selected of them 263 were exposed and 100 were control workers. The prevalence of pulmonary symptoms was determined by a standardized questionnaire. Pulmonary indices viz. FVC%, FEV1%, FEF 25%-75% , FEV1/FVC%, MVV-Index and PEFR were measured by a digital spirometer and smoking frequency was determined by Nitti Index. Study results revealed that there were significant differences in height (p<0.05), weight and BMI (p<0.001) between the exposed and control groups. All pulmonary indices were significantly (p<0.05 or less) lower in exposures than controls. The prevalence of different pulmonary diseases viz., COPD (p<0.05), asthma (p<0.001), wheezing (p<0.01) and breathlessness (p<0.001) were significantly higher in exposures than that of the control. It was concluded that the exposures had reduced pulmonary capacity, which might be due to expose of different gases, fumes and other pulmonary irritants. The occurrences of pulmonary diseases were higher in bell metal workers than that of non-exposed workers. Smoking and work experience may be additive adverse effect on it.This alloy manufacturing, which is usually done at home in small and medium scales (SMSc) industries, is one of the oldest cottage industries in Nepal, China, Japan, Korea, Thailand and in India, including West Bengal state, from the ancient time [1] . It is an industry which had been handed over from generation to generation. The processes which were totally manual have not been mechanized till now. Tin and copper are scrap metal, smelted at an above 232°C and 1084°C respectively [2] by using coal and poured into sand casts of various shapes to prepare a bell ingot. During smelting and casting, different types of metal fumes (e.g. copper, tin, lead, silica etc) are sublimated to their working environment. Bell and silica, tin, coal dust may be released during fettling and polishing. Gases such as metal oxides, formaldehydes, PAHs CO, ozone, oxides of nitrogen, Sulpher [3] , acetylene and ARTICLE RESEARCHInt.

show abstract

Section: Discussionsupporting

confidence: 79%

“…Bell metal is an alloy consisting mainly of 78% copper (Cu) and 22% of tin (Sn) in78: 22. In addition it may contain metals such as lead (Pb), cadmium (Cd), silica (Si), zinc (Zn), iron (Fe), arsenic (As) etc which may be added intentionally to improve the quality of the alloy or may be present as impurities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Pulmonary Capacity and Prevalence of Pulmonary Dysfunctions of Bell Metal Workers in Relation to their work Experience and Smoking Habit

Das¹,

Mahata²,

Dhara³

2017

Int. J. Life. Sci. Scienti. Res.

View full text Add to dashboard Cite

show abstract

“… 35 Alternatively, the differences in decline of lung function associated with blood eosinophils < or ≥2% observed in the much smaller study over 9 years by Rogliani and colleagues should be examined in the larger SPIROMICS cohort longitudinally. 38 In summary, using the larger and comprehensive phenotypic characterization of the SPIROMICS cohort, we show that stratification by elevated sputum eosinophil inflammation identified a subgroup with more severe COPD, having decreased lung function, greater emphysema and air trapping, and greater COPD exacerbations. Peripheral blood eosinophils identified a subgroup with decreased lung function without other indices of more severe COPD, specifically exacerbations unless examined on the background of elevated sputum eosinophils.…”

Section: Discussionmentioning

confidence: 70%

Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort

Hastie

Martínez

Curtis

et al. 2017

The Lancet Respiratory Medicine

234

194

View full text Add to dashboard Cite

BackgroundEosinophils in blood and sputum in chronic obstructive pulmonary disease (COPD) have been associated with more frequent exacerbations, lower lung function, and corticosteroid responsiveness. We hypothesized increased eosinophils are associated with a severe COPD phenotype, including exacerbation frequency, and tested whether blood eosinophils reliably predict sputum eosinophils.MethodsComprehensive baseline data on SPIROMICS subjects, recruited for a range of COPD severity for smokers with ≥20 pack year history, included demographics, questionnaires, clinical assessments, quantitative computed tomography (QCT), blood and induced sputum.FindingsSignificantly, stratification by mean sputum eosinophils ≥1·25% (N=827) was associated with reduced FEV1 % predicted (differences: 10% pre-bronchodilator, 4·7% post-bronchodilator), QCT density measures for emphysema and air trapping, and exacerbations treated with corticosteroids (p=0·002). In contrast, stratification by mean blood eosinophils ≥200/µL (N=2499) showed that FEV1 % predicted was significant between low and high blood subgroups, but less than observed between sputum subgroups (blood eosinophil group differences: 4·2% pre-bronchodilator, 2·7% post-bronchodilator), slightly increased airway wall thickness (0·02 mm, p=0·032), greater symptoms (p=0·037), and wheezing (p=0·018), but no evidence of association with COPD exacerbations or other indices of severity. Blood eosinophils showed weak although significant association with sputum eosinophils (ROC AUC=0·64, p<0·001), but with a high false discovery rate (72%). Elevated sputum eosinophils, with or without blood eosinophils, were associated with lower lung function. Elevated blood eosinophils only in combination with elevated sputum eosinophils were associated with COPD exacerbations.InterpretationStratification of SPIROMICS subjects by blood eosinophils alone showed minimal clinical differences and no association with exacerbations, whereas stratification by sputum eosinophils was associated with larger phenotypic differences and COPD exacerbations. Importantly, increased blood eosinophils did not reliably predict airway eosinophils in induced sputum.

show abstract

“…23 The mortality of patients with COPD and high EOS count and asthma in the late-stage increases. Rogliani et al 24 retrospectively analyzed the trend of pulmonary function examination in patients with COPD over time, based on two baseline EOS count layers (<2% (EOS−) and ⩾2% (EOS+)). The results revealed a difference in the decrease of forced expiratory volume in 1 s (FEV1) and FVC between subjects in the EOS− group and EOS+ group.…”

Section: Selection Of a Sample And Boundary Value Of Eos Testmentioning

confidence: 99%

Review on the correlation between chronic obstructive pulmonary disease and eosinophil in peripheral blood

Liu

Cui

2021

Eur J Inflamm

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is an irreversible disease characterized by the limitation of continuous airflow. Eosinophil (EOS) in peripheral blood plays a key role in the acute exacerbation of COPD. Eosinophil-increased COPD has become an important variant of COPD and the focus of individualized treatment of COPD. Numerous studies have shown that an increased eosinophil count or an increased percentage in the peripheral blood closely correlates to the acute exacerbation and prognosis of COPD. Therefore, this study intends to review the progress of domestic and foreign research on the correlation between COPD and EOS.

show abstract

The Time Course of Pulmonary Function Tests in COPD Patients with Different Levels of Blood Eosinophils

Cited by 10 publications

References 29 publications

Evaluation of Pulmonary Capacity and Prevalence of Pulmonary Dysfunctions of Bell Metal Workers in Relation to their work Experience and Smoking Habit

Evaluation of Pulmonary Capacity and Prevalence of Pulmonary Dysfunctions of Bell Metal Workers in Relation to their work Experience and Smoking Habit

Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort

Review on the correlation between chronic obstructive pulmonary disease and eosinophil in peripheral blood

Contact Info

Product

Resources

About