Relationship Between Birth Weight and the Double Product in Childhood, Adolescence, and Adulthood (from the Bogalusa Heart Study)

Abstract

Low birth weight is associated with cardiovascular disease and its risk factors, including heart rate and blood pressure. Therefore, we examined the hypothesis that birth weight is related to blood pressure-heart rate product (double product, DP), an index of oxygen consumption and workload of the heart, at different ages. Resting heart rate, blood pressure, and birth weight data were available in 2,340 children (4–11 years), 1,621 adolescents (12–19 years), and 2,315 adults (20–52 years) from the Bogalusa Heart Study (total n=6,276). After adjustment for age, sex, race, and body mass index, gestational age-adjusted birth weight was inversely associated with DP, with per 100 gram decrease in birth weight associated with an increase of 12.8, 22.9, and 23.2 beats/min×mmHg in DP in children (p=0.016), adolescents (p=0.0007), and adults (p=0.0006), respectively. An amplifying trend of the association with age was observed in the total sample (P=0.002). In conclusion, birth weight is associated with increased DP beginning in childhood, which may partly mediate the association between low birth weight and increased cardiovascular risk later in life.

The effect of epididymal sperm cryopreservation on neonatal birthweight following PESA-ICSI

“…Birthweight is not only an important predictor of newborn survival, but also observationally associated with health risks and developmental issues in later life. An approximately 100 g decrease in birthweight is associated with subtle but signi cant changes in risk markers for diabetes and cardiovascular diseases [14,15]. For women, a 100 g decrease in birthweight may be associated with a 3% risk increase for hypertensive disorders of pregnancy in later life [16].…”

The sequence of prenatal growth restraint and postnatal catch‐up growth: normal heart but thicker intima‐media and more pre‐peritoneal fat in late infancy

“…Along these lines, the decrease in cardiomyocyte number observed in animal models after prenatal growth restraint seems to have an impact on cardiac functional reserve only in adulthood . Also, the association between birth weight and specific indices of cardiovascular performance experience an amplifying trend with age . Long‐term follow‐up is warranted to disclose whether the early vascular changes, namely, the increase in cIMT, may eventually compromise cardiac functioning.…”

Commentary: Fear of Massive Deportations in the United States: Social Implications on Deprived Pediatric Communities

“…Among non-Latina White mothers, no difference was observed. Studies indicate that infants with LBW have a higher likelihood of diabetes ( 4 , 5 ), heart disease ( 6 ), high blood pressure ( 4 , 7 ), and obesity ( 4 ) later in their lives, than infants of healthy birth weight.…”