Relationship between biomarker expression and allelic alteration in esophageal carcinoma

Abstract

The data suggest that overexpression of tissue biomarkers associated with allelic alterations may have potential prognostic implications with different behavior in esophagus cancer.

The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer

“…The survival analysis in their study showed that patients with TIMP-2-negative carcino- www.fhc.viamedica.pl ma had a significantly shorter disease-free survival in comparison with TIMP-2-positive tumors [56]. Moreover, these observations are in line with the study of Vegh et al, who found that the expression of TIMP-1 in ACE samples from EC patients with more than three positive lymph nodes was significantly lower than in subjects without lymph node involvement [57].…”

Biomarkers, Stem Cells and Esophageal Cancer

“…We found similar results in the concentration of MMP-1 in tumor vs. non-tumor areas in patients who had ESCC, but without being associated with the clinicopathological outcome (Vegh et al, 2007). On the other hand, we have observed that TIMP-1 expression in esophagus cancer showed higher values in tumor areas (Vegh et al, 2007). Interestingly, the same patients with lymph node negative showed higher values on TIMP-1 expression, whereas patients with more than three positive lymph nodes had lower values.…”

“…Moreover, MMP-1 was associated with poor clinical outcome in esophageal cancer in different studies (Etoh et al, 2000;Murray et al, 1998;Yamashita et al, 2001). We found similar results in the concentration of MMP-1 in tumor vs. non-tumor areas in patients who had ESCC, but without being associated with the clinicopathological outcome (Vegh et al, 2007). On the other hand, we have observed that TIMP-1 expression in esophagus cancer showed higher values in tumor areas (Vegh et al, 2007).…”

“…In esophagus cancer, we studied MMP-1 concentration in tumor and in non-tumor areas from the same patient with EA and observed a higher concentration in tumor areas (Vegh et al, 2007). Moreover, MMP-1 was associated with poor clinical outcome in esophageal cancer in different studies (Etoh et al, 2000;Murray et al, 1998;Yamashita et al, 2001).…”

“…Brief descriptions for it were focused on these tumor markers in different cancer types. The carcinoembrionary antigen CEA, is a glycoprotein involved in cell adhesion that was studied in lung carcinoma (Vegh et al, 2002) and colorectal carcinoma (Vegh et al, 2007). Cancer antigen 125 (CA 125) was used principally for screening ovarian cancer (Frederick et al, 2011).…”