Relationship Between Bilirubin Level and Disease Activity in Crohn’s Disease

doi:10.4328/jcam.4506

Cited by 1 publication

(3 citation statements)

References 17 publications

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“…The main contributors to TAS, apart from albumin, are bilirubin and uric acid. When assessed individually, total bilirubin has been consistently and in accord with the results on TAS, reported to be decreased in IBD [10,53,[74][75][76] (Table 1 and Supplementary Table S4) with an exception ofŞen et al [50], who found bilirubin in CD patients to be elevated. As bilirubin is a standardized biochemical parameter, it has omitted several early steps in the process of marker development.…”

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Usupporting

confidence: 74%

“…The bilirubin reduction extent matched patients' classification into inactive CD -CD of mild activity -CD of moderate activity -CD of severe activity categories [53]. Contrary to all reports discussed above,Şen et al [50] recorded a drop in total bilirubin in their CD patients with inactive disease and an increase in active form of the disease.…”

Section: Progression Markers In CDmentioning

confidence: 64%

“…Among non-enzymatic protein antioxidants (if not otherwise stated, reviewed in Supplementary Table S4), the most popular one was albumin, although its concentrations have usually been reported in addition to other compounds and rarely information other than its levels in particular study groups has been provided. Except for two reports [47,50], serum/plasma albumin has been observed to drop in IBD, regardless the disease type and activity [20,[51][52][53][54]. Also, albumin concentration in saliva has been significantly reduced [17].…”

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 82%

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Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

et al. 2020

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Precise diagnostic biomarker in inflammatory bowel diseases (IBD) is still missing. We conducted a comprehensive overview of oxidative stress markers (OSMs) as potential diagnostic, differential, progression, and prognostic markers in IBD. A Pubmed, Web of Knowledge, and Scopus search of original articles on OSMs in IBD, published between January 2000 and April 2020, was conducted. Out of 874 articles, 79 eligible studies were identified and used to prepare the interpretative synthesis. Antioxidants followed by lipid peroxidation markers were the most popular and markers of oxidative DNA damage the least popular. There was a disparity in the number of retrieved papers evaluating biomarkers in the adult and pediatric population (n = 6). Of the reviewed OSMs, a promising performance has been reported for serum total antioxidant status as a mucosal healing marker, mucosal 8-OHdG as a progression marker, and for multi-analyte panels of lipid peroxidation products assessed non-invasively in breath as diagnostic and differential markers in the pediatric population. Bilirubin, in turn, was the only validated marker. There is a desperate need for non-invasive biomarkers in IBD which, however, will not be met in the near future by oxidative stress markers as they are promising but mostly at the early research phase of discovery.

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