Relationship between Benign Prostatic Hyperplasia and International Prostatic Symptom Score

Raza, Iffat; Hassan, Nuzhat; Jafri, Anis; Gul, Pashmina

doi:10.9734/bjmmr/2015/19965

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…97.3 percent of the patients in the present study complaint of lower urinary tract symptoms with or without hematuria, in 2015 Raza et al 8 also published a similar study in which they found lower urinary tract symptoms as most common presenting symptom.…”

Section: Discussionsupporting

confidence: 63%

Correlation of serum PSA level with histomorphologic study in prostatic diseases

Kumari¹,

Sharma²,

Sharma³

et al. 2020

IJPO

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Introduction: Worldwide, diseases of prostate gland are responsible for significant morbidity and mortality among adult males. Prostate cancer is the second common cause of cancer related death in men after lung cancer but it can be completely cured if detected in early stage. Aim: To evaluate the histomorphological spectrum of non-neoplastic and neoplastic lesions of prostate and to establish the correlation of histomorphological findings with serum prostate specific antigens levels. Materials and Methods: 1 year Prospective Study was done on 110 patient at Department of Pathology , Indira Gandhi Medical College, Shimla, H.P from 1 st July 14 to 30 th June 15. Unwilling patient, inadequate biopsies and patient with metastatic carcinoma to prostate were excluded from study. Paraffin embedded sections were stained with routine haematoxylin and eosin stain. The PSA levels were estimated in biochemistry department using automated Chemiluminescence method on Beckman Coulter Access -II System. These values were correlated with histopathological diagnosis. Result: With 63.3%, benign prostatic hyperplasia was the most common lesion followed by Malignancy in 29.1% and prostatic intraepithelial neoplasia in 7.3% of total cases. Serum prostate specific antigens level was increased in 65.5% cases. Mean serum prostate specific antigens value of benign prostatic hyperplasia with and without inflammation is and10.9ng/ml and9.8ng/ml respectively. Mean serum prostate specific antigens value is 18.9 ng/ml in Low Grade and78.5 ng/ml in high grade prostatic intraepithelial neoplasm. Mean serum prostate specific antigen in malignancy was 101.2ng/ml antigen in. Conclusion: On statistical analysis PSA is found to be a sensitive and early marker for the diagnosis of prostate cancer. With a cut off value of 4ng/ml sensitivity was found to be 93.75% and specificity was 46.15%.

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Section: Discussionsupporting

confidence: 63%

Correlation of serum PSA level with histomorphologic study in prostatic diseases

Kumari¹,

Sharma²,

Sharma³

et al. 2020

IJPO

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“…Obstructive LUTS in prostatomegaly is due to compression of the prostatic urethra. Aslamet al [13] and Raza et al [14] also found LUTS as the most common presenting symptom correlated with our study.…”

Section: Discussionsupporting

confidence: 90%

Correlation between serum PSA, gleason score and histopathological grading of adenocarcinoma of prostate in patients undergoing TRUS guided prostatic biopsy in a tertiary care centre of Southern India

Reddy¹,

Karthikesh²,

Hussain³

et al. 2021

ann urol oncol

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Background Prostate cancer is the second most common cancer and the fifth leading cause of cancer deaths worldwide. Serum psa, a glycoprotein and a serine protease, which is increased in all prostatic diseases but markedly elevated levels are indicative of carcinoma prostate. The present study was done to evaluate the histopathologyof carcinoma of prostate in trus guided prostatic biopsy specimens and correlate serum psa levels with gleason score and grade groups. Methods A hundred patients presented with luts and suspicious of carcinoma prostate underwent trus guided 16 core prostatic biopsy. Histopathological examination, gleason scores and grades of biopsies were obtained. Based on the gleason scores, patients with carcinoma of the prostate were divided into five-grade groups. Mean serum psa levels were calculated and correlated with gleason score and grade groups. Results Malignancy was found in 69 per cent of cases, of which 68 patients were found to have adenocarcinoma of the prostate, one patient found to have undifferentiated carcinoma of the prostate. The total number of patients in each gleason grade groups were obtained, and the mean serum psa levels of these patients in each group were calculated. Mean serum psa levels in each group are group 1 (21.3 ng/ml), group 2 (58.4 ng/ml), group 3 (73.6 ng/ml), group 4 (118.4 ng/ml), group 5 (96.3 ng/ml). Conclusion Serum psa is a highly sensitive tumour marker with low specificity, and its levels are increased in many benign and iatrogenic conditions. Psa has a high negative predictive value which is essential in ruling out malignancy. In our study, higher serum psa levels were correlated with higher gleason score and grades.

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“…The total score ranges from 0 to 35 (asymptomatic to symptomatic) (9) . The Symptom index is categorized as mild (≤7), moderate (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and severe (≥20). For symptomatic score classification, IPSS divides the symptoms into obstructive and irritative symptoms as assessed by questionnaire (10) .…”

Section: Introductionmentioning

confidence: 99%

“…Voiding symptoms are incomplete emptying, intermittency, weak stream and straining. Benign Prostatic Hyperplasia has been used to explain a group of obstructive and storage symptoms (11,12) ". This study was conducted to identify that among IPSS, which of the following symptoms whether obstructive/ voiding and irritative/storage were more closely linked with BPH patients.…”

Section: Introductionmentioning

confidence: 99%

Correlation of international prostatic symptom score with prostate volume

Raza¹,

Mohiuddin²,

Ahmed³

et al. 2023

JRMC

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Objective: To evaluate the correlation of International Prostatic Symptom Score with Prostate Volume of Benign Prostatic Hyperplasia patients. Study Design: A Cross- out sectional study was done. Qualitative variables measured by Chi square test and quantitative by ANOVA. Pearson correlation & multinominal regression were applied. P value considered significant at <0.05. It was conducted in a tertiary care hospital, Ziauddin University Hospital Karachi. Methodology: The data was collected from 103 Benign prostatic hyperplasia patients. Prostate Volume of BPH patient were recorded by transabdominal ultrasonography in Radiology department. Severity of symptoms were assessed by IPSS questionnaire. Result: Mean IPSS was found out to be ±13.7. Clinical presentation showed hesitancy & nocturia as most frequently occurring symptoms in benign prostatic hyperplasia patient, these symptoms were found to be statistically significant with prostatic volume. Conclusion: IPSS strongly correlated with prostate volume. Irritative voiding symptoms have shown more association with increasing prostate volume. Keywords: Benign Prostatic Hyperplasia, Prostate Volume, International Prostatic Symptom Score, Lower Urinary Tract Symptoms.

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Relationship between Benign Prostatic Hyperplasia and International Prostatic Symptom Score

Cited by 6 publications

References 34 publications

Correlation of serum PSA level with histomorphologic study in prostatic diseases

Correlation of serum PSA level with histomorphologic study in prostatic diseases

Correlation between serum PSA, gleason score and histopathological grading of adenocarcinoma of prostate in patients undergoing TRUS guided prostatic biopsy in a tertiary care centre of Southern India

Correlation of international prostatic symptom score with prostate volume

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