Relationship between Autistic Traits and Nutrient Intake among Japanese Children and Adolescents

Tsujiguchi, Hiromasa; Miyagi, Sakae; Nguyen, Thao Thi Thu; Hara, Akinori; Kambayashi, Yasuhiro; Shimizu, Yukari; Nakamura, Haruki; Suzuki, Keita; Suzuki, Fujio; Nakamura, Hiroyuki

doi:10.3390/nu12082258

Cited by 17 publications

(15 citation statements)

References 40 publications

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“…Pantothenic acid (vitamin B5) was observed to have three significant correlations in the TD cohor, but was not found to have any such relationships in the ASD group ( Figure 3 and Figure 4 ). This nutrient has been shown in the literature to have a lower prevalence in the plasma of ASD [ 81 ]. Tryptophan was observed to be significantly correlated with pantothenic acid for the TD cohort but was not found to have any such relationship for the ASD group ( Figure 3 and Figure 4 ).…”

Section: Discussionmentioning

confidence: 99%

Multivariate Analysis of Metabolomic and Nutritional Profiles among Children with Autism Spectrum Disorder

Qureshi

Adams

Audhya³

et al. 2022

JPM

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There have been promising results regarding the capability of statistical and machine-learning techniques to offer insight into unique metabolomic patterns observed in ASD. This work re-examines a comparative study contrasting metabolomic and nutrient measurements of children with ASD (n = 55) against their typically developing (TD) peers (n = 44) through a multivariate statistical lens. Hypothesis testing, receiver characteristic curve assessment, and correlation analysis were consistent with prior work and served to underscore prominent areas where metabolomic and nutritional profiles between the groups diverged. Improved univariate analysis revealed 46 nutritional/metabolic differences that were significantly different between ASD and TD groups, with individual areas under the receiver operator curve (AUROC) scores of 0.6–0.9. Many of the significant measurements had correlations with many others, forming two integrated networks of interrelated metabolic differences in ASD. The TD group had 189 significant correlation pairs between metabolites, vs. only 106 for the ASD group, calling attention to underlying differences in metabolic processes. Furthermore, multivariate techniques identified potential biomarker panels with up to six metabolites that were able to attain a predictive accuracy of up to 98% for discriminating between ASD and TD, following cross-validation. Assessing all optimized multivariate models demonstrated concordance with prior physiological pathways identified in the literature, with some of the most important metabolites for discriminating ASD and TD being sulfate, the transsulfuration pathway, uridine (methylation biomarker), and beta-amino isobutyrate (regulator of carbohydrate and lipid metabolism).

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Section: Discussionmentioning

confidence: 99%

Multivariate Analysis of Metabolomic and Nutritional Profiles among Children with Autism Spectrum Disorder

Qureshi

Adams

Audhya³

et al. 2022

JPM

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“…In recent years, increasing attention has been paid to the nutritional status of children with ASD. The complex psychopathological picture that includes restricted interests or repetitive behaviour, disability in social reciprocity and abnormal communication that are characteristic of ASD strongly influences children’s eating behaviour [ 11 , 12 , 13 , 14 ]. Epidemiological studies reported that 46–89% of children with ASD exhibit feeding difficulties (five times more common among children with ASD than typically developing children) [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Supplementation on Levels of Homovanillic and Vanillylmandelic Acids in Children with Autism Spectrum Disorders

Kałużna–Czaplińska

2022

Metabolites

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Autism Spectrum Disorders (ASD) are characterized by numerous comorbidities, including various metabolic and nutritional abnormalities. In many children with ASD, problems with proper nutrition can often lead to inadequate nutrient intake and some disturbances in metabolic profiles, which subsequently correlate with impaired neurobehavioural function. The purpose of this study was to investigate and compare the relationship between supplementation, levels of homovanillic acid (HVA) and vanillylmandelic acid (VMA) and the behaviour of children with ASD using quantitative urinary acid determination and questionnaires provided by parents/caregivers. The study was carried out on 129 children between 3 and 18 years of age. HVA and VMA were extracted and derivatized from urinary samples and simultaneously analyzed by gas chromatography-mass spectrometry (GC-MS). In addition, parents/caregivers of children with ASD were asked to complete questionnaires containing information about their diet and intake/non-intake of supplements. The application of the Mann–Whitney U test showed a statistically significant difference between the level of HVA and vitamin B supplementation (p = 1.64 × 10−2) and also omega-6 fatty acids supplementation and the levels of HVA (p = 1.50 × 10−3) and VMA (p = 2.50 × 10−3). In some children, a reduction in the severity of autistic symptoms (better response to own name or better reaction to change) was also observed. These results suggest that supplementation affects the levels of HVA and VMA and might also affect the children’s behaviour. Further research on these metabolites and the effects of supplementation on their levels, as well as the effects on the behaviour and physical symptoms among children with ASD is needed.

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“…Meguid et al ( 14 ) found that Egyptian children with ASD consumed more carbohydrates but lower protein than healthy controls. Tsujiguchi et al ( 15 ) found that children with ASD consumed more carbohydrates but slightly less protein, fat, minerals, and vitamins than children without ASD in Japan. A nutritional survey in Chongqing, China suggested that Children with ASD consumed fewer macronutrients and vitamin A ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Association between dietary quality and executive functions in school-aged children with autism spectrum disorder

et al. 2022

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BackgroundIt is well known that children with autism spectrum disorder (ASD) had executive functions deficit. However, it is still unclear whether the poor dietary quality is related to the impairment of executive functions. The current study aimed to explore the association between dietary quality and executive functions in children with ASD.MethodsA total of 106 children with ASD (7.7 ± 1.3 years) and 207 typically developing (TD) children (7.8 ± 1.3 years) were enrolled from Guangzhou, China. The Chinese version of Behavior Rating Scale of Executive function (BRIEF), the working memory subscales of the Chinese version of Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV), and the Stroop Color-Word Test (SCWT) were used to measure the participant's executive functions. The food frequency questionnaire (FFQ) was used to collect the dietary intake information, and the Chinese Diet Balance Index (DBI_16) was used to evaluate the dietary quality. Generalized linear models were used to estimate the association between dietary quality and executive functions.ResultsIn children with ASD, Low Bound Score (LBS) was positively correlated with the working memory subscale score of BRIEF (β = 0.23, 95% CI: 0.02–0.44, P < 0.05), while High Bound Score (HBS) and LBS were positively correlated with the organizable subscale score of BRIEF (β = 0.44, 95% CI: 0.11–0.77, P < 0.01; β = 0.19, 95% CI: 0.01–0.37, P < 0.05). Compared to TD children, children with ASD had a higher proportion of moderate and high levels of insufficient dietary intake (moderate level, 37.7% vs. 23.2%, high level, 4.7% vs. 1.4%) and moderate level of unbalanced dietary intake (36.8% vs.21.3%), higher scores on all subscales of BRIEF (P < 0.01), and lower score on the working memory (81.3 ± 32.3 vs. 104.6 ± 12.5, P < 0.01), while there was no difference on the SCWT.ConclusionPoor dietary quality was associated with the impairment of working memory and organizational capacity in children with ASD. This study emphasized the importance of dietary quality in executive functions among children with ASD, and attention should be paid to improving their dietary quality.

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Relationship between Autistic Traits and Nutrient Intake among Japanese Children and Adolescents

Cited by 17 publications

References 40 publications

Multivariate Analysis of Metabolomic and Nutritional Profiles among Children with Autism Spectrum Disorder

Multivariate Analysis of Metabolomic and Nutritional Profiles among Children with Autism Spectrum Disorder

Effect of Supplementation on Levels of Homovanillic and Vanillylmandelic Acids in Children with Autism Spectrum Disorders

Association between dietary quality and executive functions in school-aged children with autism spectrum disorder

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