Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis

Chung, Hai Lee; Kim, Woo Taek; Kim, Jin‐Kyung; Choi, Eun Jin; Lee, Jun Hwa; Lee, Gyeong Hoon; Kim, Sang Gyung

doi:10.1016/s1081-1206(10)61307-5

Cited by 26 publications

(20 citation statements)

References 36 publications

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“…The A2 strain has been shown either not to express IL-13 and mucus or to down-regulate those responses 11,13 while generating significant levels of IL-10 and interferon-␥. [35][36][37] Previous studies have examined the consequences of IL-10 depletion in knockout animals and in animals overexpressing IL-10 but not neutralization during infection in a normal animal during primary infection. 38,39 The overexpression of IL-13 in lungs of mice has been clearly linked to pathophysiological changes in not only allergic responses but in several other instances, including RSV infection.…”

Section: Discussionmentioning

confidence: 99%

Differential Immune Responses and Pulmonary Pathophysiology Are Induced by Two Different Strains of Respiratory Syncytial Virus

Lukacs

Moore

Rudd

et al. 2006

The American Journal of Pathology

142

159

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Section: Discussionmentioning

confidence: 99%

Differential Immune Responses and Pulmonary Pathophysiology Are Induced by Two Different Strains of Respiratory Syncytial Virus

Lukacs

Moore

Rudd

et al. 2006

The American Journal of Pathology

142

159

View full text Add to dashboard Cite

“…The relevance of virus-stimulated cytokine production to clinical outcome is made explicit by strong associations between decreased levels of IFN-␥ and IL-10 production with increased severity of RSV infection (36,37,62). Similarly, it will be important to determine the extent to which the weaker capacity of MPV to induce IFN-␥ and IL-10 in vitro may relate to symptom severity and clinical outcomes during infection.…”

Section: Discussionmentioning

confidence: 99%

Human Metapneumovirus Elicits Weak IFN-γ Memory Responses Compared with Respiratory Syncytial Virus

Douville¹,

Bastien

et al. 2006

The Journal of Immunology

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Human metapneumovirus (MPV) is a recently discovered pathogen that causes repeated lower respiratory tract infections beginning in infancy. The prevalence, nature and control of human regulatory responses to MPV are unknown. In this study, we develop and optimize systems to evaluate MPV-driven cytokine responses. Using primary culture of human PBMC from previously exposed adults, MPV-stimulated responses were directly compared with those elicited by genetically and clinically similar respiratory syncytial virus (RSV). Intense IL-6 production was evident following culture with infectious or inactivated RSV. MPV elicited IL-6 responses averaging 3.5-fold more intense (p < 0.001). Virus-dependent expression of IL-11, IL-12, IFN-α, and other innate immunity cytokines differed little between MPV and RSV. When examining adaptive immunity, RSV infection elicited strong IFN-γ responses by all 60 adults. In marked contrast, MPV elicited IFN-γ in a lower frequency of adults (p < 0.002) and at levels averaging 6-fold weaker (p < 0.001). These Th1-dominated responses were CD4, CD8, CD86 dependent, and were closely paralleled by strong virus-driven IL-10 and CCL5 production. For MPV and RSV, Th2 (IL-5, IL-13) responses were sporadic, occurring in 10–40% of the population. Thus, MPV and RSV, although both ubiquitous and leading to very high levels of infection, seroconversion, and clinically similar presentation in the population, evoke distinct innate and adaptive T cell-dependent cytokine responses. Although both viruses yield Th1-dominated responses with strong IL-10 and CCL5 production, MPV restimulation results in markedly more robust IL-6 and significantly weaker adaptive cytokine responses, in both prevalence and intensity, than does RSV.

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“…IL-10 is also an important regulatory cytokine that is involved in many aspects of the immune response, and it seems to dysregulate in human autoimmune [18][19][20][21], malignant [13,[22][23][24][25][26][27], and infectious [28][29][30] disease. IL-10 production has also been implicated in the tumorigenesis of various types of cancers [23,31,32], and may also protect tumors by inhibiting cytotoxic T lymphocyte (CTL)-mediated tumor-specific cell lysis [33,34].…”

Section: Discussionmentioning

confidence: 99%

The involvement of genetic polymorphism of IL-10 promoter in non-small cell lung cancer

et al. 2005

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Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis

Cited by 26 publications

References 36 publications

Differential Immune Responses and Pulmonary Pathophysiology Are Induced by Two Different Strains of Respiratory Syncytial Virus

Differential Immune Responses and Pulmonary Pathophysiology Are Induced by Two Different Strains of Respiratory Syncytial Virus

Human Metapneumovirus Elicits Weak IFN-γ Memory Responses Compared with Respiratory Syncytial Virus

The involvement of genetic polymorphism of IL-10 promoter in non-small cell lung cancer

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