Relationship between atherosclerosis and the sleep apnea syndrome: An intravascular ultrasound study

Turmel, Julie; Sériès, Frédéric; Boulet, Louis‐Philippe; Poirier, Paul; Tardif, Jean‐Claude; Rodès-Cabeau, J.; Larose, Éric; Bertrand, Olivier

doi:10.1016/j.ijcard.2007.11.063

Cited by 62 publications

(34 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, an independent association between AHI and the median coronary artery calcification score was found in OSA patients who were free of CAD symptoms (47). Indeed, a significant relationship was demonstrated between the coronary atherosclerotic plaque volume and AHI as well as sleep fragmentation in OSA patients with stable CAD (48).…”

Section: Cardiovascular Mechanisms Of Cad In Osamentioning

confidence: 90%

Cardiovascular consequences of sleep apnea: II-Cardiovascular mechanisms

Celen¹,

Peker²

2010

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Section: Cardiovascular Mechanisms Of Cad In Osamentioning

confidence: 90%

Cardiovascular consequences of sleep apnea: II-Cardiovascular mechanisms

Celen¹,

Peker²

2010

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

“…The severity of nocturnal oxygen desaturation has been found as the best predictor for carotid wall hypertrophy, plaque occurrence and volume in OSA-patients 4,5,19 . Using atherosclerotic-prone mice fed on a highcholesterol diet, Jun et al recently showed that long term exposure to IH (4 to 12 weeks) accelerated atherosclerotic plaque growth 11 .…”

Section: The Proatherogenic Role Of Ihmentioning

confidence: 96%

Inflammation contributes to the atherogenic role of intermittent hypoxia in apolipoprotein-E knock out mice

et al. 2011

View full text Add to dashboard Cite

“…Furthermore, studies utilising carotid ultrasonography have shown severe OSA to be associated with increased carotid intima medial thickness (IMT), a validated early marker of coronary atherosclerosis [9]. Meanwhile, direct evidence supporting a deleterious impact of OSA on the coronary circulation comes from observational studies of clinic patients assessing coronary artery plaque burden using intravascular ultrasound [10], and coronary artery calcification using coronary computed tomographic angiography (CTA) [11].…”

Section: Introductionmentioning

confidence: 99%

Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary computed tomographic angiography study

et al. 2013

View full text Add to dashboard Cite

Obstructive sleep apnoea (OSA) is associated with significantly increased risk of cardiovascular disease. Carotid ultrasonography and retrospective, uncontrolled, coronary imaging studies have suggested an association of OSA with subclinical atherosclerosis, but there is a lack of prospective, controlled studies directly evaluating the relationship of OSA with occult coronary artery disease.We performed coronary computed tomographic angiography and inpatient-attended sleep studies on a cohort of otherwise healthy males attending our sleep laboratory, and compared coronary artery plaque volume between subjects with low and high apnoea/hypopnoea index (AHI) scores.29 subjects participated. The median AHI was 15.5 events?h -1 , with subjects who scored above this classified as high AHI. No significant differences were observed in demographic, anthropometric and clinical variables between the high-and low-AHI groups. Coronary plaque volume was significantly greater in the high-AHI group (mean plaque volume 2.6¡0.7 mm 2 versus 0.8¡0.2 mm 2 ; p50.017) and, furthermore, correlated significantly with AHI (Spearman's r50.433; p50.019). Following adjustment for dyslipidaemia and fasting plasma glucose levels, AHI remained a significant predictor of plaque volume (standardised b=0.424; p50.027).In this prospective case-control study, we found that severity of OSA may predict occult coronary atherosclerosis in otherwise healthy overweight or obese male subjects. @ERSpublications Increasing OSA severity predicts a greater burden of occult coronary artery disease in healthy overweight or obese males http://ow.ly/nSXEU

show abstract

Relationship between atherosclerosis and the sleep apnea syndrome: An intravascular ultrasound study

Cited by 62 publications

References 43 publications

Cardiovascular consequences of sleep apnea: II-Cardiovascular mechanisms

Cardiovascular consequences of sleep apnea: II-Cardiovascular mechanisms

Inflammation contributes to the atherogenic role of intermittent hypoxia in apolipoprotein-E knock out mice

Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary computed tomographic angiography study

Contact Info

Product

Resources

About