Relationship between atherosclerosis and knee osteoarthritis as graded by radiography and ultrasonography in females

Abstract

[Purpose] The aim of this study was to assess the relationship between atherosclerosis and knee osteoarthritis grade in women as assessed by both ultrasonography and radiography. [Subjects and Methods] Seventy women diagnosed with knee osteoarthritis were classified into two groups according to cartilage grading/radiographic grading. Patients with Kellgren-Lawrence grades 1 and 2 were included in group 1, while those with Kellgren-Lawrence grades 3 and 4 were included in group 2. Patients with cartilage grades 1–3 were included in group 1, while those with cartilage grades 4–6 were included in group 2. Patients were clinically assessed using a visual analog scale and the Western Ontario and McMaster Universities Arthritis Index. Radiographic osteoarthritis grade was scored using the Kellgren and Lawrence grading system. Using ultrasonography, symptomatic knees were graded and evaluated for distal femoral cartilage thickness. Carotid intima-media thickness and serum lipid levels were measured to assess atherosclerosis. [Results] Carotid intima-media thickness measurements were higher in group 2 than in group 1 as determined by the Kellgren-Lawrence and cartilage grading systems. Carotid intima-media thickness measurements were positively correlated with both the ultrasonographic cartilage grade and Kellgren-Lawrence. [Conclusion] The results of this study suggest that osteoarthritis as assessed by ultrasonography was successful and comparable to assessment with radiography. We showed a correlation between atherosclerosis and ultrasonographic knee osteoarthritis grade.

Assessment of Carotid Atherosclerosis in Patients with Knee Osteoarthritis

“…Also, in agreement with the findings of the present study, Ekim et al found that the duration of knee symptoms, WOMAC total and subscales scores were significantly higher in group with higher US grades than in group with lower US grades. Moreover, in agreement with our findings, the results of Ekim et al revealed that cIMT was directly correlated with the K-L grades and also with US cartilage thickness grades in patients with KOA [34].…”

“…In addition, it is evidenced that OA patients are at an increased risk of mortality due to CVD [10]. In agreement with our findings, Ekim et al [34] found that the duration of knee symptoms, WOMAC total and subscales scores were significantly higher in group 2 (KOA patients with KL grade of 3 and 4) than in group 1 (KOA patients with grade 1 and 2).…”

The role of oxidation of low-density lipids in pathogenesis of osteoarthritis: A narrative review

“…Cemeroglu et al 27 also reported a significant relationship between severe coronary stenosis and hand OA. An association between knee OA and the severity of AS was also suggested by Ekim et al 28 Few cohort studies have demonstrated that hand, knee, and hip OA are associated with AS. [29][30][31] An association between progression of OA and AS has been previously reported.…”

Acupuncture Decreased the Risk of Coronary Heart Disease in Patients with Osteoarthritis in Taiwan: A Nationwide Matched Cohort Study

“…Several studies have postulated the possible association between OA and atherosclerosis. 10,13 While traditionally OA was considered to be a degenerative joint disorder, nowadays, it is being observed as a disorder that is highly correlated to the metabolic syndrome and chronic inflammation plays an important role in the pathogenesis of OA, as well as with other comorbidities like diabetes mellitus, hypertension, and cardiovascular disease. 28 Apart from its analgesic effects, acupuncture has been shown to exert anti-inflammatory effects.…”

“…11 Oxidative stress, in which diet may also contribute to this condition, has a role with vascular pathogenesis and the progression of coronary heart disease (CHD). 12 Studies have also shown an association between atherosclerosis and OA, 13,14 and the suspected underlying mechanism is vascular alterations that cause a disruption in the circulation of the synovial membrane and subchondral bone, which leads to cartilage destruction. 10,15 Acupuncture, which is part of Traditional Chinese Medicine (TCM) treatment modalities, is commonly used in Asia, 16 and in recent years, its popularity has increased in Western countries.…”