Relationship between Arterial Stiffness Assessed by Brachial-Ankle Pulse Wave Velocity and Coronary Artery Disease Severity Assessed by the SYNTAX Score

Abstract

Aim:The SYNTAX score is a semi-quantitative angiographic tool used to determine the extent and severity of coronary artery disease (CAD). Automatic computer-assisted measurement of the brachial-ankle pulse wave velocity (baPWV) is a reproducible and valid method by which to assess arterial stiffness. Limited information is available for the association between the SYNTAX score and arterial stiffness in a CAD patient. We aim to assess the association between arterial stiffness determined by PWV and CAD severity assessed by angiography and the SYNTAX score. Methods: 321 subjects underwent measurement of both baPWV and angiography from 2010 to 2011. BaPWV was divided into tertiles. Multiple logistic and linear regression analyses were used to evaluate the relationship between the SYNTAX score and baPWV. Results: After adjusting for age, body mass index, smoking habits, family history of CAD, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), total cholesterol, triglycerides, LDL-cholesterol, fasting glucose, serum creatinine, uric acid and cysteine proteinase, analyses revealed that baPWV groups were significantly associated with the SYNTAX score. Compared with the lowest baPWV tertile, the adjusted odds ratios (ORs) of having a SYNTAXHIG for the MID and HIG baPWV tertiles were 4.76 (95% confidence interval: 1.71-6.33) and 4.13 (95% confidence interval: 1.12-5.27), respectively. We also used multiple linear regression analyses to assess the association between baPWV and the SYNTAX score, which showed that baPWV was associated with the SYNTAX score. Conclusion: Arterial stiffness determined by PWV is related to CAD severity assessed by angiography and the SYNTAX score.

Central aortic pressure, arterial stiffness and echocardiographic parameters of children with overweight/obesity and arterial hypertension

“…Obesity is known to be associated with greater arterial stiffness and increased incidence of cardiovascular disease in adulthood. 2,19 Our findings are consistent with the results of previous studies, in which children and adolescents with overweight/obesity presented with higher values of PWV than their peers with normal body weight. 8,9,20 One previous study demonstrated a correlation between PWV and continuous metabolic syndrome score in Indian children.…”

Gender difference in the association between brachial-ankle pulse wave velocity and cardiovascular risk scores

“…Therefore, there had been a concern whether baPVW could play a role instead of cfPWV. However, baPWV is easier to perform than cfPWV, therefore it is more commonly used in clinical practice, and its usefulness and prognostic value have been proven in various clinical settings [7][8][9][10][11][12] and meta-analysis [3,13]. In addition, it has been reported that baPWV shows good correlation with cfPWV [42] and aortic stiffness obtained by invasive recording [6].…”

“…Recently, the brachialankle PWV (baPWV) measurement, which is easy to perform, has become available in clinical practice [6]. Its validity and usefulness were proven in various clinical settings [7][8][9][10][11][12] and meta-analysis [3,13].…”

Prognostic Value of Brachial–Ankle Pulse Wave Velocity in Patients With Takayasu Arteritis With Drug‐Eluting Stent Implantation

“…Recently, some studies have demonstrated the correlation between arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV) and the complexity of CAD as evaluated by the SS in CAD patients (11,12). Although arterial stiffness and CAD are closely related, the correlation between arterial stiffness and the complexity of CAD in TAK patients has not been examined.…”