Relationship between Arg753Gln Toll-like receptor 2 and Asp299Gly Toll-like receptor 4 genetic variations and susceptibility to colorectal cancer in Southern Iran

Hosseini, Seyed Vahid; Mojtahedi, Zahra; Beizavi, Zahra; Khazraei, Hajar; Zamani, Mozhdeh

doi:10.2298/abs180812043h

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…1). [12–15,17–76] Among them, there were 25,969 people in the case group and 32,119 in the control group. The diseases involved in case groups include prostate cancer, lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, etc.…”

Section: Resultsmentioning

confidence: 99%

Association of TLR4 gene 2026A/G (rs1927914), 896A/G (rs4986790), and 1196C/T (rs4986791) polymorphisms and cancer susceptibility: Meta-analysis and trial sequential analysis

Wang

Wen

et al. 2023

Medicine

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Background: This study was performed to assess the association of TLR4 gene 2026A/G (rs1927914), 896A/G (rs4986790), and 1196C/T (rs4986791) polymorphisms and cancer susceptibility based on published case-control studies. Methods: Web of Science, PubMed, Embase, CBM, WanFang Data, CNKI, and VIP database were used for article retrieving. Then, these articles were screened according to the study inclusion and exclusion criteria. The data was extracted, and the study quality was evaluated according to the principle of Newcastle-Ottawa Scale. Meta-analysis was performed by RevMan 5.4 and Stata MP-17 software. Trial sequential analysis was performed by TSA 0.9.5.10 Beta software. Results: Eighty-seven case-control studies including 25,969 cases and 32,119 controls were included in the meta-analysis. The diseases involved in case groups include prostate cancer, lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, etc. A versus G model of rs1927914, A versus G model of rs4986790 and C versus T model of rs4986791 showed that odds ratio (OR) = 1.08, OR = 0.85, and OR = 0.74 respectively. All the 3 comparisons were statistically significant. Sensitivity analysis showed that the results were stable. Publication bias analysis and trial sequential analysis showed that no significant publication bias was found in the results of the meta-analysis, and the probability of false positives was small. Conclusion: People with A allele of rs1927914, G allele of rs4986790, or T allele of rs4986791 have higher risks of cancer. The results of meta-analysis are stable and have less probability of false positives.

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Section: Resultsmentioning

confidence: 99%

Association of TLR4 gene 2026A/G (rs1927914), 896A/G (rs4986790), and 1196C/T (rs4986791) polymorphisms and cancer susceptibility: Meta-analysis and trial sequential analysis

Wang

Wen

et al. 2023

Medicine

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show abstract

“…Of all the TLRs that are functional in humans, the single nucleotide polymorphisms (SNPs) of five TLR genes— TLR2 , 3 , 4 , 5 , and 9 —have been reported to be involved in modulating the risk of CRC extensively [ 17 , 21 , 22 , 25 , 28 , 49 , 101 , 102 ]. SNPs in any gene results in the change of amino acid sequence (missense/frameshift) which alters the structure and activity of the involved protein [ 103 ].…”

Section: Toll-like Receptor Polymorphism and Colorectal Cancermentioning

confidence: 99%

Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility

Sameer

Nissar

2021

BioMed Research International

149

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Toll-like receptors (TLRs) are the important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity. Numerous studies in different populations across the continents have reported on the significant roles of TLR gene polymorphisms in modulating the risk of colorectal cancer (CRC). CRC is one of the major malignancies affecting the worldwide population and is currently ranking the third most common cancer in the world. In this review, we have attempted to discuss the structure, functions, and signaling of TLRs in comprehensive detail together with the role played by various TLR gene SNPs in CRC susceptibility.

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“…9 No. 3 A study in the south of Iran on 150 patients with colorectal cancer and 150 control people showed a significant relationship between the TLR2 Arg753Gln polymorphism and colorectal cancer [32]. A metaanalysis study revealed that rs5743708 polymorphism was related to hepatocellular carcinoma (HCC) and decreased survival of patients with stages III and IV of advanced colon cancer [33].…”

Section: Vol 9 Nomentioning

confidence: 99%

The Relationship between Torque teno Virus and TLR2 rs5743708 Polymorphism with Breast Cancer

Komijani

Hamta

Hezaveh

2021

JoMMID

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Relationship between Arg753Gln Toll-like receptor 2 and Asp299Gly Toll-like receptor 4 genetic variations and susceptibility to colorectal cancer in Southern Iran

Abstract: Relationship between Arg753Gln Toll-like receptor 2 and Asp299Gly Toll-like receptor 4 genetic variations and susceptibility to colorectal cancer in Southern Iran.

Cited by 5 publications

References 28 publications

Association of TLR4 gene 2026A/G (rs1927914), 896A/G (rs4986790), and 1196C/T (rs4986791) polymorphisms and cancer susceptibility: Meta-analysis and trial sequential analysis

Association of TLR4 gene 2026A/G (rs1927914), 896A/G (rs4986790), and 1196C/T (rs4986791) polymorphisms and cancer susceptibility: Meta-analysis and trial sequential analysis

Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility

The Relationship between Torque teno Virus and TLR2 rs5743708 Polymorphism with Breast Cancer

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