Relationship between anthropometric factors, radiation exposure, and colon cancer incidence in the Life Span Study cohort of atomic bomb survivors

Semmens, Erin O.; Kopecky, Kenneth J.; Grant, Eric J.; Mathes, Robert; Nishi, Nobuo; Sugiyama, Hiromi; Moriwaki, Hiroko; Sakata, Ritsu; Soda, Midori; Kasagi, Fumiyoshi; Yamada, Michiko; Fujiwara, Saeko; Akahoshi, Masazumi; Davis, Scott; Kodama, Kazunori; Li, Christopher I.

doi:10.1007/s10552-012-0086-8

Cited by 8 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The positive association between BMI and overall colon cancer risk observed in our study is compatible with the results of a systematic review and meta‐analysis of prospective studies . It is also in agreement with an earlier LSS study by Semmens et al . As before, radiation and BMI risk estimates changed little after mutual adjustment and radiation risk did not vary according to BMI levels.…”

Section: Discussionsupporting

confidence: 92%

“…It is also in agreement with an earlier LSS study by Semmens et al . As before, radiation and BMI risk estimates changed little after mutual adjustment and radiation risk did not vary according to BMI levels.…”

Section: Discussionsupporting

confidence: 86%

“…Earlier studies of the atomic bomb survivors noted that BMI and radiation exposure have effects on the incidence of colon cancer . However, other lifestyle factors have not been considered to adjust for background rate or effect modification of radiation risk of colorectal cancer incidence in previous analyses in the survivors.…”

Section: Introductionmentioning

confidence: 99%

“…12,16,17 Earlier studies of the atomic bomb survivors noted that BMI and radiation exposure have effects on the incidence of colon cancer. 18 However, other lifestyle factors have not been considered to adjust for background rate or effect modification of radiation risk of colorectal cancer incidence in previous analyses in the survivors. The subsite-specific analyses of colorectal cancer risk in atomic bomb survivors have not been updated and there remain questions concerning the difference in radiation risks for proximal colon, distal colon and rectum after controlling for lifestyle factors.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Radiation risk of incident colorectal cancer by anatomical site among atomic bomb survivors: 1958–2009

Sugiyama

Misumi

Brenner

et al. 2019

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

Radiation effects on colorectal cancer rates, adjusted for smoking, alcohol intake and frequency of meat consumption and body mass index (BMI) by anatomical subsite (proximal colon, distal colon and rectum) were examined in a cohort of 105,444 atomic bomb survivors. Poisson regression methods were used to describe radiation‐associated excess relative risks (ERR) and excess absolute rates (EAR) for the 1958–2009 period. There were 2,960 first primary colorectal cancers including 894 proximal, 871 distal and 1,046 rectal cancers. Smoking, alcohol intake and BMI were associated with subsite‐specific cancer background rates. Significant linear dose–responses were found for total colon (sex‐averaged ERR/Gy for 70 years old exposed at age 30 = 0.63, 95% confidence interval [CI]: 0.34; 0.98), proximal [ERR = 0.80, 95% CI: 0.32; 1.44] and distal colon cancers [ERR = 0.50, 95% CI: 0.04; 0.97], but not for rectal cancer [ERR = 0.023, 95% CI: −0.081; 0.13]. The ERRs for proximal and distal colon cancers were not significantly different (p = 0.41). The ERR decreased with attained age for total colon, but not for proximal colon cancer, and with calendar year for distal colon cancer. The ERRs and EARs did not vary by age at exposure, except for decreasing trend in EAR for proximal colon cancer. In conclusion, ionizing radiation is associated with increased risk of proximal and distal colon cancers. The ERR for proximal cancer persists over time, but that for distal colon cancer decreases. There continues to be no indication of radiation effects on rectal cancer incidence in this population.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Radiation risk of incident colorectal cancer by anatomical site among atomic bomb survivors: 1958–2009

Sugiyama

Misumi

Brenner

et al. 2019

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…Initiation and development of cancers, particularly colonic cancer is a very complex one with several variables playing crucial roles in sustaining the viability of the cancer. Even though initiations of colonic cancers are well attributed to genetic imbalances, which could be inherited [ 1 ] or somatic origin [ 2 ], other environmental under-linings have been proposed, including alcohol consumption [ 3 , 4 ], tobacco use [ 5 , 6 ], obesity [ 7 , 8 ], radiations [ 9 , 10 ] and physical inactivity [ 11 ]. It could be conjectured that some of latter variables target or influence genetic imbalances, but others are not well known or understood.…”

Section: Introductionmentioning

confidence: 99%

Mucin expression patterns in histological grades of colonic cancers in Ghanaian population

et al. 2017

View full text Add to dashboard Cite

IntroductionMyriad roles of mucins in normal tissues have been well documented, including lubrication of the epithelial surfaces; protection from physical damage; facilitation in cell-cell signaling and suppression of inflammatory activity. Pathological expression of mucins has been noted in cancer development and progression. This study sought to identify and quantify the types of mucins produced during various histological grades of colon cancer and to assess the diagnostic significance.MethodsFormalin fixed, paraffin-embedded tissue blocks, comprising three (3) normal colon and twenty-two (22) colon cancer tissues, were retrieved from the archives of the histopathology department of the Komfo Anokye Teaching Hospital. They were stained with Haematoxylin and eosin (H&E) for diagnosis and grading of tumours. Tissues were pre-digested with diastase and stained with Alcian blue (pH 2.5)/Periodic Acid Schiff to characterize the mucin variants present.ResultsOur findings indicated that normal colonic tissues expressed exceptionally high amount of acid mucin and low amount of neutral mucin. However, there was a general decrease in mucin expression in colon cancers compared to normal colon tissues. Additional findings suggested that as cancer progresses from low grade to high grade of adenocarcinoma of the colon, there was generally a considerable decrease in the acid mucin production and an increase in the neutral mucin expression. In contrast, a sizeable subpopulation of high-grade adenocarcinomas of colon showed a rather opposite mucin expression pattern- increase in acid mucin and a decrease in neutral mucin.ConclusionAs colonic cancer progresses, there are corresponding changes in the mucin types and content such that there are decrease in acid mucin and increase in neutral mucin expressions.

show abstract

Radiation and Health Effects

Ray¹,

Stick²

2015

Handbook of Toxicology of Chemical Warfare Agents

View full text Add to dashboard Cite

Relationship between anthropometric factors, radiation exposure, and colon cancer incidence in the Life Span Study cohort of atomic bomb survivors

Cited by 8 publications

References 25 publications

Radiation risk of incident colorectal cancer by anatomical site among atomic bomb survivors: 1958–2009

Radiation risk of incident colorectal cancer by anatomical site among atomic bomb survivors: 1958–2009

Mucin expression patterns in histological grades of colonic cancers in Ghanaian population

Radiation and Health Effects

Contact Info

Product

Resources

About