Relationship between anemia, hypoalbuminemia, vitamin D deficiency and quality of life in advanced non-small cell lung carcinoma patients at tertiary hospital in Bali

Abstract

Background: The main purpose of treatment in patients with advanced lung cancer is more emphasizing on prolonging survival and improving the patient's quality of life (QOL). Micronutrient deficiency has an impact on the patient's QOL. The purpose of this study was to analyse the relationship between biochemical parameters of nutrient deficiency with QOL in patients with advanced non-small cell carcinoma (NSCLC) at Sanglah hospital.Methods: A cross sectional study was conducted in Sanglah general hospital on March-June 2021. Hemoglobin, albumin, and 2.5 (OH) D levels were obtained from patient's serum. The participant’s QOL was measured with EQ-5D-3L questionnaire. Bivariate analysis using chi-square test or Fisher's exact test, and multivariate analysis using logistic regression.Results: A total of 80 participants were included in this study, and 55% had poor QOL. Seventy percent participants had anemia, 36.3% had hypoalbuminemia, and 26.3% had vitamin D deficiency. The QOL of patients with advanced stage NSCLC was significantly associated with hypoalbuminemia (p=0.000) and vitamin D deficiency (p=0.044). Multivariate analysis showed that the most influential factor on the QOL of patients with advanced stage NSCLC was hypoalbuminemia (AOR 9.158; 95% CI 2.150-30.001; p=0.003).Conclusions: Hypoalbuminemia and vitamin D deficiency were significantly related with QOL of advance NSCLC patients. No relationship was found between anemia and the QOL of advance NSCLC patients. Hypoalbuminemia was the most influential factors related to the QOL of advance NSCLC patients.

relationship of lactate dehydrogenase, pH, glucose and protein pleural fluids with one year life of patients with non-small cell lung carcinoma with malignant pleural effusion in Prof. Dr IGNG Ngoerah Denpasar

“…This is in line with previous research at Prof. Hospital. Dr IGNG Ngoerah, as many as 55% of the samples received systemic chemotherapy, and TKI was the most widely used treatment (Ekaruna et al, 2021). The current study shows that chemotherapy provides a significant advantage in survival in lung cancer patients.…”

“…Most of the nutritional status of the study sample with normal nutrition as many as 35 people (46.1%). These results are similar to the results of previous studies at Prof. Dr. I.G.N.G Ngoerah Hospital was found in 50 people (62.5%) with normal nutritional status in NSCLC patients (Ekaruna et al, 2021). In some studies, weight loss is associated with a poorer prognosis.…”

“…This is in line with research at Prof. Hospital. Dr. IGNG Ngoerah previously found 55 people (68.8%) who did not smoke (Ekaruna et al, 2021).…”

“…This is by research at Prof. Hospital. Previously, IGNG Ngoerah had 17 NSCLC patients (21.3%) as farmers (Ekaruna, et al, 2021). Some jobs, such as farmers dealing with pesticides, and work dealing with solvents, or materials that can be easily inhaled, are known to increase a person's risk of developing work-related lung cancer.…”

“…A total of 5 people (5.6%) in the study sample had genetic risk factors, while 71 people (93.4%) did not have genetic risk factors. This is also under research at Prof. Dr. I.G.N.G Ngoerah Hospital previously found that 65 people (81.2%) had no family history of cancer (Ekaruna et al, 2021). This is also by the research by Sinaga et al ( 2022) in Dr H. Abdul Moeloek Hospital, Lampung Province, in 2018-2021, the results for lung cancer were not had a family history of 190 patients (77.9%) and a family history of 54 patients (22.1%).…”