Relationship Between Alcoholism and Morphogenesis of Cirrhosis

Natural History of Alcoholic Hepatitis. IV. GLYCOSAMINOGLYCURONANS AND COLLAGEN IN THE HEPATIC CONNECTIVE TISSUE

“…Yet these livers showed only minimal parenchymal necrosis and no PMN-leukocytic inflammatory exudate on hematoxylin-eosin-stained sections. Continued active fibrosis is compatible with the observations that demonstrated the transformation of the micronodular (Laennec's) cirrhosis to a macronodular (postnecrotic-type) cirrhosis (39,40). This type of transformation was observed in those cirrhotic patients who stopped drinking and in whom alcoholic hepatitis subsided.…”