Natural History of Alcoholic Hepatitis. IV. GLYCOSAMINOGLYCURONANS AND COLLAGEN IN THE HEPATIC CONNECTIVE TISSUE

Alcohol‐Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study†

“…Alcohol‐related liver disease covers a spectrum including fatty liver disease, alcoholic hepatitis, and cirrhosis and its complications. The type and severity of steatosis and extent of fibrosis are independent predictive factors of fibrosis progression and the highest risk of disease progression is observed in heavy drinkers with alcoholic hepatitis . Approximately 3% of patients with alcoholic hepatitis progress to cirrhosis annually.…”

Alcohol-related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study

“…Alcohol-related liver disease covers a spectrum including fatty liver disease, alcoholic hepatitis, and cirrhosis and its complications. The type and severity of steatosis and extent of fibrosis are independent predictive factors of fibrosis progression and the highest risk of disease progression is observed in heavy drinkers with alcoholic hepatitis (20)(21)(22)(23). Approximately 3% of patients with alcoholic hepatitis progress to cirrhosis annually.…”

“…It is proposed to use the term "moderate alcoholic hepatitis" for patients with alcoholic hepatitis and MELD 11-20; and mild alcoholic hepatitis with MELD ≤10. The three-month natural history of moderate alcoholic hepatitis (MELD score [11][12][13][14][15][16][17][18][19][20] needs to be defined. It is also necessary to define whether pharmacological therapy is required for patients with moderate alcoholic hepatitis.…”

KASL Clinical Practice Guidelines: Management of Alcoholic Liver Disease

“…Drink excessively, may induce recurrent episodes of alcoholic hepatitis in patients with ALD, and if this is severe or associated with liver cirrhosis, complications occur due to liver failure and portal hypertension, leading to a high short-term mortality. In addition, long-term follow-up of these patients has shown that they rarely improve, instead usually remaining with alcoholic hepatitis or progressing to liver cirrhosis 56. Liver fibrosis is common in alcoholic hepatitis and is accelerated in the presence of chronic alcoholic hepatitis 57.…”