Alcohol‐Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study†

Szabó, Gyöngyi; Kamath, Patrick S.; Shah, Vijay H.; Thursz, Mark; Maury, Philippe

doi:10.1002/hep.30369

Cited by 71 publications

(59 citation statements)

References 72 publications

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“…As many developing countries have experienced significant economic expansion and improved living standards, a byproduct has been an alarming rise in alcohol consumption and subsequently ALD [35]. The prevalence rates of ALD were reported to be 4.5%, 6.2% 6%, and 1.56-2.34% in China, the US, Europe, and Japan, respectively [35,[44][45][46].…”

Section: Aldh and Alcoholic Liver Disease (Ald)mentioning

confidence: 99%

Aldehyde Dehydrogenase, Liver Disease and Cancer

Wang

et al. 2020

Int. J. Biol. Sci.

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Acetaldehyde dehydrogenase 2 (ALDH2) is the key enzyme responsible for metabolism of the alcohol metabolite acetaldehyde in the liver. In addition to conversion of the acetaldehyde molecule, ALDH is also involved in other cellular functions. Recently, many studies have investigated the involvement of ALDH expression in viral hepatitis, alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), liver fibrosis, and liver cancer. Notably, ALDH2 expression has been linked with liver cancer risk, as well as pathogenesis and prognosis, and has emerged as a promising therapeutic target. Of note, approximately 8% of the world's population, and approximately 30-40% of the population in East Asia carry an inactive ALDH2 gene. This review summarizes new progress in understanding tissue-specific acetaldehyde metabolism by ALDH2 as well as the association of ALDH2 gene polymorphisms with liver disease and cancer. New research directions emerging in the field are also briefly discussed.

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Section: Aldh and Alcoholic Liver Disease (Ald)mentioning

confidence: 99%

Aldehyde Dehydrogenase, Liver Disease and Cancer

Wang

et al. 2020

Int. J. Biol. Sci.

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“…Alcohol-associated liver disease (ALD) encompasses a clinical and histologic continuum which includes steatosis, alcoholic steatohepatitis, alcoholic hepatitis (AH), and cirrhosis. 50 The pathophysiology of ALD is complex and is impacted by genetic factors, oxidative stress, and inflammation. Neutrophil infiltration of the liver is known to correlate with mortality in AH.…”

Section: Neutrophil Extracellular Traps In Liver Disease Alcohol-assomentioning

confidence: 99%

Neutrophil Extracellular Traps and Liver Disease

Hilscher

Shah

2019

Semin Liver Dis

Self Cite

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Neutrophil extracellular traps, or NETs, are heterogenous, filamentous structures which consist of extracellular DNA, granular proteins, and histones. NETs are extruded by a neutrophil in response to various stimuli. Although NETs were initially implicated in immune defense, subsequent studies have implicated NETs in a spectrum of disease processes, including autoimmune disease, thrombosis, and cancer. NETs also contribute to the pathogenesis of several common liver diseases, including alcohol-associated liver disease and portal hypertension. Although there is much interest in the therapeutic potential of NET inhibition, future clinical applications must be balanced against potential increased risk of infection.

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“…These programs should include an accurate pre-transplant assessment, continuing pre-and post-transplant monitoring, and customized psychotherapy programs to enhance the patient's personal and family resources, and reduce the risk of relapses after liver transplantation [30,31]. This subject does however require additional studies to solve the controversy that still surrounds liver transplant selection criteria for alcohol-related cirrhosis patients [32,33].…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in Liver Transplant Recipients: A Retrospective Study

Girgenti

Tropea

Buttafarro

et al. 2020

IJERPH

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Background: This study aims to investigate the quality of life and the therapeutic compliance of the patients who received a liver transplant, from a living or deceased donor, at IRCCS ISMETT in the last three years. Liver transplantation is an effective therapeutic strategy for patients with end-stage liver failure. The quality of life (QOL) of liver disease patients is placed under considerable stress due to the debilitating clinical conditions and related issues experienced in everyday life by these individuals. The concept of QOL is being increasingly used to define the individual perception of health, including physical, mental, and social wellbeing. The success of a liver transplant should therefore be intended not only in terms of survival, but also of recovery of a satisfying quality of life. For this reason, our liver transplant recipients are closely monitored and supported from a psychological standpoint. This is done to monitor their ability to adapt to and comply with their clinical condition and to verify their gradual resumption of their path of life Methods: We retrospectively analyzed data collected by the IRCCS ISMETT Clinical Psychology Service during routine psychological follow-up of liver transplant recipients. Data refer to 82 patients who received a liver transplant between January 2017 and September 2019 and describe their QOL and therapeutic adherence. The obtained results were compared with the main studies on this issue available in literature. Results: Ninety-four percent of liver transplant recipients reported high mean scores of quality of life and therapeutic adherence 28% of patients reported at least one persistent annoying symptom after transplantation, although in some cases this did not affect the overall QOL. The results also refer to patients with a pre-transplant diagnosis of alcohol-related cirrhosis, who confirm their complete abstinence from alcohol. Conclusions: Our results confirm the efficacy of the liver transplantation to achieve of a good QOL. Furthermore, these patients seem to maintain high therapeutic adherence, thus ensuring a good outcome of the care received during the transplantation process.

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Alcohol‐Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study†

Cited by 71 publications

References 72 publications

Aldehyde Dehydrogenase, Liver Disease and Cancer

Aldehyde Dehydrogenase, Liver Disease and Cancer

Neutrophil Extracellular Traps and Liver Disease

Quality of Life in Liver Transplant Recipients: A Retrospective Study

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