Relationship between ABO Blood Groups and Lipid Profile Level in Healthy Adult Residents in Port Harcourt Metropolis, Nigeria

Bartimaeus, ES; Waribo, HA

doi:10.4314/jasem.v21i6.1

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…It has been shown in both experimental and clinical studies that higher plasma levels of LDL and cholesterol in non-O blood groups (A, AB, B) influence the susceptibility of these groups to cardiovascular diseases, while in the O blood group, higher levels of HDL tend to play a protective role in these systemic pathologies, − but the molecular mechanisms by which these group-specific pathologies are influenced have not yet been elucidated.…”

Section: Resultsmentioning

confidence: 99%

Association of Plasma Metabolites and Lipoproteins with Rh and ABO Blood Systems in Healthy Subjects

et al. 2022

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This study investigated the associations between the levels of 27 plasma metabolites, 114 lipoprotein parameters, determined using nuclear magnetic resonance spectroscopy, and the ABO blood groups and the Rhesus (Rh) blood system in a cohort of n = 840 Italian healthy blood donors of both sexes. We observed good multivariate discrimination between the metabolomic and lipoproteomic profiles of subjects with positive and negative Rh. In contrast, we did not observe significant discrimination for the ABO blood group pairwise comparisons, suggesting only slight metabolic differences between these group-specific metabolic profiles. We report univariate associations (P-value < 0.05) between the subfraction HDL1 related to Apo A1, the subfraction HDL2 related to cholesterol and phospholipids, and the particle number of LDL2 related to free cholesterol, cholesterol, phospholipids, and Apo B and the ABO blood groups; we observed association of the lipid main fraction LDL4 related to free cholesterol, triglycerides, and Apo B; creatine; the particle number of LDL5; the subfraction LDL5 related to Apo B; the particle number of LDL4; and the subfraction LDL4 related to Apo B with Rh blood factors. These results suggest blood group-dependent (re)shaping of lipoprotein metabolism in healthy subjects, which may provide relevant information to explain the differential susceptibility to certain diseases observed in different blood groups.

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Section: Resultsmentioning

confidence: 99%

Association of Plasma Metabolites and Lipoproteins with Rh and ABO Blood Systems in Healthy Subjects

et al. 2022

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“…Non-O blood groups have been associated with an increased risk of cardiovascular diseases [ 42 , 43 ]. On the other hand, all blood groups have been associated with low levels of HDL and therefore, higher cardiovascular risk profiles [ 44 ]. In contrast, only blood group B was associated with higher HDL in this study specifically among men.…”

Section: Discussionmentioning

confidence: 99%

HDL and associated factors stratified by sex and menopausal status: results from a community-based survey in Taiwan

et al. 2018

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AimTo investigate factors, especially modifiable factors associated with high-density lipoprotein (HDL) in Taiwanese based on sex and menopausal status.Materials and MethodsParticipants comprised 2022 men and 2392 women (1267 menopausal and 1125 non-menopausal) aged ≥30 years who resided in Pingzhen district, Taoyuan from 2006-2011. Their data, obtained through questionnaires and measurements were retrieved from the Li-Shin Hospital.ResultsHigher HDL was associated with total cholesterol, underweight, and alcohol drinking in both men and women. It was also associated with education, blood group B, and marital status in men as well as with age in women. Moreover, it was associated with total cholesterol, underweight, and age in both menopausal and non-menopausal women. Furthermore, it was associated with marital status in non-menopausal women and alcohol drinking in menopausal women. Lower HDL was associated with triglycerides, low-density lipoprotein (LDL), overweight, obesity, waist-hip ratio (WHR), uric acid, and smoking in both men and women and with coffee drinking in only women. It was also associated with uric acid, triglycerides, LDL, overweight, obesity, WHR, and body fat in both menopausal and non-menopausal women. Moreover, it was associated with coffee drinking in menopausal women.ConclusionModifiable factors associated with HDL differ according to sex and menopausal status. Sex and menopausal status should be considered when implementing lifestyle changes to raise HDL. For example, both men and women should maintain a normal weight as well as quit smoking.

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“…In an effort to understand the relationship between ABO blood group phenotypes and evidence underpinning an association between the ABO blood group system and the risk of developing CVD, several epidemiological studies have characterized lipid profile distributions in individuals with or without metabolic disease across the ABO blood group system [7,10,[12][13][14]. However, research examining the metabolic health status of individuals according to ABO blood group, which may be an important genetic determinant for CVD processes, remains limited.…”

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confidence: 99%

Metabolic health status and cardiovascular risk of different ABO blood group phenotypes

Anioke¹

2019

Int J Med Biochem

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Metabolic health status and cardiovascular risk of different ABO blood group phenotypes C linically, certain cardio-metabolic risk determinants often occur in a cluster of components of obesity, dyslipidemia, hypertension, and hyperglycemia [1]. This formed the basis of the definition of metabolic syndrome (MetSyn). Various sets of criteria for the diagnosis of MetSyn have been proposed using a different number and combination of these compo-Objectives: ABO blood group antigens could play a role in the pathogenesis of cardiovascular disease (CVD). This study examined the metabolic health status (MHS) and CVD risk of apparently healthy individuals from across the ABO blood group system. Methods: Demographic details as well as anthropometric and biochemical data were collected in a cross-sectional survey from 120 participants of different ABO groups (range: 18-70 years). Height, weight, and waist circumference were measured using standard procedures. Body mass index was calculated as weight divided by height squared (kg/ m 2). A blood sample of approximately 5 mL was collected after an overnight fast. Fasting blood glucose was estimated using a glucometer. The blood group was determined using a monoclonal ABO blood grouping reagent. Direct enzymatic methods and a commercial kit were used to measure the level of total cholesterol (TC), triglycerides, and highdensity lipoprotein. Low-density lipoprotein (LDL) and very low-density lipoproteins were estimated using the Friedewald equation. Metabolically healthy (MH) and metabolically unhealthy (MUH) individuals were identified based on the presence of metabolic syndrome using the Joint Interim Statement criteria. CVD risk was determined using the Systematic Coronary Risk Evaluation chart. Results: Females showed significant differences in TC across the ABO system: The O group (mean±SD: 4.85±0.77 mmol/L) demonstrated a significantly higher TC level compared with the A group (mean±SD: 4.22±0.72 mmol/L; p=0.015). The LDL in females was also significantly higher in the O group samples (mean±SD: 3.06±0.75 mmol/L) compared with the A samples (mean±SD: 2.53±0.62 mmol/L; p=0.042). There was no significant difference between the MUH and MH groups based on ABO blood phenotype (p>0.05). The CVD risk among those with the O phenotype (51.7%) was significantly higher than in the non-O blood groups among male subjects (χ 2 =6.213; p=0.045). Conclusion: MHS was not associated with the ABO system, but there is a possibility that male members of blood group O are more susceptible to CVD than men with non-O phenotypes.

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Relationship between ABO Blood Groups and Lipid Profile Level in Healthy Adult Residents in Port Harcourt Metropolis, Nigeria

Cited by 3 publications

References 19 publications

Association of Plasma Metabolites and Lipoproteins with Rh and ABO Blood Systems in Healthy Subjects

Association of Plasma Metabolites and Lipoproteins with Rh and ABO Blood Systems in Healthy Subjects

HDL and associated factors stratified by sex and menopausal status: results from a community-based survey in Taiwan

Metabolic health status and cardiovascular risk of different ABO blood group phenotypes

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