Association of Plasma Metabolites and Lipoproteins with Rh and ABO Blood Systems in Healthy Subjects

Cesare, Francesca Di; Tenori, Leonardo; Luchinat, Claudio; Saccenti, Edoardo

doi:10.1021/acs.jproteome.2c00375

Cited by 4 publications

(5 citation statements)

References 46 publications

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“…Therefore, our results and previous studies suggest a link of ABO gene polymorphisms with protection against ACS that may be partially related with HDL-C. The association of ABO groups with HDL plasma levels has been previously reported [ 35–37 ] presupposing a modification of lipoprotein metabolism but the mechanisms involved are still unknown [ 35 ]. Additional studies, such as GWAS, exome sequencing studies, and recently “exome chip” in a larger number of individuals should be undertaken.…”

Section: Discussionsupporting

confidence: 74%

ABO gene polymorphisms are associated with acute coronary syndrome and with plasma concentration of HDL-cholesterol and triglycerides

Vargas‐Alarcón¹,

Pérez-Méndez²,

Posadas-Sánchez³

et al. 2023

Biomol Biomed

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The role of ABO gene polymorphisms in acute coronary syndrome (ACS) and lipid metabolism is increasingly recognized. We investigated whether ABO gene polymorphisms are significantly associated with ACS and the plasma lipid profile. Six ABO gene polymorphisms (rs651007 T/C, rs579459 T/C, rs495928 T/C, rs8176746 T/G, rs8176740 A/T, and rs512770 T/C) were determined by 5’exonuclease TaqMan assays in 611 patients with ACS and 676 healthy controls. The results demonstrated that the rs8176746 T allele was associated with a lower risk of ACS under the co-dominant, dominant, recessive, over-dominant, and additive models (P=0.0004, P=0.0002, P=0.039, P=0.0009, and P=0.0001, respectively). Furthermore, under co-dominant, dominant, and additive models, the rs8176740 A allele was associated with a lower risk of ACS (P=0.041, P=0.022, and P=0.039, respectively). On the other hand, the rs579459 C allele was associated with a lower risk of ACS under the dominant, over-dominant, and additive models (P=0.025, P=0.035, and P=0.037, respectively). In a subanalysis performed with the control group, rs8176746 T and rs8176740 A alleles were associated with low systolic blood pressure and with both high HDL-C and low triglyceride plasma concentrations, respectively. In conclusion, ABO gene polymorphisms were associated with a lower risk of ACS, and lower systolic blood pressure and plasma lipid levels, suggesting a causal relationship between ABO blood groups and the incidence of ACS.

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Section: Discussionsupporting

confidence: 74%

ABO gene polymorphisms are associated with acute coronary syndrome and with plasma concentration of HDL-cholesterol and triglycerides

Vargas‐Alarcón¹,

Pérez-Méndez²,

Posadas-Sánchez³

et al. 2023

Biomol Biomed

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“…The mechanism for the association of RhD− individuals with subclinical atherosclerosis might be related to the fact that lipoproteins have been shown to differ between RhD groups but not between ABO groups [ 13 ]. However, one study reported a better lipid profile in RhD− compared to RhD+ individuals [ 14 ], which contradicts our results.…”

Section: Discussionmentioning

confidence: 99%

“…The ABO blood group system has previously been associated with several circulatory diseases [ 5 , 6 , 7 ], and it is stated that non-O blood group individuals are associated with increased incidence of arterial thromboembolic events [ 8 , 9 , 10 ], such as myocardial infarction (MI), but there are more conflicting results as to whether other forms of CVD are associated [ 10 , 11 , 12 ]. Few studies are available on the RhD blood group and its role in the pathogenesis of circulatory disease, but some have suggested that there are associations between RhD and dyslipidemia, which is a risk factor for CVD [ 13 , 14 ]. Studies assessing the roles of ABO and RhD in subclinical atherosclerosis as potential risk markers are sparse, and the studies available have primarily included individuals already considered high-risk.…”

Section: Introductionmentioning

confidence: 99%

ABO Blood Groups, RhD Factor and Their Association with Subclinical Atherosclerosis Assessed by Carotid Ultrasonography

Mickelsson,

Ekblom,

Stefansson

et al. 2024

JCM

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Background: The ABO blood group system has previously been associated with cardiovascular disease (CVD), where non-O blood group individuals have shown an increased risk. Studies assessing early atherosclerotic disease while also including RhD are few. We aimed to determine whether the ABO and RhD blood groups are associated with subclinical atherosclerosis in a healthy population. Methods: We included 3532 participants from the VIPVIZA trial with available carotid ultrasonography results to assess subclinical disease. Information about blood groups was obtained from the SCANDAT-3 database, where 85% of VIPVIZA participants were registered. Results: RhD− individuals aged 40 years showed increased carotid intima–media thickness (B 1.09 CI 95% 1.03; 1.14) compared to RhD+ individuals. For ABO, there were no differences in ultrasonography results when assessing the whole study population. However, 60-year-old individuals with heredity for CVD and a non-O blood group had decreased odds for carotid plaques (OR 0.54 CI 95% 0.33; 0.88). Conclusions: RhD blood group is associated with subclinical atherosclerosis in younger individuals, indicating a role as a mediator in the atherosclerotic process. In addition, a non-O blood group was associated with decreased subclinical atherosclerosis in individuals aged 60 and with heredity (corresponding to the group with the highest atherosclerotic burden).

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“…Accuracy, sensitivity, specificity, the area under the ROC curve (AUROC), and corresponding 95% CIs were calculated according to the standard definitions and given as average over the 100 re-samplings. The significance of the models was determined with a permutation-test using n = 1000 permutations [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

Exploration of Blood Metabolite Signatures of Colorectal Cancer and Polyposis through Integrated Statistical and Network Analysis

et al. 2023

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Colorectal cancer (CRC), one of the most prevalent and deadly cancers worldwide, generally evolves from adenomatous polyps. The understanding of the molecular mechanisms underlying this pathological evolution is crucial for diagnostic and prognostic purposes. Integrative systems biology approaches offer an optimal point of view to analyze CRC and patients with polyposis. The present study analyzed the association networks constructed from a publicly available array of 113 serum metabolites measured on a cohort of 234 subjects from three groups (66 CRC patients, 76 patients with polyposis, and 92 healthy controls), which concentrations were obtained via targeted liquid chromatography-tandem mass spectrometry. In terms of architecture, topology, and connectivity, the metabolite-metabolite association network of CRC patients appears to be completely different with respect to patients with polyposis and healthy controls. The most relevant nodes in the CRC network are those related to energy metabolism. Interestingly, phenylalanine, tyrosine, and tryptophan metabolism are found to be involved in both CRC and polyposis. Our results demonstrate that the characterization of metabolite–metabolite association networks is a promising and powerful tool to investigate molecular aspects of CRC.

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Association of Plasma Metabolites and Lipoproteins with Rh and ABO Blood Systems in Healthy Subjects

Cited by 4 publications

References 46 publications

ABO gene polymorphisms are associated with acute coronary syndrome and with plasma concentration of HDL-cholesterol and triglycerides

ABO gene polymorphisms are associated with acute coronary syndrome and with plasma concentration of HDL-cholesterol and triglycerides

ABO Blood Groups, RhD Factor and Their Association with Subclinical Atherosclerosis Assessed by Carotid Ultrasonography

Exploration of Blood Metabolite Signatures of Colorectal Cancer and Polyposis through Integrated Statistical and Network Analysis

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