Relationship among Visual Field, Blood Flow, and Neural Structure Measurements in Glaucoma

Hwang, J.; Konduru, Ranjith; Zhang, Xinbo; Tan, Ou; Francis, Brian A.; Varma, Rohit; Sehi, Mitra; Greenfield, David S.; Sadda, Srinivas R.; Huang, David

doi:10.1167/iovs.11-8552

Cited by 104 publications

(88 citation statements)

References 52 publications

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“…Sectoral blood flow has advantages over total retinal blood flow, 10,18 including, for instance, that it is possible to compare sectoral flow to sectoral nerve fiber loss or visual fields in glaucoma. 19 With measurements of oxygen saturation in individual retinal vessels, it will be possible to determine sectoral oxygen extraction, which, together with sectoral flow, will help to determine the local metabolic rate of oxygen consumption in the retina.…”

Section: Resultsmentioning

confidence: 99%

Total average blood flow and angiography in the rat retina

Srinivasan

Radhakrishnan

2013

J. Biomed. Opt

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Abstract. High-resolution angiography and total average blood flow measurements in the rat retina using optical coherence tomography (OCT) are presented. Recently, an en face integration method, which does not require explicit calculation of vessel angles, was introduced to calculate blood flow using Doppler OCT. Using this method, rapid two-dimensional scanning has been shown to quantify pulsatile flow. However, high scanning speeds sacrifice transverse sampling density and may lead to biased velocity estimates. Alternatively, we show here that by using a volumetric scanning protocol that asynchronously samples a single vessel with respect to the heartbeat, it is possible to obtain accurate time-averaged flow measurements, even without explicit information about the pulsatile waveform. Total average retinal blood flows calculated using either arteries or veins are comparable, supporting the accuracy of this method.

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Section: Resultsmentioning

confidence: 99%

Total average blood flow and angiography in the rat retina

Srinivasan

Radhakrishnan

2013

J. Biomed. Opt

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“…For this reason, we developed a semiautomated software tool, termed the Doppler OCT of Retinal Circulation (DOCTORC), to allow efficient manual identification and correction of corresponding vessel positions, and subsequent generation of retinal blood flow results. [8][9][10] With high-quality scans, the good reproducibility of this approach has been described in previous publications. [9][10] However, this method has important limitations that reduce the yield of scans with accurate or valid blood flow results.…”

Section: Introductionmentioning

confidence: 82%

Dual-Angle Protocol for Doppler Optical Coherence Tomography to Improve Retinal Blood Flow Measurement

Tan

Konduru

Zhang

et al. 2014

Trans. Vis. Sci. Tech.

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Purpose: To compare the performance of two different multiple-scan protocols for total retinal blood flow (TRBF) measurement using Doppler optical coherence tomography (OCT). Methods:In the ''single-angle'' protocol, five Doppler scans were acquired at a single beam angle. In the ''dual-angle'' protocol, three scans were obtained with the OCT beam passing through the supranasal portion of the pupil and three through the infranasal portion. The data were analyzed using a custom software termed ''Doppler OCT of Retinal Circulation'' (DOCTORC) to generate TRBF measurements. In DOCTORC, the measurement of a vein was considered unreliable if the Doppler angle was less than 38 or the coefficient of variation of Doppler angle was more than 50%. If the summated area of unreliable veins was larger than 50% of total venous area, the measurement of TRBF was considered not acceptable.Results: Ten subjects were scanned with both protocols. The Doppler angle (P 0.003, paired t-test) and Doppler shift (P 0.035) were significantly higher in the dualangle protocol. The yield rate, percent of eyes with valid TRBF measurement, was 80% using the dual-angle protocol and 60% from single-angle protocol. An additional 42 subjects were scanned with the single-angle protocol while 84 subjects with the dualangle protocol. Unpaired tests also showed significantly better yield rate (P ¼ 0.03). Conclusions:The dual-angle protocol improved Doppler shift level in OCT. This resulted in a greater percentage of cases in which TRBF could be reliably measured.Translational Relevance: The new scan protocol improved the practicality of TRBF measurement with Doppler OCT.

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“…По данным M. Victor и со-авт. [19], к возрасту 80 лет кровоток в сосудах мозга и зри-тельной системы снижается на 20% по сравнению с крово-током в возрасте 20 лет, и к тому же возрастные изменения гемодинамики в сетчатке сопровождаются снижением ре-активности сосудов зрительной системы на визуальную стимуляцию и нарушением механизмов регуляции крово-тока в сосудах зрительной системы и мозга [3,20].…”

Section: результаты и обсуждениеunclassified

“…Выявлено очень тесное сопряжение между функцио-нальной активностью фоторецепторов и других нейронов зрительной системы и кровотоком [3]. Кровоток в cетчатке и зрительной коре повышается во время светово-го воздействия, и его интенсивность снижается в сетчатке в процессе темновой адаптации [17].…”

Section: результаты и обсуждениеunclassified

Changes in light sensitivity of the visual system with age and in patients with ischemic optic neuropathy

Kubarko

2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Relationship among Visual Field, Blood Flow, and Neural Structure Measurements in Glaucoma

Cited by 104 publications

References 52 publications

Total average blood flow and angiography in the rat retina

Total average blood flow and angiography in the rat retina

Dual-Angle Protocol for Doppler Optical Coherence Tomography to Improve Retinal Blood Flow Measurement

Changes in light sensitivity of the visual system with age and in patients with ischemic optic neuropathy

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