Relationship among <i>α</i> amylase and carbonic anhydrase <scp>VI</scp> in saliva, visible biofilm, and early childhood caries: a longitudinal study

Borghi, Gabriela Novo; Rodrigues, Lívia Pagotto; Lopes, Lenita Marangoni; Parisotto, Thaís Manzano; Steiner‐Oliveira, Carolina; Nobre‐dos‐Santos, Marinês

doi:10.1111/ipd.12249

Cited by 37 publications

(66 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this context, Borghi et al revealed a direct relationship between α-amylase and CA VI from saliva, the visible bacterial biofilm, and early childhood caries. This longitudinal study found that CA VI activity was significantly higher in saliva of children with caries (P ≤ 0.05), and that α-amylase activity was significantly higher in saliva of caries-free children (P < 0.0001) ( Table 7) [71]. In the same framework, Colgate-Palmolive Company patented a kit diagnosing the amplified predisposition to enamel erosion in a mammal based on two methods, both measuring and quantifying the concentrations of proteins critical to proper enamel formation.…”

Section: Carbonic Anhydrase VI As a Disease Biomarkermentioning

confidence: 82%

Carbonic anhydrases as disease markers

Zamanova

Shabana

Mondal

et al. 2019

Expert Opinion on Therapeutic Patents

View full text Add to dashboard Cite

Introduction-The physiologic importance of fast CO 2 /HCO 3 interconversion in various tissues requires the presence of carbonic anhydrase (CA, EC 4.2.1.1). Fourteen CA isozymes are present in humans, all of them being used as biomarkers. Area covered-A great number of patents and articles were focused on the use of CA isozymes as biomarkers for various diseases and syndromes in the recent years, in an ascending trend over the last decade. The review highlights the most important studies related with each isozyme and covers the most recent patent literature. Expert opinion-The CAs biomarker research area expanded significantly in recent years, shifting from the predominant use of CA IX and CA XII in cancer diagnostic, staging and prognosis towards a wider use of CA isozymes as disease biomarkers. CA isozymes are currently used either alone, in tandem with other CA isozymes and/or in combination with other proteins for the detection, staging and prognosis of a huge repertoire of human dysfunctions and diseases, ranging from mild transformation of the normal tissues to extreme shifts in tissue organization and function. The techniques used for their detection/quantitation and the state-of-the art in each clinical application are presented through relevant clinical examples and corresponding statistical data.

show abstract

Section: Carbonic Anhydrase VI As a Disease Biomarkermentioning

confidence: 82%

Carbonic anhydrases as disease markers

Zamanova

Shabana

Mondal

et al. 2019

Expert Opinion on Therapeutic Patents

View full text Add to dashboard Cite

show abstract

“…Existen evidencias sobre la relación inversa entre los niveles de mucina en la saliva y la incidencia de caries 12,44 . En un estudio se compararon la actividad de αamilasa y otros parámetros salivales en niños libres de caries con niños con caries activas y se observó que el pH, la capacidad buffer y el nivel de calcio y fósforo aumentaron con la disminución de la actividad de caries en los niños, mientras que la actividad de α-amilasa se incrementó con el aumento de la actividad de caries 45,46 . Esto estaría relacionado con su actividad enzimática específica en la PA y en el biofilm cariogénico 19,47 .…”

Section: A) Cariesunclassified

Saliva: a pontential tool in Dentistry.

Barembarum¹,

Azcurra²

2019

RevFacOdont

View full text Add to dashboard Cite

Saliva is a biological fluid of complex composition that facilitates the interactions between host cells, oral microorganisms and immune modulators with the main purpose of maintaining oral health status. Within the salivary components, proteins are fundamental, because they are responsible for the main functions of saliva. Proteomic studies contributed to identify and characterize between 2,000 and 2,600 different proteins and peptides in their composition. Among them, a high proportion is glycoproteins, such as mucins, proteins rich in proline and immunoglobulins, agglutinins, lactoferrin, cystatins and lysozyme. In addition, saliva possesses peptides of potent antimicrobial activity and protection to mineral tissues, such as cathelicidin LL-37, α and β defensins, histatins and statins. In particular, in recent years the selection of biomarkers of oral diseases such as dental caries, periodontal diseases and oral cancer has been focused, considering the simple, economical and non-invasive obtaining of this fluid, which has driven the development of technologies for the detection of biomarkers with high sensitivity and specificity for a wide variety of oral diseases. The study of the components of saliva and its potential biomarkers makes this fluid a powerful tool for diagnosis and detection of diseases, as well as to evaluate the evolution of therapeutic treatments, because it reflects the physiological and pathological state of the body.KEY WORDS: salivary proteins and peptides, biomarkers, dental caries, periodontal diseases, oral cancer ResumenLa saliva es un líquido biológico de composición compleja que facilita las interacciones entre las células del huésped, los microorganismos bucales y los moduladores inmunológicos con el principal propósito de mantener el estado de salud bucal. Dentro de los componentes salivales, las proteínas son fundamentales por ser responsables de las principales funciones de la saliva. Los estudios proteómicos contribuyeron a identificar y caracterizar entre 2.000 a 2.600 proteínas y péptidos diferentes en su composición. Entre ellas, una alta proporción son glucoproteínas, como las mucinas, proteínas ricas en prolina e inmunoglobulinas, aglutininas, lactoferrina, cistatinas y lisozima. Además la saliva posee péptidos de potente actividad antimicrobiana y de protección a los tejidos minerales, como la catelicidina LL-37, α y β defensinas, histatinas y estaterinas. En particular, en los últimos años se ha profundizado la selección de biomarcadores de las enfermedades bucales como caries dental, enfermedades periodontales y cáncer bucal, considerando la sencilla, económica y poco invasiva obtención de este fluido, por lo que se ha impulsado el desarrollo de tecnologías para la detección de biomarcadores con alta sensibilidad y especificidad para una gran variedad de enfermedades bucales. El estudio de los componentes de la saliva y sus potenciales biomarcadores convierte a este fluido en una potente herramienta de diagnóstico y detección de enfermedades, como así también para eval...

show abstract

“…High sugar consumption is the primary risk factor [1]. There are multiple predisposing factors for ECC including those that increase the risk for high consumption of sugar, and those that increase tooth susceptibility to caries [2][3][4][5]. These factors have largely been studied at the individual level.…”

Section: Introductionmentioning

confidence: 99%

Association between early childhood caries and poverty in low and middle income countries

et al. 2020

View full text Add to dashboard Cite

Background: The aim of this study was to assess the relationship between early childhood caries (ECC) in 3-5-yearold children, seven indicators of poverty and the indicator of monetary poverty in low-and middle-income countries (LICs, MICs). Methods: This ecologic study utilized 2007 to 2017 country-level data for LICs and MICs. Explanatory variables were seven indicators of poverty namely food, water, sanitation, health, shelter, access to information, education; and monetary poverty. The outcome variable was the percentage of 3-5-year-old children with ECC. A series of univariate general linear regression models were used to assess the relationship between the percentage of 3-5 year-old children with ECC and each of the seven indicators of poverty, and monetary poverty. This was followed by multivariable regression models to determined the combined effect of the seven indicators of poverty, as well as the combined effect of the seven indicators of poverty and monetary poverty. Adjusted R 2 measured models' ability to explain the variation among LICs and MICs in the percentage of 3-5-year-old children with ECC. Results: Significantly more people had food, sanitation, shelter, access to information, education and monetary poverty in LICs than in MICs. There was no difference in the prevalence of ECC in 3-5-year-old children between LICs and MICs. The combination of the seven indicators of poverty explained 15% of the variation in the percentage of 3-5-year-old children with ECC compared to 1% explained by monetary poverty. When the seven indicators of poverty and the indicator for monetary poverty were combined, the amount of variation explained by them was 10%. Only two of the poverty indicators had a direct relationship with the percentage of children with ECC; there was a higher percentage of ECC in countries with higher percentage of population living in slums (B = 0.35) and in those countries with higher percentage of the population living below poverty lines (B = 0.19). The other indicators had an inverse relationship. Conclusion: The use of multiple indicators to measures of poverty explained greater amount of variation in the percentage of 3-5-year-olds with ECC in LICs and MICs than using only the indicator for monetary poverty.

show abstract

Relationship among α amylase and carbonic anhydrase VI in saliva, visible biofilm, and early childhood caries: a longitudinal study

Abstract: The presence of visible biofilm and low salivary activity of α amylase may be considered risk predictors for ECC.

Cited by 37 publications

References 38 publications

Carbonic anhydrases as disease markers

Carbonic anhydrases as disease markers

Saliva: a pontential tool in Dentistry.

Association between early childhood caries and poverty in low and middle income countries

Contact Info

Product

Resources

About