Relationseips Between Drug Dissolution Profile and Gelling Agent Viscosity in Tablets Prepared with Hydroxypropylmethylcellulose (HPMC) and Sodium Carboxymethylcellulose (NaCMC) Mixtures

Vázquez, M. J.; Gómez-Amoza, J.L.; Martínez‐Pacheco, Ramón; Souto, C.; Concheiro, Angel

doi:10.3109/03639049509070862

Cited by 10 publications

(3 citation statements)

References 15 publications

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“…Several mathematical models (zero-order, first-order, Higuchi, and Korsmeyer-Peppas) lately have been tested, in an attempt to understand the drug release mechanism from hydrophilic matrices. Baveja et al [16] and Vázquez et al [17] verified that one of the drawbacks of the mixtures containing hydrophilic swellable polymers is that the desirable zero-order kinetics are not usually attained. On the other hand, Bettini et al [18] using different cellulose ether derivatives, reported that matrix tablets prepared with low viscosity grade HPMC were more erodible.…”

Section: Introductionmentioning

confidence: 99%

Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M

Vueba

Carvalho²,

Veiga

et al. 2006

Pharmaceutical Development and Technology

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The influence of cellulose ether derivatives on ibuprofen release from matrix tablets was investigated. Raman spectroscopy and differential scanning calorimetry (DSC) experiments were used, in order to examine the compatibility between the matrix components: both excipients and ibuprofen. While both the DSC and Raman results did not detect any incompatibilities, DSC revealed the existence of some drug:excipient interactions, reflected by variations in the hydration/dehydration processes. Formulations containing mixtures of polymers with both low and high viscosity grades-methylcellulose (MC25) or hydroxypropylcellulose (HPC), and hydroxypropylmethylcellulose (HPMC K100M), respectively--were prepared by a direct compression method (using 20, 25, and 30% of either MC25 or HPC). The tablets were evaluated for their drug content, weight uniformity, hardness, thickness, tensile strength, friability, porosity, surface area, and volume. Parameters such as the mean dissolution time (MDT) and the dissolution efficiency (DE) were calculated in all cases. The solid formulations presently studied demonstrated a predominantly Fickian diffusion release mechanism.

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Section: Introductionmentioning

confidence: 99%

Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M

Vueba

Carvalho²,

Veiga

et al. 2006

Pharmaceutical Development and Technology

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“…NaCMC, as well as many other derivative polysaccharides, has a heterogeneous molecular weight distribution and chemical composition, which explain the diversity of molecular weight values found in the literature. Vázquez et al [26] characterized the average molecular weight of NaCMC of medium viscosity using a capillary viscometer and found [ƞ]=535 mL.g -1 and M v =124.94 kDa. Sharma et al [27] determined [ɳ]=198 cm 3 .g -1 and M v =90 kDa and Gomez-Diáz and Navaza [28] found [ɳ]=643.9 cm 3 .g -1 and M v =386 kDa.…”

Section: Molecular Weight Determinationmentioning

confidence: 99%

Stabilization of gelatin and carboxymethylcellulose water-in-water emulsion by addition of whey protein

2019

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ObstractDue to their aqueous nature and biocompatibility, water/water emulsions are particularly advantageous in the production of low calorie functional food and bioactive carrier microparticles. The aim of this study was to investigate the stability of water/water emulsions formed by gelatin and carboxymethycelullose through the Pickering effect, by addition of whey protein particles. The effect of phase composition and pH on emulsion stability over 3 days of storage was studied and the emulsion properties were characterized. Finally, the effect of the addition of different concentrations of whey protein particles on the emulsion stability was investigated. The added protein particles contributed to reduce the rate of phase separation and higher protein concentration showed this effect more clearly. The time of complete phase separation increased 12 h after addition of 15% (w/w) protein. Emulsions at pH 5.5 with protein particles, however, showed lower stability than those at pH 7.5 without particles.

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“…They can be used for controlled release of both water-soluble and water-insoluble drugs. Release of drugs from such matrices can be controlled through their physical properties, the correct choice of gelling agent and setting up the conditions for fabrication 7 .…”

Section: Modified-release Preparations May Be Prescribed Tomentioning

confidence: 99%

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2012

IJPSR

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Modified Release (MR) Formulations have a modification in the release mechanism. Modified release dosage forms are developed by altering drug absorption or the site of drug release in order to achieve predetermined clinical objectives. Modified drug release from dosage forms is complemented by the allied processes of drug design, of dosage administration, and of membrane transport and absorption of drug to the biological site of action. Modified-release drugs have complex formulations that can offer an advantage over standard medication for some patients. Modified-release preparations should only be used where there is a clear clinical advantage over conventional-release preparations. In general, Modified-release preparations should be reserved for specific patients where there is a problem with compliance, effectiveness or side-effects which these preparations could help overcome. Modified-release technologies have become indispensable to resolving critical technical, therapeutic, and marketing challenges, such as improving patience compliance, less dosage timings, better safety, better indications, delivering poorly soluble and poorly absorbable API's, product differentiation, patent protection, product lifecycle extension, and better margins. Modified-release formulation design can be conducted for oral and non-oral administration routes. Possible therapeutic benefits of an MR product include improved efficacy and reduced adverse events, increased convenience and patient compliance, optimized performance, a greater selectivity of activity, or new indications.

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Relationseips Between Drug Dissolution Profile and Gelling Agent Viscosity in Tablets Prepared with Hydroxypropylmethylcellulose (HPMC) and Sodium Carboxymethylcellulose (NaCMC) Mixtures

Cited by 10 publications

References 15 publications

Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M

Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M

Stabilization of gelatin and carboxymethylcellulose water-in-water emulsion by addition of whey protein

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