Relations of plasma 25-hydroxyvitamin D levels in mothers, cord blood and newborn infants, and postnatal changes in plasma 25-hydroxy-vitamin D levels.

Shimotsuji, Tsunesuke; Seino, Yoshiki; Ishida, Makoto; Ishii, Tadao; Ikehara, Chiiko; Hiejima, Teisuke; Yabuuchi, Hyakuji

doi:10.3177/jnsv.25.79

Cited by 8 publications

(4 citation statements)

References 10 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aside from obvious differences in methodology [5] we can only speculate on the importance of such factors as seasonal variation, dietary Ca, and vitamin D intake. We have previously reported [21], and other investigators also have repeatedly shown, a significant correlation between maternal and cord serum 25OHD concentrations [ 10]. In the present study as well, maternal and cord serum 25OHD concentrations are significantly correlated.…”

Section: Discussionsupporting

confidence: 74%

Serum calcium regulating hormones in the perinatal period

et al. 1982

Self Cite

View full text Add to dashboard Cite

To clarify perinatal vitamin D metabolism, we measured 25-hydroxyvitamin D (25OHD), 24,25-dihydroxyvitamin D [24,25(OH)2D], 1,25-dihydroxyvitamin D [1,25(OH)2D], calcium (Ca), phosphorus (P), parathyroid hormone (PTH), and human calcitonin (CT) in paired maternal, cord, and infant serum. Cord serum 25OHD was significantly lower than the maternal level, and cord serum 24,25(OH)2D was also significantly below the maternal concentrations. Maternal, cord, and infant serum 1,25(OH)2D, on the other hand, was significantly higher than the normal adult level. The serum PTH was low, but the CT concentration was high in the cord. Cord serum Ca and P levels were significantly higher than maternal. The reason for the elevated circulating 1,25(OH)2D level in the perinatal period is uncertain, and we speculate that the possible factors are gonadal steroids, placental lactogen, prolactin, and CT. In addition, serum 24,25(OH)2D and 1,25(OH)2D concentrations are under some control by the fetus.

show abstract

Section: Discussionsupporting

confidence: 74%

Serum calcium regulating hormones in the perinatal period

et al. 1982

Self Cite

View full text Add to dashboard Cite

show abstract

“…The presence of a low liver D3 sequestra tion during the first 2 weeks after birth may also be related to some observations made in infants in which circulating 25(OH)D con centrations were shown to either stay stable during the neonatal period [1,14,20] or to increase progressively during the first 3 months after birth [16,30], Moreover, in the rat, the requirement for 1,25-dihydroxy vita min D [l,25(OH)2D] for intestinal calcium absorption [6,11], the development of the intestinal l,25(OH)2D cytosolic receptor [12], as well as the increase in circulating l,25(OH)2D [11] were shown to coincide with the weaning period. These observations may then indicate that the requirement for 25(OH)D as a precursor of the hormone, l,25(OH)2D, is lower in neonates than in postsuckling and in mature animals.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, numerous studies have shown that the circulating 25(OH)D concentrations in the fetus or in the umbilical cord plasma were positively correlated to the circulating con centrations of 25(OH)D in the maternal plasma [1,2,4,15,18], Moreover, the pres ence of lower circulating 25(OH)D concen trations in the fetal than in the maternal cir culation has led to the hypothesis that 25(OH)D is most likely passively transferred to the fetus across the placental barrier [23, 30,31]. These observations have also led to the general belief that the fetus could rely on the maternal supply of 25(OH)D rather than that of unmetabolized vitamin D to meet his physiological need in vitamin D. However, some studies have shown that the parent compound, vitamin D, could also be trans ferred across the placenta [3,10,13].…”

Section: Introductionmentioning

confidence: 99%

Sequestration of <sup>3</sup>H-Vitamin D<sub>3</sub> by the Fetal and Neonatal Rat Liver

Martial¹,

Plourde²,

Gascon-Barré³

1985

Neonatology

View full text Add to dashboard Cite

19- to 21-day-old fetuses as well as 3-, 7-, 14-, and 22-day-old pups were used to evaluate the sequestration of a tracer dose of ³H-D₃ by the fetal and neonatal rat liver. In fetuses, ³H-D₃ was injected directly into the umbilical vein; in neonates, ³H-D₃ was injected into the portal vein. In both cases, ¹⁴C-sucrose was used as extracellular marker. ³H-D₃ sequestration was evaluated at 11.3 ± 1.1% (X ± SEM) in fetuses, 3.3 ± 0.6, 4.9 ± 0.6, 6.3 ± 0.5 and 42.0 ± 1.9% of the dose administered in 3-, 7-, 14-, and 22-day-old rats, respectively. These results clearly show that, in the rat, the fetal liver can take up ³H-D₃. Moreover, when compared to the values obtained in the late fetal period, ³H-D₃ uptake decreased significantly during the first 2 weeks post partum (p < 0.0001) and then dramatically increased (6-fold, p < 0.0001) between days 14 and 22 post partum, when it reached an uptake capacity similar to that previously observed in adult rats.

show abstract

“…Hillman et al (2) and Shimotsuji et al (4) showed that there was a significant correlation between the plasma levels of 25-OH-D in maternal and cord blood by using CPBA methods for the determination of the metabolite. However, since their CPBA methods used were incapable of separating 25-OH-D2 and 25-OH-D3, their results were merely shown as the total amounts of 25-OH-D. Vitamin D2 which shows practically the same physiological effects as vitamin D3 with humans has been predominantly added to commercial drugs (e.g., multivitamins preparations) and enriched foods (e.g., fortified dry milk) because of its lower price than vitamin D3 in Japan.…”

mentioning

confidence: 99%