Plasma levels of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in maternal,cord and neonatal blood.

Kuroda, Eizo; Okano, Toshio; Mizuno, Naoko; Kobayashi, Tadashi; Kodama, Soichl; Ninomiya, Michindo; Morishita, Yorihiko; Matsuo, Tamotsu

doi:10.3177/jnsv.27.55

Cited by 25 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All infants were of appro¬ priate size for their gestational age and were free or con-Accepted for publication February 11,1991. Eleven of the term and eight of the premature infants were male, The mean(±SD) gestational ages for the term and premature study infants were 39,8 ±1.1 and 30,9±1.5 weeks, respectively.…”

Section: Resultsmentioning

confidence: 99%

How Much Vitamin D for Neonates?

Pittard

Geddes²,

Hulsey³

et al. 1991

Arch Pediatr Adolesc Med

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

How Much Vitamin D for Neonates?

Pittard

Geddes²,

Hulsey³

et al. 1991

Arch Pediatr Adolesc Med

View full text Add to dashboard Cite

“…Earlier studies have shown seasonal variations in serum 25-hydroxyvitamin D (25-OHD; the major vitamin D metabolite in blood) concentrations in both pregnant women and their newborn infants, with low values in winter (Kuroda et al 1981;Verity et al 1981). Severe vitamin D deficiency in pregnancy can lead to intrauterine growth retardation (Brooke et al 1980), adverse effects on the appearance of neonatal ossification centres (Specker et al 1992) and congenital rickets (Moncrieff & Fadahunsi, 1974), confirming the potential impact of maternal vitamin D deficiency on fetal bone development.…”

Section: Seasonmentioning

confidence: 99%

Factors affecting newborn bone mineral content:in uteroeffects on newborn bone mineralization

Namgung

Tsang

2000

Proc. Nutr. Soc.

View full text Add to dashboard Cite

55Abbreviations: AGA, appropriate-for-gestational age; BMC, bone mineral content; BMD, bone mineral density; ICTP, cross-linked carboxy-terminal telopeptide of type I collagen; IDM, infants of diabetic mothers; 1, Recently, we found evidence of decreased bone formation rates in infants who were small-for-gestational age (SGA) compared with infants who were appropriate-forgestational age; we reported reduced BMC, cord serum osteocalcin (a marker of bone formation) and 1,25-dihydroxyvitamin D (the active metabolite of vitamin D), but no alterations in indices of fetal bone collagen metabolism. In theory, reduced utero-placental blood flow in SGA infants may result in reduced transplacental mineral supply and reduced fetal bone formation. Infants of diabetic mothers (IDM) have low BMC at birth, and infant BMC correlated inversely with poor control of diabetes in the mother, specifically first trimester maternal mean capillary blood glucose concentration, implying that factors early in pregnancy might have an effect on fetal BMC. The low BMC in IDM may be related to the decreased transplacental mineral transfer. Cord serum ICTP concentrations were higher in IDM than in control subjects, implying increased intrauterine bone resorption. BMC is consistently increased with increasing body weight and length in infants. Race and gender differences in BMC appear in early life, but not at birth. Ethanol consumption and smoking by the mother during pregnancy affect fetal skeletal development.

show abstract

“…Unfortunately, maternal levels of 25-OH VD and Ca during pregnancy or maternal BMC as the indicator of total Ca status were not measured in the present study. Earlier studies have revealed seasonal variations in serum 25-OH VD concentrations in both pregnant women and their newborn infants, with low values in winter ( 22 , 48 ) . Namgung et al found significant seasonal differences; summer-born infants had significantly lower BMC, higher 1,25-vitamin D levels and lower total Ca levels than winter-born infants.…”

Section: Discussionmentioning

confidence: 99%

Association between calcium in cord blood and newborn size in Bangladesh

et al. 2011

View full text Add to dashboard Cite

Ca status in the uterus during pregnancy has been suggested to affect fetal growth and size at birth. In Bangladesh, low Ca levels in pregnant women and low birth weight in infants are common. The present study explored the association between Ca levels in cord blood and newborn size at birth (birth weight and birth length) in Bangladesh. Samples and data included 223 women with live-born singleton deliveries in rural Bangladesh. Newborn weight and length were measured at birth. From cord blood obtained at delivery, Ca, 25-hydroxy vitamin D, bone-specific alkaline phosphatase and intact parathyroid hormone levels were determined. An association between size at birth and Ca levels in cord blood was found (birth weight, P¼ 0·022; birth length, P¼0·001). Associations between Ca and newborn size were further analysed using multivariate regression analyses. After adjusting for several covariates of characteristics in mothers and newborns (gestational weeks at birth, sex of newborn, socio-economic status, maternal height, BMI, age and season at birth), birth length still exhibited a significant relationship with Ca levels in cord blood (birth length, P¼0·030). The present study indicates that Ca status in cord blood might be associated with the birth length of newborns. Ca levels during gestation may affect fetal growth.

show abstract

Plasma levels of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in maternal,cord and neonatal blood.

Cited by 25 publications

References 8 publications

How Much Vitamin D for Neonates?

How Much Vitamin D for Neonates?

Factors affecting newborn bone mineral content:in uteroeffects on newborn bone mineralization

Association between calcium in cord blood and newborn size in Bangladesh

Contact Info

Product

Resources

About