How Much Vitamin D for Neonates?

Pittard, William B.; Geddes, Kitty M.; Hulsey, Thomas C.; Hollis, Bruce W.

doi:10.1001/archpedi.1991.02160100079027

Cited by 40 publications

(42 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The infant 25-hydroxyvitamin D concentrations indicated vitamin D sufficiency at each time assessed in all infants with no serum measurement less than 10 ng/mL except in cord blood ( Table 2). The vitamin D data are further described in a separate report (20). DISCUSSION Although the precise function of Gla in bone synthesis is not clear, certain characteristics of this protein are well described.…”

Section: Resultsmentioning

confidence: 97%

Osteocalcin, Skeletal Alkaline Phosphatase, and Bone Mineral Content in Very Low Birth Weight Infants: A Longitudinal Assessment

et al. 1992

View full text Add to dashboard Cite

ABSTRAm. Serum osteocalcin (Gla) and skeletal alkaline phosphatase (SAP) concentration both reflect osteoblast activity in the dynamic process of bone formation. To assess the relation in premature infants between change in bone mineral content (BMC) and both Gla and SAP serum concentration, we longitudinally measured BMC via photon absorptiometry and serum Gla and SAP concentration from birth to 16 wk in 20 very low birth weight infants. Serum total calcium, phosphorus, parathyroid hormone, and vitamin D metabolite concentrations were also monitored.All serum values were measured in the 20 mothers at delivery. Cord blood Gla concentrations were significantly ( p < 0.03) greater than maternal levels, and by 1 wk had significantly ( p < 0.001) increased from birth values. Total calcium, parathyroid hormone, phosphorus, and vitamin D concentrations remained in the normal range throughout the study. The increase in serum Gla concentrations, birth to 1 wk, were significantly correlated with the simultaneous increase in 1,25-dihydroxyvitamin D concentrations. The correlation between the change in BMC, however, over the first 4 mo of life and both Gla and SAP serum concentrations failed to reach statistical significance. Finally, a significant ( p < 0.003) negative correlation was measured between serum Gla and SAP concentrations at wk 4, and, although not significant, a consistently negative correlation was measured from 1-16 wk of age. These data demonstrate a 1,25-dihydroxyvitamin D associated rise in neonatal serum Gla concentration during the 1st week after delivery, no significant correlation between the change in neonatal BMC over the first 4 mo of life and serum Gla or SAP concentration, and a consistent negative correlation between serum Gla and SAP concentrations. These data do not indicate that either serum Gla or SAP concentration is a reliable predictor for the change in bone mineral content of very low birth weight infants over the first 16 wk of life. (Pediatr Res 31: 181-185, 1992) Abbreviations Gla, osteocalcin SAP, skeletal alkaline phosphatase TAP, total alkaline phosphatase BMC, bone mineral content VLBW, very low birth weight (

show abstract

Section: Resultsmentioning

confidence: 97%

Osteocalcin, Skeletal Alkaline Phosphatase, and Bone Mineral Content in Very Low Birth Weight Infants: A Longitudinal Assessment

et al. 1992

View full text Add to dashboard Cite

show abstract

“…The European Society of Paediatric Gastroenterology and Nutrition (ESPGAN) recommended a dose of 800-1,600 IU/day, while the American Academy of Pediatrics (AAP) and the Canadian Pediatric Society recommended 400 IU/day [64,65]. Several studies indicate that a daily vitamin D intake of up to 400 IU maintains normal skeletal development and vitamin D status, while higher dosages may have a potential risk for hypercalcemia and subsequent complications [66][67][68]. A randomized study showed that 200 up to 400 IU vitamin D per day and 960 IU/day intake (vitamin D content of used formula plus supplementation) have no different influence on bone mineral accretion in preterm infants [69].…”

Section: Vitamin D and Preterm Infantsmentioning

confidence: 99%

Consensus Development for the Supplementation of Vitamin D in Childhood and Adolescence

et al. 2002

View full text Add to dashboard Cite

“…In a study by Pittard et al [19] in preterm and term infants whose mother had normal 25-OH D levels, supplementation with 400-800 IU of Vit D were compared and it was concluded that daily dose of 400 IU was sufficient to achieve normal serum 25-OD D levels.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation - Is It Essential for Lactating Mothers and Breast - Fed Infants??

Varghese¹,

Palocaren²,

Ramachandran³

et al. 2015

jemds

View full text Add to dashboard Cite

Vit D deficiency is an upcoming health problem in both developed and developing countries. It is an essential nutrient required for bone metabolism and growth. Need for vitamin D and calcium is higher in embryonic period, infancy, early childhood, puberty, pregnancy, lactation and old age. Vit D supplementation is not included in the present antenatal care and Integrated Management of Neonatal and Childhood Illness (IMNCI) programmes in India. AIMThis study was done to evaluate the Vit D status of lactating mothers and their exclusively breast fed infants. The study also aims to find the correlation of Vit D with the blood biochemical markers like ALP, PTH, calcium, phosphorus and find the risk factors associated with hypovitaminosis D in infants. MATERIALS AND METHODSFifty two lactating mothers and their exclusively breastfed infants up to 4 months age were selected and their blood was analysed for Vit D, calcium, phosphorus, ALP and PTH. RESULTSAn 86% of mothers and 87% of infants showed hypovitaminosis D. There is significant positive correlation between maternal and infant Vit D levels. Vit D of infants showed significant inverse correlation with BMI of mothers and PTH of infants. CONCLUSIONVit D status of exclusively breast fed infants depend on maternal Vit D levels. Infant's bone mineral status is affected by hypovitaminosis D. Therefore, both mothers and infants should be supplemented with Vit D to prevent complications in future.

show abstract

How Much Vitamin D for Neonates?

Cited by 40 publications

References 10 publications

Osteocalcin, Skeletal Alkaline Phosphatase, and Bone Mineral Content in Very Low Birth Weight Infants: A Longitudinal Assessment

Osteocalcin, Skeletal Alkaline Phosphatase, and Bone Mineral Content in Very Low Birth Weight Infants: A Longitudinal Assessment

Consensus Development for the Supplementation of Vitamin D in Childhood and Adolescence

Vitamin D Supplementation - Is It Essential for Lactating Mothers and Breast - Fed Infants??

Contact Info

Product

Resources

About